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JP2016041714A |
To provide methods for the treatment of sickle cell disease, acute chest syndrome, peripheral arterial disease, myocardial infarction, cerebral apoplexy, peripheral vascular disease, macular degeneration, multiple organ failure, ischemia...
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JP2016039879A |
To provide a new use for polyamide 4 in a living body.The present invention provides a medical material embedded in a living body, comprising a homopolymer or copolymer of polyamide 4.SELECTED DRAWING: None
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JP5885505B2 |
The present invention provides for compositions, methods and devices for rapidly converting silk fibroin solution into a silk fibroin gel using direct application of voltage, in a process called electrogelation. The silk fibroin gel may ...
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JP5871449B2 |
A method is disclosed for using tenecteplase to restore function in dysfunctional hemodialysis catheters, which have a blood flow rate of less than 300 mL/minute. Kits are also provided with instructions to direct the user to administer ...
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JP2016505722A |
The present invention relates to hydrophobic derivatives of hyaluronan, especially C on the hydroxyl group of hyaluronic acid.11-C18-Biodegradable fibers based on acylated hyaluronan derivatives, and their use. Furthermore, the present i...
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JPWO2013176084A1 |
To provide a novel silane coupling agent. The following equation (1): [Chemical 1](In the formula, R1, R2And R3Represent each independently an alkyl group having 1 to 5 carbon atoms, and R4And R5Each independently represents an alkyl gro...
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JP5835751B2 |
A medical absorbable hemostatic and wound healing promoting material for bone wounds and a preparation method thereof. The absorbable hemostatic material for bone wounds is formed of 40-95% of a base material and 5-60% of an adjuvant, ba...
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JP2015213755A |
To provide immobilized non-fouling coatings, particularly, coatings that resist the adhesion of biological material and are attached to a substrate surface through a graft-from method.A composition comprises a substrate, and optionally c...
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JP2015212254A |
To provide a composition, a method and a device for rapidly converting silk fibroin solution into silk fibroin gel.Silk fibroin gel produced by applying electric field to solubilized silk fibroin solution is reversibly converted into a l...
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JP5814242B2 |
The present invention relates to immobilized biologically active entities that retain a significant biological activity following manipulation. The invention also comprises a medical substrate comprising a heparin entity bound onto a sub...
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JP5808809B2 |
A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.
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JP2015193646A |
To provide novel polymer conjugates of polypeptide variants of the HMGB1 high affinity binding domain Box-A (HMGB1 Box-A) or of a biologically active fragment of HMGB1 Box-A; novel polymer conjugates of polypeptide variants of the HMGB1 ...
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JP5805617B2 |
The present invention relates to inhibiting or preventing infection and protecting against patency complications after a blood catheter has been inserted in a patient comprising administering to the device a pharmaceutically effective am...
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JP2015181794A |
To provide a dialyzer that is molded from a molding material suppressing deterioration of physical properties, such as devitrification (whitening) and mechanical properties, due to hydrolysis that may occur when sterilized by a steam ste...
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JP5796911B2 |
The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easie...
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JP2015180265A |
To provide a safe catheter lock solution capable of exterminating quickly bacteria or a biofilm formed beforehand.A catheter lock solution contains a hydrochloric acid solution having a 0.3-1.0 mol concentration. Further, the hydrochlori...
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JP5792295B2 |
The present invention generally relates to vulcanization compositions used to vulcanize elastomeric articles, where the vulcanization compositions have reduced allergenic potential as compared to elastomeric articles formed using vulcani...
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JP5784053B2 |
Disclosed herein are methods of treating an article surface. The method comprises removing a metal oxide surface from the metal substrate to expose a metal surface; and delivering particles comprising a dopant from at least one fluid jet...
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JP2015527117A |
Implantable biocompatible biosensors are described herein. This biosensor consists of a chip layer containing multiple pores made vertically through the chip layer, a power source, one or more sensors on the chip layer and connected to t...
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JP5775454B2 |
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation...
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JP2015524694A |
The present invention is a medical device detectable by magnetic resonance imaging (MRI), wherein the medical device comprises an envelope polymer that is at least partially removed at the tip of the medical device. A coating is provided...
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JP5758072B2 |
A method of making an intraluminal medical device (10)(1206) having a plurality of openings (30) therein involves applying a mask (1202) to interior surfaces (1204) of a scaffold which has openings formed in it. A coating (1208) which in...
