Title:
PROLACTIN INDUCED INCREASE IN NEUTRAL STEM CELL NUMBERS AND THERAPEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO2003024472
Kind Code:
A3
Abstract:
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using prolactin. The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from neurodegenerative diseases or conditions. In addition, since neural stem cells are a source for olfactory neurons, the present invention also provides methods of increasing olfactory neurons and enhancing olfactory functions.
Inventors:
WEISS SAMUEL (CA)
SHINGO TETSURO (JP)
SHINGO TETSURO (JP)
Application Number:
PCT/CA2002/001345
Publication Date:
September 18, 2003
Filing Date:
August 30, 2002
Export Citation:
Assignee:
STEM CELL THERAPEUTICS INC (CA)
WEISS SAMUEL (CA)
SHINGO TETSURO (JP)
WEISS SAMUEL (CA)
SHINGO TETSURO (JP)
International Classes:
A61K31/565; A61K35/30; A61K38/00; A61K38/22; A61K38/27; A61K38/30; A61P21/00; A61P25/00; A61P25/14; A61P25/16; A61P25/28; C12N5/0797; A61L27/00; A61K35/12; (IPC1-7): C12N5/06; C12N5/08; A61K38/22; A61K38/27; A61K38/30; A61K35/30; A61P25/00
Domestic Patent References:
| WO2000013650A2 | 2000-03-16 | |||
| WO1999021966A1 | 1999-05-06 | |||
| WO2000005260A1 | 2000-02-03 |
Other References:
GAGE FRED H: "Mammalian neural stem cells.", SCIENCE (WASHINGTON D C)., vol. 287, no. 5457, 25 February 2000 (2000-02-25), pages 1433 - 1438, XP002220467, ISSN: 0036-8075
PHELPS CAROL J ET AL: "Pituitary hormones as neurotrophic signals: Update on hypothalamic differentiation in genetic models of altered feedback.", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 222, no. 1, October 1999 (1999-10-01), pages 39 - 58, XP001109226, ISSN: 0037-9727
DICICCO-BLOOM E ET AL: "The PACAP ligand/receptor system regulates cerebral cortical neurogenesis.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. UNITED STATES 11 DEC 1998, vol. 865, 11 December 1998 (1998-12-11), pages 274 - 289, XP001080359, ISSN: 0077-8923
LEE MATTHEW ET AL: "Pituitary adenylyl cyclase-activating polypeptide stimulates DNA synthesis but delays maturation of oligodendrocyte progenitors.", JOURNAL OF NEUROSCIENCE, vol. 21, no. 11, 1 June 2001 (2001-06-01), pages 3849 - 3859, XP002245598, ISSN: 0270-6474
PHELPS CAROL J ET AL: "Pituitary hormones as neurotrophic signals: Update on hypothalamic differentiation in genetic models of altered feedback.", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 222, no. 1, October 1999 (1999-10-01), pages 39 - 58, XP001109226, ISSN: 0037-9727
DICICCO-BLOOM E ET AL: "The PACAP ligand/receptor system regulates cerebral cortical neurogenesis.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. UNITED STATES 11 DEC 1998, vol. 865, 11 December 1998 (1998-12-11), pages 274 - 289, XP001080359, ISSN: 0077-8923
LEE MATTHEW ET AL: "Pituitary adenylyl cyclase-activating polypeptide stimulates DNA synthesis but delays maturation of oligodendrocyte progenitors.", JOURNAL OF NEUROSCIENCE, vol. 21, no. 11, 1 June 2001 (2001-06-01), pages 3849 - 3859, XP002245598, ISSN: 0270-6474
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