Title:
TETRAHYDROISOQUINOLINE DERIVATIVE AS PAN-KRAS INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/169481
Kind Code:
A1
Abstract:
The present invention provides a tetrahydroisoquinoline derivative as a pan-KRAS inhibitor. Specifically, the present invention provides a tetrahydroisoquinoline derivative having a structural formula as shown in general formula (I) and a pharmaceutically acceptable salt thereof which have pan-KRAS inhibitory activity. The present invention also provides a preparation method for the derivative, a pharmaceutical composition thereof, a salt-forming compound thereof, and a use thereof in treating different types of tumors as a pan-KRAS inhibitor.
Inventors:
WEI ROBERT GUOPING (CN)
LIN YIHUI (CN)
DING ZHANGGEN (CN)
GONG JOHN (CN)
LIN YIHUI (CN)
DING ZHANGGEN (CN)
GONG JOHN (CN)
Application Number:
PCT/CN2023/080353
Publication Date:
September 14, 2023
Filing Date:
March 08, 2023
Export Citation:
Assignee:
3D MEDICINES SHANGHAI CO LTD (CN)
International Classes:
C07D413/12; A61K31/4725; A61K31/538; A61P35/00; A61P35/02; C07D401/12; C07D405/12; C07D409/12; C07D417/12
Domestic Patent References:
| WO2021005165A1 | 2021-01-14 | |||
| WO2021216770A1 | 2021-10-28 |
Foreign References:
| CN114874201A | 2022-08-09 | |||
| CN112262137A | 2021-01-22 |
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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