Title:
PROTEIN DEGRADATION COMPOUND TARGETING MALT1
Document Type and Number:
WIPO Patent Application WO/2023/143249
Kind Code:
A1
Abstract:
Disclosed in the present invention are a compound that inhibits MALT1 and promotes the degradation of MALT1 by means of recruiting E3 ubiquitin ligase, and the use of the compound in the preparation of a drug for treating related diseases mediated by a MALT1 target. Specifically disclosed are a compound as represented by formula (Ⅰ') and a pharmaceutically acceptable salt thereof.
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Inventors:
QIN HUA (CN)
SUN DAQING (CN)
FU JIASHENG (CN)
XIN ZHENGYUAN (CN)
CHEN XU (CN)
SHI GUQIN (CN)
CHI BO (CN)
FENG HAO (CN)
SUN DAQING (CN)
FU JIASHENG (CN)
XIN ZHENGYUAN (CN)
CHEN XU (CN)
SHI GUQIN (CN)
CHI BO (CN)
FENG HAO (CN)
Application Number:
PCT/CN2023/072620
Publication Date:
August 03, 2023
Filing Date:
January 17, 2023
Export Citation:
Assignee:
SHANGHAI QILU PHARMACEUTICAL RES AND DEVELOPMENT CENTRE LTD (CN)
International Classes:
C07D487/04; A61K31/438; A61K31/4412; A61K31/4436; A61K31/4439; A61K31/444; A61K31/519; A61P35/00; C07D401/14; C07D417/14; C07D471/10; C07D487/10
Domestic Patent References:
| WO2018085247A1 | 2018-05-11 | |||
| WO2020264499A1 | 2020-12-30 | |||
| WO2022235698A1 | 2022-11-10 |
Foreign References:
| CN106170489A | 2016-11-30 | |||
| CN109641874A | 2019-04-16 | |||
| CN113412259A | 2021-09-17 | |||
| CN113710661A | 2021-11-26 |
Attorney, Agent or Firm:
PATENTSINO IP FIRM (CN)
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