Title:
RXR MODULATORS WITH IMPROVED PHARMACOLOGIC PROFILE
Document Type and Number:
WIPO Patent Application WO2001019770
Kind Code:
A3
Abstract:
The present invention provides a novel class of RXR modulator compounds that exhibit an improved pharmacologic profile relative to the profile of previously studied RXR modulators, including those that share common structural features with the presently claimed modulators. The present invention also provides synthetic methods for preparing these compounds as well as pharmaceutical compositions incorporating these novel compounds and methods for the therapeutic use of such compounds and pharmaceutical compositions.
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Inventors:
ARDECKY ROBERT J (US)
BOEHM MARCUS F (US)
FAULKNER AMY L (US)
HAMANN LAWRENCE G (US)
JONES TODD K (US)
MAPES CHRISTOPHER M (US)
MICHELLYS PIERRE-YVES (US)
TYHONAS JOHN S (US)
THOMPSON ANTHONY J (US)
CHEN JYUN-HUNG (US)
BOEHM MARCUS F (US)
FAULKNER AMY L (US)
HAMANN LAWRENCE G (US)
JONES TODD K (US)
MAPES CHRISTOPHER M (US)
MICHELLYS PIERRE-YVES (US)
TYHONAS JOHN S (US)
THOMPSON ANTHONY J (US)
CHEN JYUN-HUNG (US)
Application Number:
PCT/US2000/025476
Publication Date:
December 20, 2001
Filing Date:
September 14, 2000
Export Citation:
Assignee:
LIGAND PHARM INC (US)
ARDECKY ROBERT J (US)
BOEHM MARCUS F (US)
FAULKNER AMY L (US)
HAMANN LAWRENCE G (US)
JONES TODD K (US)
MAPES CHRISTOPHER M (US)
MICHELLYS PIERRE YVES (US)
TYHONAS JOHN S (US)
THOMPSON ANTHONY J (US)
CHEN JYUN HUNG (US)
ARDECKY ROBERT J (US)
BOEHM MARCUS F (US)
FAULKNER AMY L (US)
HAMANN LAWRENCE G (US)
JONES TODD K (US)
MAPES CHRISTOPHER M (US)
MICHELLYS PIERRE YVES (US)
TYHONAS JOHN S (US)
THOMPSON ANTHONY J (US)
CHEN JYUN HUNG (US)
International Classes:
C07D249/06; A61K31/192; A61K31/196; A61K31/197; A61K31/341; A61K31/381; A61K31/4192; A61K31/4418; A61P3/04; A61P3/06; A61P3/10; A61P5/48; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P17/16; A61P25/02; A61P25/16; A61P25/28; A61P35/00; A61P43/00; C07C59/64; C07C59/68; C07C59/72; C07C229/44; C07D213/55; C07D307/54; C07D333/24; (IPC1-7): C07C59/64; C07C59/72; C07D333/24; C07D307/54; C07D213/55; C07C37/055; C07C41/52; C07C45/29; C07C47/277; C07C67/343; C07C69/734; A61K31/203; A61P17/06; A61P9/00; A61P17/10; A61P5/14
Domestic Patent References:
| WO2000053562A1 | 2000-09-14 | |||
| WO1997012853A1 | 1997-04-10 | |||
| WO1996020913A1 | 1996-07-11 |
Foreign References:
| US5776699A | 1998-07-07 | |||
| US5910508A | 1999-06-08 | |||
| US5705167A | 1998-01-06 |
Other References:
CANAN KOCH S S ET AL: "IDENTIFICATION OF THE FIRST RETINOID X RECEPTOR HOMODIMER ANTAGONIST", JOURNAL OF MEDICINAL CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 39, no. 17, 16 August 1996 (1996-08-16), pages 3229 - 3234, XP000613612, ISSN: 0022-2623
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