Title:
TOOLS AND METHODS USING MIRNA 182, 96 AND/OR 183 FOR TREATING PATHOLOGIES
Document Type and Number:
WIPO Patent Application WO/2015/044890
Kind Code:
A3
Abstract:
The present inventions relates to isolated nucleic acid molecules comprising a nucleotide sequence coding for mi RNA-182 (uuuggcaaugguagaacucacacu or ugguucuagacuugccaacua), miRNA-96 (uuuggcacuagcacauuuuugcu or aaucaugugcagugccaauaug) and/or mi RNA-183 (uauggcacugguagaauucacu or gugaauuaccgaagggccauaa) for use in treating or ameliorating a ciliopathy and/or a photoreceptor dysfunction.
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Inventors:
BUSSKAMP VOLKER (US)
FILIPOWICZ WITOLD (CH)
KROL JACEK (CH)
ROSKA BOTOND (CH)
FILIPOWICZ WITOLD (CH)
KROL JACEK (CH)
ROSKA BOTOND (CH)
Application Number:
PCT/IB2014/064826
Publication Date:
June 11, 2015
Filing Date:
September 25, 2014
Export Citation:
Assignee:
FRIEDRICH MIESCHER INST FOR BIOMEDICAL RES (CH)
BUSSKAMP VOLKER (US)
FILIPOWICZ WITOLD (CH)
KROL JACEK (CH)
ROSKA BOTOND (CH)
BUSSKAMP VOLKER (US)
FILIPOWICZ WITOLD (CH)
KROL JACEK (CH)
ROSKA BOTOND (CH)
International Classes:
C12N15/113; A61K31/7088; A61P27/02
Domestic Patent References:
| WO2009137807A2 | 2009-11-12 | |||
| WO2012078558A2 | 2012-06-14 | |||
| WO2010027838A1 | 2010-03-11 |
Other References:
SEUNG-OK LEE ET AL: "MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease", JOURNAL OF CLINICAL INVESTIGATION, vol. 118, no. 11, 3 November 2008 (2008-11-03), pages 3714 - 3724, XP055091419, ISSN: 0021-9738, DOI: 10.1172/JCI34922
K. MCARTHUR ET AL: "MicroRNA-200b Regulates Vascular Endothelial Growth Factor-Mediated Alterations in Diabetic Retinopathy", DIABETES, vol. 60, no. 4, 28 February 2011 (2011-02-28), pages 1314 - 1323, XP055091443, ISSN: 0012-1797, DOI: 10.2337/db10-1557
HUDSON MATTHEW B ET AL: "MicroRNA-182 targets FoxO3 and attenuates glucocorticoidinduced atrophic signaling", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 27, 24 April 2013 (2013-04-24), XP008166113, ISSN: 0892-6638
S. LUMAYAG ET AL: "Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 6, 22 January 2013 (2013-01-22), pages E507 - E516, XP055090663, ISSN: 0027-8424, DOI: 10.1073/pnas.1212655110
PRIYANKA PANDEY ET AL: "Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease", BMC SYSTEMS BIOLOGY, BIOMED CENTRAL LTD, LO, vol. 5, no. 1, 25 April 2011 (2011-04-25), pages 56, XP021101459, ISSN: 1752-0509, DOI: 10.1186/1752-0509-5-56
LOSCHER C J ET AL: "A common microRNA signature in mouse models of retinal degeneration", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD, LONDON, vol. 87, no. 6, 13 September 2008 (2008-09-13), pages 529 - 534, XP025685673, ISSN: 0014-4835, [retrieved on 20080913], DOI: 10.1016/J.EXER.2008.08.016
Q. ZHU ET AL: "Sponge Transgenic Mouse Model Reveals Important Roles for the MicroRNA-183 (miR-183)/96/182 Cluster in Postmitotic Photoreceptors of the Retina", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 36, 15 July 2011 (2011-07-15), pages 31749 - 31760, XP055090669, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.259028
LOSCHER CAROL J ET AL: "Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa", GENOME BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 8, no. 11, 22 November 2007 (2007-11-22), pages R248, XP021041514, ISSN: 1465-6906
JACEK KROL ET AL: "Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs", CELL, vol. 141, no. 4, 13 May 2010 (2010-05-13), pages 618 - 631, XP055090887, ISSN: 0092-8674, DOI: 10.1016/j.cell.2010.03.039
K. MCARTHUR ET AL: "MicroRNA-200b Regulates Vascular Endothelial Growth Factor-Mediated Alterations in Diabetic Retinopathy", DIABETES, vol. 60, no. 4, 28 February 2011 (2011-02-28), pages 1314 - 1323, XP055091443, ISSN: 0012-1797, DOI: 10.2337/db10-1557
HUDSON MATTHEW B ET AL: "MicroRNA-182 targets FoxO3 and attenuates glucocorticoidinduced atrophic signaling", FASEB JOURNAL, FED. OF AMERICAN SOC. FOR EXPERIMENTAL BIOLOGY, US, vol. 27, 24 April 2013 (2013-04-24), XP008166113, ISSN: 0892-6638
S. LUMAYAG ET AL: "Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 110, no. 6, 22 January 2013 (2013-01-22), pages E507 - E516, XP055090663, ISSN: 0027-8424, DOI: 10.1073/pnas.1212655110
PRIYANKA PANDEY ET AL: "Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease", BMC SYSTEMS BIOLOGY, BIOMED CENTRAL LTD, LO, vol. 5, no. 1, 25 April 2011 (2011-04-25), pages 56, XP021101459, ISSN: 1752-0509, DOI: 10.1186/1752-0509-5-56
LOSCHER C J ET AL: "A common microRNA signature in mouse models of retinal degeneration", EXPERIMENTAL EYE RESEARCH, ACADEMIC PRESS LTD, LONDON, vol. 87, no. 6, 13 September 2008 (2008-09-13), pages 529 - 534, XP025685673, ISSN: 0014-4835, [retrieved on 20080913], DOI: 10.1016/J.EXER.2008.08.016
Q. ZHU ET AL: "Sponge Transgenic Mouse Model Reveals Important Roles for the MicroRNA-183 (miR-183)/96/182 Cluster in Postmitotic Photoreceptors of the Retina", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 36, 15 July 2011 (2011-07-15), pages 31749 - 31760, XP055090669, ISSN: 0021-9258, DOI: 10.1074/jbc.M111.259028
LOSCHER CAROL J ET AL: "Altered retinal microRNA expression profile in a mouse model of retinitis pigmentosa", GENOME BIOLOGY, BIOMED CENTRAL LTD., LONDON, GB, vol. 8, no. 11, 22 November 2007 (2007-11-22), pages R248, XP021041514, ISSN: 1465-6906
JACEK KROL ET AL: "Characterizing Light-Regulated Retinal MicroRNAs Reveals Rapid Turnover as a Common Property of Neuronal MicroRNAs", CELL, vol. 141, no. 4, 13 May 2010 (2010-05-13), pages 618 - 631, XP055090887, ISSN: 0092-8674, DOI: 10.1016/j.cell.2010.03.039
Attorney, Agent or Firm:
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH (Basel, CH)
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