Title:
PREPARATION METHOD FOR C15 PHOSPHINE SALT
Document Type and Number:
WIPO Patent Application WO/2022/241670
Kind Code:
A1
Abstract:
Disclosed is a preparation method for a C15 phosphine salt, comprising the following steps: reacting vinyl ionol with an acid to generate an intermediate; reacting the intermediate with organic phosphorus to obtain the C15 phosphine salt, wherein the mass of the intermediate in the reaction process is less than 1% on the basis of the mass of the vinyl ionol being 100%. By controlling the content of the intermediate in the system during the reaction process, the unit reaction rate is increased, the amount of byproducts is reduced, the impurity content is reduced, and the utilization rate of raw materials is increased. The preparation method has a simple process and a high production efficiency, a high unit yield of the target product, can obtain a high-purity C15 phosphine salt in a high-yield by means of desolvation without the need for complex post-treatment and purification processes, and the product has a low deterioration rate and a high quality throughout the storage process, can be directly used as a raw material for synthesizing vitamin A and derivatives thereof, and can meet the downstream requirements without the need for any pretreatment operations.
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Inventors:
LUO ZHAOHUI (CN)
LV YINGDONG (CN)
PAN XIAOYI (CN)
FENG XINGLEI (CN)
LIN LONG (CN)
LV YINGDONG (CN)
PAN XIAOYI (CN)
FENG XINGLEI (CN)
LIN LONG (CN)
Application Number:
PCT/CN2021/094551
Publication Date:
November 24, 2022
Filing Date:
May 19, 2021
Export Citation:
Assignee:
WANHUA CHEMICAL GROUP CO LTD (CN)
International Classes:
C07F9/54
Foreign References:
| CN1894265A | 2007-01-10 | |||
| CN108752251A | 2018-11-06 |
Other References:
KILDAHL-ANDERSEN GEIR, ANTHONSEN THORLEIF, LIAAEN-JENSEN SYNNØVE: "Longer polyenyl cations in relation to soliton theory", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 5, no. 17, 1 January 2007 (2007-01-01), pages 2803, XP093007667, ISSN: 1477-0520, DOI: 10.1039/b706212e
KHACHIK, F. ET AL.: "Synthesis of C45-β-carotene，a potentially useful internal standard for quantification of hydrocarbon carotenoids by high-performance liquid chromatography", INDUSTRIAL & ENGINEERING CHEMISTRY PRODUCT RESEARCH AND DEVELOPMENT, vol. 25, no. 4, 1 December 1986 (1986-12-01), XP093007668, ISSN: 0196-4321
KHACHIK, F. ET AL.: "Synthesis of C45-β-carotene，a potentially useful internal standard for quantification of hydrocarbon carotenoids by high-performance liquid chromatography", INDUSTRIAL & ENGINEERING CHEMISTRY PRODUCT RESEARCH AND DEVELOPMENT, vol. 25, no. 4, 1 December 1986 (1986-12-01), XP093007668, ISSN: 0196-4321
Attorney, Agent or Firm:
BEYOND ATTORNEYS AT LAW (CN)
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