Title:
TRICYCLIC COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/016549
Kind Code:
A1
Abstract:
A tricyclic compound having a PPARγ-agonistic activity which is represented by general formula (I) [wherein Z represents a single bond or the like; Y represents a hydrogen atom, an optionally substituted lower alkyl or the like; X represents a hydrogen atom or the like; A represents aryl or the like; B and C are the same or different and represent an aromatic carbon ring or the like; R4 to R9 are the same or different and represent hydrogen or the like; V represents a single bond or the like; and R10 and R11 are the same or different and represent hydrogen or the like], a pharmaceutically acceptable salt of the same and so on.
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Inventors:
YANAGISAWA ARATA
UEHARA KEIJI
MATSUBARA MASAHIRO
UENO KIMIHISA
SUZUKI MICHIHIKO
KUBOYAMA TAKESHI
YAMAMOTO KEISUKE
TAMURA TOMOHIRO
UEHARA KEIJI
MATSUBARA MASAHIRO
UENO KIMIHISA
SUZUKI MICHIHIKO
KUBOYAMA TAKESHI
YAMAMOTO KEISUKE
TAMURA TOMOHIRO
Application Number:
PCT/JP2009/063957
Publication Date:
February 11, 2010
Filing Date:
August 06, 2009
Export Citation:
Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
YANAGISAWA ARATA
UEHARA KEIJI
MATSUBARA MASAHIRO
UENO KIMIHISA
SUZUKI MICHIHIKO
KUBOYAMA TAKESHI
YAMAMOTO KEISUKE
TAMURA TOMOHIRO
YANAGISAWA ARATA
UEHARA KEIJI
MATSUBARA MASAHIRO
UENO KIMIHISA
SUZUKI MICHIHIKO
KUBOYAMA TAKESHI
YAMAMOTO KEISUKE
TAMURA TOMOHIRO
International Classes:
C07C255/44; A61K31/277; A61K31/41; A61K31/4178; A61K31/4184; A61K31/4188; A61K31/422; A61K31/4245; A61P3/04; A61P3/06; A61P3/10; A61P9/12; A61P35/00; A61P43/00; C07D235/08; C07D257/04; C07D403/10; C07D405/14; C07D409/14; C07D413/04; C07D413/10; C07D413/14; C07D471/04
Domestic Patent References:
| WO2008096829A1 | 2008-08-14 | |||
| WO2005105736A1 | 2005-11-10 | |||
| WO2004052847A2 | 2004-06-24 | |||
| WO2004082621A2 | 2004-09-30 | |||
| WO2008096829A1 | 2008-08-14 | |||
| WO1990015599A1 | 1990-12-27 | |||
| WO1990015599A1 | 1990-12-27 |
Foreign References:
| JPH06228065A | 1994-08-16 | |||
| JP2008508365A | 2008-03-21 | |||
| JPS61267580A | 1986-11-27 | |||
| JPH01131169A | 1989-05-24 | |||
| JPH06228065A | 1994-08-16 | |||
| JP2526005B2 | 1996-08-21 | |||
| US5332744A | 1994-07-26 | |||
| EP0400835A1 | 1990-12-05 | |||
| JPH0578328A | 1993-03-30 | |||
| EP0400835A1 | 1990-12-05 | |||
| EP0502314A1 | 1992-09-09 |
Other References:
See also references of EP 2327690A4
J. BIOL. CHEM., vol. 270, 1995, pages 12953
J. MED. CHEM., vol. 39, 1996, pages 665
ONCOGEN, vol. 25, 2006, pages 2304
EUR. J. CANCER, vol. 44, no. 12, 2008, pages 1734
MOLECULAR ENDOCRINOLOGY, vol. 17, no. 4, 2003, pages 662
T.W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
J. CHEM. SOC. PERKIN TRANS.1, 1992, pages 313
SYNTHETIC COMMUNICATIONS, vol. 27, 1997, pages 1621
SYNTHESIS, 1987, pages 411
LEHMANN ET AL., J BIOL CHEM., vol. 270, 1995, pages 12953
HELVETICA CHIMICA ACTA, vol. 26, 1966, pages 214
J. BIOL. CHEM., vol. 270, 1995, pages 12953
J. MED. CHEM., vol. 39, 1996, pages 665
ONCOGEN, vol. 25, 2006, pages 2304
EUR. J. CANCER, vol. 44, no. 12, 2008, pages 1734
MOLECULAR ENDOCRINOLOGY, vol. 17, no. 4, 2003, pages 662
T.W. GREENE: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS INC.
J. CHEM. SOC. PERKIN TRANS.1, 1992, pages 313
SYNTHETIC COMMUNICATIONS, vol. 27, 1997, pages 1621
SYNTHESIS, 1987, pages 411
LEHMANN ET AL., J BIOL CHEM., vol. 270, 1995, pages 12953
HELVETICA CHIMICA ACTA, vol. 26, 1966, pages 214
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