Title:
TRIPTERYGIUM WILFORDII DITERPENE EPOXIDE HAVING FUNCTION OF KILLING MYC POSITIVE CELL, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/143330
Kind Code:
A1
Abstract:
The present invention relates to the field of medicines. The present invention relates to a compound used as an anti-cancer and/or immune disease drug, and specifically relates to a tripterygium wilfordii diterpene epoxide. In particular, the present invention relates to a tripterygium wilfordii diterpene epoxide having the function of killing MYC positive tumor cells and/or MYC positive immune cells, a method for preparing these compounds, and a use of these compounds.
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Inventors:
XU RONGZHEN (CN)
WU SHUIGAO (CN)
GAN XIAOXIAN (CN)
WU SHUIGAO (CN)
GAN XIAOXIAN (CN)
Application Number:
PCT/CN2023/072990
Publication Date:
August 03, 2023
Filing Date:
January 18, 2023
Export Citation:
Assignee:
HANGZHOU WEBEN PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C07J73/00; A61K31/343; A61K31/365; A61P35/00; A61P37/00; C07D493/22
Domestic Patent References:
| WO2017070878A1 | 2017-05-04 | |||
| WO2021208787A1 | 2021-10-21 | |||
| WO2015085447A1 | 2015-06-18 |
Foreign References:
| CN1261602A | 2000-08-02 | |||
| CN101255186A | 2008-09-03 | |||
| GB1431336A | 1976-04-07 | |||
| US20040235943A1 | 2004-11-25 | |||
| US20020193419A1 | 2002-12-19 | |||
| CN1483731A | 2004-03-24 | |||
| CN104327152A | 2015-02-04 | |||
| CN108676055A | 2018-10-19 | |||
| CN1316997A | 2001-10-10 |
Other References:
SU MENG-XIANG, WEN-DI ZHOU, JUAN LAN, BIN DI, TAI-JUN HANG1: "Rapid and Sensitive Analysis of Multiple Bioactive Constituents in Tripterygium Glycosides Tablets Using Liquid Chromatography Coupled with Time-of-flight Mass Spectrometry", JOURNAL OF SEPARATION SCIENCE, vol. 38, no. 5, 26 December 2015 (2015-12-26), pages 804 - 812, XP093082080, DOI: 10.1002/jssc.201400946
NING LILI, JIANG XIAOMEI, YE MIN, GUO HONGZHU, BI KAISHUN, GUO DEAN: "Structural determination and complete NMR spectral assignments of a new diterpenoid obtained from triptonide by biotransformation", MAGNETIC RESONANCE IN CHEMISTRY, JOHN WILEY , CHICHESTER, GB, vol. 41, no. 8, 1 August 2003 (2003-08-01), GB , pages 633 - 635, XP093082081, ISSN: 0749-1581, DOI: 10.1002/mrc.1213
NING LILI, JIANG XIAOMEI, YE MIN, GUO HONGZHU, BI KAISHUN, GUO DEAN: "Structural determination and complete NMR spectral assignments of a new diterpenoid obtained from triptonide by biotransformation", MAGNETIC RESONANCE IN CHEMISTRY, JOHN WILEY , CHICHESTER, GB, vol. 41, no. 8, 1 August 2003 (2003-08-01), GB , pages 633 - 635, XP093082081, ISSN: 0749-1581, DOI: 10.1002/mrc.1213
Attorney, Agent or Firm:
KING & WOOD MALLESONS (CN)
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