Title:
THERAPEUTIC AGENT OF PERIPHERAL BLOOD FLOW DISORDER
Document Type and Number:
WIPO Patent Application WO/2020/111249
Kind Code:
A1
Abstract:
Provided is a cell preparation for treating a peripheral blood flow disorder, the cell preparation including pluripotent stem cells (Muse cells) which are SSEA-3 positive and derived from mesenchymal tissues of a living body or cultured mesenchymal cells. The peripheral blood flow disorder is preferably a peripheral arterial disease, and more preferably, chronic arterial obstruction of the limbs.
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Inventors:
MATOBA SATOAKI (JP)
DEZAWA MARI (JP)
DEZAWA MARI (JP)
Application Number:
PCT/JP2019/046847
Publication Date:
June 04, 2020
Filing Date:
November 29, 2019
Export Citation:
Assignee:
KYOTO PREFECTURAL PUBLIC UNIV CORP (JP)
LIFE SCIENCE INST INC (JP)
LIFE SCIENCE INST INC (JP)
International Classes:
A61P9/00; A61K35/545; A61P9/08; A61P9/10
Domestic Patent References:
| WO2011007900A1 | 2011-01-20 | |||
| WO2018021515A1 | 2018-02-01 | |||
| WO2011007900A1 | 2011-01-20 |
Foreign References:
| JP5185443B2 | 2013-04-17 |
Other References:
MATOBA, SATOAKI: "Therapeutic Angiogenesis for Peripheral Artery Disease", KYŌTO FURITSU IKA DAIGAKU ZASSHI - JOURNAL OF KYŌTO PREFECTURAL UNIVERSITY OF MEDICINE, KYOTO-FU IGAKU SHINKOKAI, KYOTO, JP, vol. 125, no. 11, 30 November 2015 (2015-11-30), JP, pages 759 - 767, XP009528338, ISSN: 0023-6012
HOU X ET AL., MOL BIOL REP, vol. 37, 2010, pages 1467 - 1475
LIU J.HAO H.XIA L. ET AL.: "Hypoxia pretreatment of bone marrow mesenchymal stem cells facilitates angiogenesis by improving the function of endothelial cells in diabetic rats with lower ischemia", PLOS ONE, vol. 10, no. 5, 2015
XIE N.LI Z.ADESANYA T. M. ET AL.: "Transplantation of placenta-derived mesenchymal stem cells enhances angiogenesis after ischemic limb injury in mice", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 20, no. 1, 2016, pages 29 - 37, XP055466357, DOI: 10.1111/jcmm.12489
CUNPING YINYUAN LIANGJIAN ZHANGGUANGPING RUANZIAN LIRONGQING PANGXINGHUA PAN: "Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews", STEM CELLS INTERNATIONAL, vol. 2016, no. 2016, pages 9
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
KONDO K ET AL., ARTERIOSCLER. THROMB. VASE. BIOL., vol. 29, 2009, pages 61 - 66
OGURA, F. ET AL., STEM CELLS DEV., 20 November 2013 (2013-11-20)
See also references of EP 3888751A4
HOU X ET AL., MOL BIOL REP, vol. 37, 2010, pages 1467 - 1475
LIU J.HAO H.XIA L. ET AL.: "Hypoxia pretreatment of bone marrow mesenchymal stem cells facilitates angiogenesis by improving the function of endothelial cells in diabetic rats with lower ischemia", PLOS ONE, vol. 10, no. 5, 2015
XIE N.LI Z.ADESANYA T. M. ET AL.: "Transplantation of placenta-derived mesenchymal stem cells enhances angiogenesis after ischemic limb injury in mice", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 20, no. 1, 2016, pages 29 - 37, XP055466357, DOI: 10.1111/jcmm.12489
CUNPING YINYUAN LIANGJIAN ZHANGGUANGPING RUANZIAN LIRONGQING PANGXINGHUA PAN: "Umbilical Cord-Derived Mesenchymal Stem Cells Relieve Hindlimb Ischemia through Enhancing Angiogenesis in Tree Shrews", STEM CELLS INTERNATIONAL, vol. 2016, no. 2016, pages 9
KURODA Y ET AL., PROC NATL ACAD SCI USA, vol. 107, 2010, pages 8639 - 8643
WAKAO S ET AL., PROC NATL ACAD SCI USA, vol. 108, 2011, pages 9875 - 9880
KURODA Y ET AL., NAT PROTC, vol. 8, 2013, pages 1391 - 1415
KONDO K ET AL., ARTERIOSCLER. THROMB. VASE. BIOL., vol. 29, 2009, pages 61 - 66
OGURA, F. ET AL., STEM CELLS DEV., 20 November 2013 (2013-11-20)
See also references of EP 3888751A4
Attorney, Agent or Firm:
IP FIRM SHUWA (JP)
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