REAGENTS THAT FACILITATE THE PURIFICATION OF COMPOUNDS SYNTHESIZED ON A SOLID SUPPORT

Title:

REAGENTS THAT FACILITATE THE PURIFICATION OF COMPOUNDS SYNTHESIZED ON A SOLID SUPPORT

Document Type and Number:

WIPO Patent Application WO2003017930

Kind Code:

A3

Abstract:

Disclosed is a novel capping-and-tagging ("cap-tag") strategy that aids in the purification of compounds assembled by multi-step synthetic methods. The incorporation of a unique cap-tag into undesired intermediates during a multi-step synthesis allows for the straightforward removal of these undesired compounds at the conclusion of the synthetic protocol by several methods based on affinity chromatography and scavenging resins. Importantly, this invention may be exploited in any automated synthetic protocol. In preferred embodiments, the cap-tag system is exploited for the purification of carbohydrates prepared via automated solid-phase methods.

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Inventors:

SEEBERGER PETER H
HEWITT MICHAEL C
PALMACCI EMMA R
PLANTE OBADIAH J

Application Number:

PCT/US2002/026069

Publication Date:

September 25, 2003

Filing Date:

August 15, 2002

Export Citation:

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Assignee:

MASSACHUSETTS INST TECHNOLOGY (US)

International Classes:

C07B61/00; C07B63/02; C07H21/00; C07H21/04; (IPC1-7): B01J8/04; C08B37/00

Foreign References:

US6538117B1

2003-03-25

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