Title:
PROCESS FOR PRODUCING CHROMONE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2003/080555
Kind Code:
A1
Abstract:
A process for producing a dicarboxylic acid compound represented by the formula (4): (4) (wherein R1 and R2 are the same or different and each represents lower alkyl; and the wavy line indicates that this compound is the (E) or (Z) isomer or a mixture of both), characterized by reacting a compound represented by the formula (2): (2) (wherein R1, R2, and the wavy line have the same meanings as the above; and one of X2 and X3 represents hydrogen and the other represents halogeno) with a nitrophenol represented by the formula (3): (3) in the presence of a base; a process for producing a nitrochromone compound represented by the formula (5): (5) (wherein R1 has the same meaning as the above), characterized by reacting the dicarboxylic acid compound or a carboxylic acid thereof with an acid; a process for producing an aminochromone compound which comprises reducing the nitrochromone compound; and a process for producing an amidochromone compound which comprises acylating the aminochromone compound.
Inventors:
HIBINO HIROAKI (JP)
OHTSUKA SUSUMU (JP)
MIYAMOTO YASUNOBU (JP)
YOSHIDA TOMOYASU (JP)
OKUMOTO ITSUO (JP)
OHTSUKA SUSUMU (JP)
MIYAMOTO YASUNOBU (JP)
YOSHIDA TOMOYASU (JP)
OKUMOTO ITSUO (JP)
Application Number:
PCT/JP2003/002182
Publication Date:
October 02, 2003
Filing Date:
February 27, 2003
Export Citation:
Assignee:
SUMITOMO CHEMICAL CO (JP)
ONO PHARMACEUTICAL CO (JP)
HIBINO HIROAKI (JP)
OHTSUKA SUSUMU (JP)
MIYAMOTO YASUNOBU (JP)
YOSHIDA TOMOYASU (JP)
OKUMOTO ITSUO (JP)
ONO PHARMACEUTICAL CO (JP)
HIBINO HIROAKI (JP)
OHTSUKA SUSUMU (JP)
MIYAMOTO YASUNOBU (JP)
YOSHIDA TOMOYASU (JP)
OKUMOTO ITSUO (JP)
International Classes:
C07C205/37; C07D311/24; (IPC1-7): C07C201/12; C07C67/307; C07C69/63; C07C205/37; C07D311/24
Foreign References:
| GB1292602A | 1972-10-11 | |||
| EP0309711A1 | 1989-04-05 | |||
| EP0485984A2 | 1992-05-20 | |||
| GB1585168A | 1981-02-25 | |||
| EP0634409A1 | 1995-01-18 | |||
| JPH0395144A | 1991-04-19 | |||
| JPH0395144A | 1991-04-19 | |||
| JPS5690017A | 1981-07-21 | |||
| JPS6150977A | 1986-03-13 | |||
| EP0634409A1 | 1995-01-18 |
Other References:
STOERMER MARTIN J. ET AL.: "A selective and versatile synthesis of substituted chromones via addition of phenols to dimethyl acetylenedicarboxylate", AUSTRALIAN JOURNAL OF CHEMISTRY, vol. 48, no. 3, 1995, pages 677 - 686, XP002969313
PROTIVA MOROSLAV ET AL.: "Potential cerebral stimulants: esters of 2-(dimethylamino)ethanol with some lipophilic carboxylic acids", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 55, no. 5, 1990, pages 1278 - 1289, XP002969314
See also references of EP 1479667A4
PROTIVA MOROSLAV ET AL.: "Potential cerebral stimulants: esters of 2-(dimethylamino)ethanol with some lipophilic carboxylic acids", COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, vol. 55, no. 5, 1990, pages 1278 - 1289, XP002969314
See also references of EP 1479667A4
Attorney, Agent or Firm:
Aoyama, Tamotsu (3-7 Shiromi 1-chom, Chuo-ku Osaka-shi Osaka, JP)
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