Title:
SCREENING METHOD FOR THERAPEUTIC DRUG OR PROPHYLACTIC DRUG FOR TAUOPATHY AND DIAGNOSTIC METHOD FOR TAUOPATHY
Document Type and Number:
WIPO Patent Application WO/2020/090966
Kind Code:
A1
Abstract:
Provided is a screening method that is for a therapeutic drug or prophylactic drug for tauopathy and that comprises (1) a step for bringing a tau oligomer into contact with the NMDA glutamate receptor in the presence or absence of a candidate compound, and (2) a step for assessing the direct binding of the tau oligomer to the NMDA glutamate receptor. Also, provided is a testing method that is for tauopathy and that comprises (1) a step for bringing a sample isolated from a subject into contact with the NMDA glutamate receptor, and (2) a step for quantifying a tau oligomer directly binding to the NMDA glutamate receptor.
Inventors:
KAWAI AKIYOSHI (JP)
KIMURA TETSUYA (JP)
WU HUHEHASI (JP)
KIMURA TETSUYA (JP)
WU HUHEHASI (JP)
Application Number:
PCT/JP2019/042743
Publication Date:
May 07, 2020
Filing Date:
October 31, 2019
Export Citation:
Assignee:
NAT CT GERIATRICS & GERONTOLOGY (JP)
International Classes:
C12Q1/02; G01N33/15; G01N33/50; G01N33/53; C07K14/47
Domestic Patent References:
| WO2016076435A1 | 2016-05-19 |
Foreign References:
| JP2013503201A | 2013-01-31 | |||
| US20150017657A1 | 2015-01-15 | |||
| US20090004112A1 | 2009-01-01 |
Other References:
SUN, XUYING ET AL.: "Extrasynaptic NMDA receptor-induced tau overexpression mediates neuronal death through suppressing survival signaling ERK Phosphorylation", CELL DEATH AND DISEASE, vol. 7, 2016, pages 1 - 11, XP055704334
Attorney, Agent or Firm:
OKUYAMA, Shoichi et al. (JP)
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