Title:
SELECTIVE ANALGESIC AGENTS
Document Type and Number:
WIPO Patent Application WO2003063779
Kind Code:
A3
Abstract:
The invention provides a method for producing a selective analgesic effect outside the brain (e.g. via opioid receptors in the spinal cord) of a mammal, comprising administering to the mammal, an effective analgesic dose of a compound that binds to delta-kappa opioid receptors in the mammal.
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Inventors:
PORTOGHESE PHILIP S (US)
Application Number:
PCT/US2003/002257
Publication Date:
February 03, 2005
Filing Date:
January 27, 2003
Export Citation:
Assignee:
UNIV MINNESOTA (US)
PORTOGHESE PHILIP S (US)
PORTOGHESE PHILIP S (US)
International Classes:
A61K31/435; A61K31/485; A61K45/00; A61P23/00; C07D489/09; A61P25/04; C07D491/10; C07D491/20; C07D495/20; (IPC1-7): A61K31/435; C07D491/20; C07D489/08; C07D495/20
Domestic Patent References:
| WO1999038869A1 | 1999-08-05 | |||
| WO2002080919A1 | 2002-10-17 |
Foreign References:
| EP0614898A1 | 1994-09-14 |
Other References:
SHARMA, SHIV KUMAR ET AL: "Transformation of a .kappa.-Opioid Receptor Antagonist to a .kappa.-Agonist by Transfer of a Guanidinium Group from the 5'- to 6'-Position of Naltrindole", JOURNAL OF MEDICINAL CHEMISTRY , 44(13), 2073-2079 CODEN: JMCMAR; ISSN: 0022-2623, 2001, XP002307521
WESSENDORF, M. W. ET AL: "Coexistence of kappa- and delta-opioid receptors in rat spinal cord axons", NEUROSCIENCE LETTERS , 298(3), 151-154 CODEN: NELED5; ISSN: 0304-3940, 2001, XP002307522
WESSENDORF, M. W. ET AL: "Coexistence of kappa- and delta-opioid receptors in rat spinal cord axons", NEUROSCIENCE LETTERS , 298(3), 151-154 CODEN: NELED5; ISSN: 0304-3940, 2001, XP002307522
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