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JP2015131118A |
To provide an extracorporeal blood circuit which reduces thrombus formation based on the treatment requiring pumping of blood from and to a patient, and a polymer component of the extracorporeal blood circuit having a surface capable of ...
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JP5743173B2 |
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JP2015097550A |
To provide a blood compatible material having excellent anticoagulation activity, capable of forming a stable coating layer on a substrate with a simple and mild coating process.The blood compatible material includes a copolymer composed...
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JP5718913B2 |
The present invention includes a catheter locking solution having both antimicrobial and anticoagulant properties including a local anesthetic and a viscosifying agent. The local anesthetic of the present invention may be an amino amide;...
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JP5702857B1 |
The present invention relates to an extracorporeal blood circulation circuit and its components (eg, hollow fiber membranes, contained bundles, and blood tubes), the components of which are 0.005% to 10% (w / w) surface-modified polymers...
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JP2015066450A |
To provide a blood compatible article and a method for producing the article.This method includes: providing a substrate; and forming a rough surface on the substrate. The rough surface includes a plurality of three-dimensionally curved ...
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JP2015509785A |
The present invention is an improved biocompatible surface for a variety of medical purposes. This biocompatible surface employs a unique dense microstructure that exhibits an enhanced cellular response within the body, especially when p...
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JP5693475B2 |
A stent scaffold combined with amniotic tissue provides for a biocompatible stent that has improved biocompatibility and hemocompatibility. The amnion tissue can be variously modified or unmodified form of amnion tissue such as non-cryo ...
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JPWO2013051479A1 |
To provide a composition for forming a coating film having an effect of suppressing adhesion of biological substances such as proteins and cells such as platelets. The following formula (1): [Chemical formula 1] [In the formula, R1 repre...
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JPWO2013031459A1 |
Provided is a medical device whose surface exhibits lubricity and / or antithrombotic property when wet. The medical device of the present invention includes a base material layer and a hydrophilic layer supported on at least a part of t...
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JPWO2013027579A1 |
To provide a medical tube mainly made of a thermoplastic resin and having a blood contact surface heparinized to reduce quality defects due to whitening and oil defects. The present invention is a medical tube obtained by melt-extruding ...
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JP5684967B2 |
Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol,...
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JP5674378B2 |
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JP5676190B2 |
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JPWO2012176861A1 |
In the present invention, a compound capable of inhibiting both blood coagulation reactions at the stage of primary hemostasis involving platelets and the stage of coagulation thrombus formation involving blood coagulation factors is pre...
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JPWO2012176862A1 |
The present invention can inhibit both blood coagulation reactions at the stage of primary hemostasis involving platelets and the stage of coagulation thrombus formation involving blood coagulation factors, and retains anti-blood coagula...
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JPWO2012176841A1 |
The present invention reliably captures free thrombi and increases their usable time by inhibiting the blood coagulation reaction at the stage of primary hemostasis involving platelets and the stage of coagulation thrombus formation invo...
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JP5673756B2 |
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JP5660452B2 |
Previously reported composite materials comprising a hydrophilic high-molecular-weight matrix and a low-molecular-weight organic compound involve a problem in that: it is difficult to compound a high load of the low-molecular-weight orga...
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JP5655276B2 |
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JP5656241B2 |
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JP2015008845A |
To provide a balloon coating method capable of homogeneously forming, at a desired thickness, a coating layer and of coating while pharmaceutical morphological types, etc. are being freely adjusted depending on balloon sites.The provided...
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JP2015007260A |
To provide a composition for decreasing stent thrombosis and restenosis, and to provide an implantable device using the same.Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. ...
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JP5645085B2 |
The present invention relates to a method for preparing a radiolabeled macromolecule, the method comprising contacting a macromolecule with a carbon encapsulated nanoparticle composite having a radioactive particulate core in an aqueous ...
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JP2014533121A |
The device includes a surgical instrument having a proximal end and a distal end. The proximal end can include a handle. The distal end can include a cutter and stapler. The device can further include staples used with the stapler. The s...
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JP2014532654A |
Describe drugs, methods, and devices that affect neural function. One embodiment of the agent comprises a cardiac glycoside, an ACE inhibitor and an NSAID. The drug can be locally delivered site-specifically to the target nerve or part o...
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JP5636451B2 |
A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer...
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JP5636450B2 |
A stent includes a stent body of a cylindrical configuration having outer and inner surfaces, a first coated layer coating at least the outer surface, and a second coated layer coating substantially completely over the first coated layer...
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