UREA COMPOUND OR SALT THEREOF

WIPO Patent Application WO/2008/023720

A1

[PROBLEMS] To provide a compound which can be used for the treatment of a disease associated with fatty acid amide hydrolase (FAAH), particularly frequent urination, urinary incontinence and/or overactive bladder. [MEANS FOR SOLVING PROBLEMS] It is confirmed that an urea compound chemical-structurally characterized by having a piperidine or piperazine ring or a salt of the compound has a good FAAH-inhibiting activity. The urea compound or a pharmaceutically acceptable salt thereof can increase the effective bladder capacity and ameliorate the state of frequent urination, and is therefore useful as a therapeutic agent for frequent urination, urinary incontinence and/or overactive bladder.

WO/2019/159596	METHOD FOR PREPARING COUPLED BODY OF LEAVING GROUP-CONTAINING ORGANIC COMPOUND AND ORGANOSILICON COMPOUND
JPS6379873	PRODUCTION OF 6-HYDROXYINDOLES

ISHII TAKAHIRO (JP)
SUGANE TAKASHI (JP)
KAKEFUDA AKIO (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
SATO KENTARO (JP)
KURIWAKI IKUMI (JP)
KITADA CHIKA (JP)
SUZUKI JOTARO (JP)

PCT/JP2007/066236

February 28, 2008

August 22, 2007

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ASTELLAS PHARMA INC (JP)
ISHII TAKAHIRO (JP)
SUGANE TAKASHI (JP)
KAKEFUDA AKIO (JP)
TAKAHASHI TATSUHISA (JP)
KANAYAMA TAKATOSHI (JP)
SATO KENTARO (JP)
KURIWAKI IKUMI (JP)
KITADA CHIKA (JP)
SUZUKI JOTARO (JP)

C07D209/08; A61K31/445; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/501; A61K31/53; A61K31/5377; A61P13/02; A61P13/10; C07D211/44; C07D213/74; C07D235/30; C07D237/22; C07D249/14; C07D251/42; C07D285/135; C07D295/16; C07D401/12; C07D405/12; C07D413/12; C07D417/12; C07D471/04

WO2006074025A1	2006-07-13
WO2006088075A1	2006-08-24
WO2006054652A1	2006-05-26
WO2006074025A1	2006-07-13
WO2003065989A2	2003-08-14
WO2004033422A2	2004-04-22
WO2006088075A1	2006-08-24

JP2004277320A	2004-10-07
JP2001122784A	2001-05-08

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See also references of EP 2065369A4

MORITA, Hiroshi et al. (3-11 Nihonbashi-Honcho 2-chom, Chuo-ku Tokyo 11, JP)

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