Title:
USE OF PPAR AGONIST FOR IMPROVEMENT OF ENERGY METABOLISM
Document Type and Number:
WIPO Patent Application WO/2024/019509
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition for preventing or treating metabolic diseases comprising a novel pan-PPAR agonist compound or a salt thereof as an active ingredient. As a pan-PPAR agonist, the compound or the salt thereof can be useful in pharmaceutical compositions for preventing or treating metabolic diseases such as obesity, diabetes, fatty liver diseases, dyslipidemia, cardiovascular diseases, and/or metabolic syndrome, and in food or feed compositions for improving metabolic health.
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Inventors:
KIM KYONG TAI (KR)
OH EUNJI (KR)
KANG JEONGHWA (KR)
CHO SUNGJI (KR)
JUNG HOE YUNE (KR)
LEE HEON JONG (KR)
OH EUNJI (KR)
KANG JEONGHWA (KR)
CHO SUNGJI (KR)
JUNG HOE YUNE (KR)
LEE HEON JONG (KR)
Application Number:
PCT/KR2023/010378
Publication Date:
January 25, 2024
Filing Date:
July 19, 2023
Export Citation:
Assignee:
NOVMETAPHARMA CO LTD (KR)
POSTECH RES & BUSINESS DEV FOUND (KR)
POSTECH RES & BUSINESS DEV FOUND (KR)
International Classes:
A61K31/405; A23K20/132; A23L33/10; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P9/00
Domestic Patent References:
| WO2006007864A1 | 2006-01-26 |
Other References:
DATABASE Registry 27 November 2007 (2007-11-27), ANONYMOUS : "L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-, 4-(4-methoxyphenyl)-8-methyl-2-oxo-2H-1-benzopyran-7-yl ester (CA INDEX NAME)", XP093131938, retrieved from STNext Database accession no. 956044-42-1
YANG YING; TIAN JIN-YING; YE FEI; XIAO ZHIYAN: "Identification of natural products as selective PTP1B inhibitors via virtual screening", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY., US, vol. 98, 5 March 2020 (2020-03-05), US , XP086138271, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2020.103706
YE WANG; DI WU; DAHAI YU; ZHIYONG WANG; LI TIAN; YANYAN WANG; WEIWEI HAN; XUEXUN FANG: "Computational study on new natural polycyclic compounds of H1N1 influenza virus neuraminidase", JOURNAL OF MOLECULAR MODELING, SPRINGER, DE, vol. 18, no. 8, 27 January 2012 (2012-01-27), DE , pages 3445 - 3453, XP035091272, ISSN: 0948-5023, DOI: 10.1007/s00894-011-1349-0
OH EUNJI, KANG JEONG-HWA, JO KYUNG WON, SHIN WON-SIK, JEONG YOUNG-HUN, KANG BYUNGHEE, RHO TAE-YOUNG, JEON SO YEON, LEE JIHOON, SON: "Synthetic PPAR Agonist DTMB Alleviates Alzheimer's Disease Pathology by Inhibition of Chronic Microglial Inflammation in 5xFAD Mice", NEUROTHERAPEUTICS : THE JOURNAL OF THE AMERICAN SOCIETY FOR EXPERIMENTAL NEUROTHERAPEUTICS, vol. 19, no. 5, 1 September 2022 (2022-09-01), pages 1546 - 1565, XP093131934, ISSN: 1878-7479, DOI: 10.1007/s13311-022-01275-y
YANG YING; TIAN JIN-YING; YE FEI; XIAO ZHIYAN: "Identification of natural products as selective PTP1B inhibitors via virtual screening", BIOORGANIC CHEMISTRY, ACADEMIC PRESS INC., NEW YORK, NY., US, vol. 98, 5 March 2020 (2020-03-05), US , XP086138271, ISSN: 0045-2068, DOI: 10.1016/j.bioorg.2020.103706
YE WANG; DI WU; DAHAI YU; ZHIYONG WANG; LI TIAN; YANYAN WANG; WEIWEI HAN; XUEXUN FANG: "Computational study on new natural polycyclic compounds of H1N1 influenza virus neuraminidase", JOURNAL OF MOLECULAR MODELING, SPRINGER, DE, vol. 18, no. 8, 27 January 2012 (2012-01-27), DE , pages 3445 - 3453, XP035091272, ISSN: 0948-5023, DOI: 10.1007/s00894-011-1349-0
OH EUNJI, KANG JEONG-HWA, JO KYUNG WON, SHIN WON-SIK, JEONG YOUNG-HUN, KANG BYUNGHEE, RHO TAE-YOUNG, JEON SO YEON, LEE JIHOON, SON: "Synthetic PPAR Agonist DTMB Alleviates Alzheimer's Disease Pathology by Inhibition of Chronic Microglial Inflammation in 5xFAD Mice", NEUROTHERAPEUTICS : THE JOURNAL OF THE AMERICAN SOCIETY FOR EXPERIMENTAL NEUROTHERAPEUTICS, vol. 19, no. 5, 1 September 2022 (2022-09-01), pages 1546 - 1565, XP093131934, ISSN: 1878-7479, DOI: 10.1007/s13311-022-01275-y
Attorney, Agent or Firm:
BAEK, Seoil (KR)
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