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JP6163032B2 |
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JP6158917B2 |
A medical device includes an implantable structure and a coating layer including a water-insoluble therapeutic agent and one or more additives selected from heparin, heparan sulfate, dextran and dextran sulfate, and physiologically-accep...
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JP6150267B2 |
Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particu...
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JP6151680B2 |
The present invention relates to immobilized biologically active entities having heparin cofactor II binding activity.
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JP6150071B2 |
There is provided a novel organic silicon compound that can be used for a silane coupling agent. An organic silicon compound of Formula (1): (where A− is Formula (2) or Formula (3): E is Formula (4) or Formula (5): R1 and R2 are each i...
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JP6148565B2 |
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JP6147759B2 |
Novel, lubricious coatings for medical devices are disclosed. The coatings provide improved lubricity and durability, and are readily applied in coating processes. The present invention is also directed to a novel platinum catalyst for u...
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JP2017514642A |
The present invention relates to novel compositions for sclerotherapy. In particular, the present invention relates to catheters for the use of photoactivated biocompatible adhesives and the application of said adhesives. The catheter of...
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JP2017094179A |
To provide a biodegradable inside artificial organ and a production method thereof.Provided is a biodegradable embedding type appliance such as a stent including a biodegradable polymer, in which the polymer material is subjected to proc...
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JP2017512477A |
The present invention uses methods of differentiation, isolation, proliferation and storage of E. coli small colony variants (SCVs), preferably E. coli 83972 or E. coli HU2117, or modified or variant forms thereof, as well as produced SC...
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JP6132106B2 |
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JP2017082174A |
To provide a novel biocompatible polymer.There is provided a polymer having a structure represented by the following formula 1 in a side chain part: -L-(CH-O)-R(Formula 1), where L is a linker connecting a side chain to a polymer main ch...
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JP6122052B2 |
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an entity capable of interacting with mammalian blood to prevent coagulation...
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JP6118831B2 |
A surface treating agent is comprising a copolymer including: a monomer (A) having a hydrophilic functional group of formula (1) or (2) below, a monomer (B) having a basic functional group and a monomer (C) having a reactive functional g...
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JPWO2015146897A1 |
Provided and used a polymer compound that can be expected to suppress the activation of the coagulation system, complement system, or platelet system when it comes into contact with in vivo tissues and / or blood by being able to contain...
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JP6104968B2 |
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JP2017507675A |
The present invention relates to a crosslinked PEG polymer coating that is hydrophilic, slippery and resistant to adsorption of biological materials including proteins and cells. This coating is based on formula R (OCH)2CH2)nIt is produc...
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JP6100427B2 |
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JPWO2015080176A1 |
In the present invention, an antithrombotic compound other than heparin or a derivative of heparin is fixed to a base material to prevent elution of the compound having antithrombotic property from the base material, and an antithromboti...
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JP6092211B2 |
A medical fastener has a first, pre-deployment shape for loading into a surgical instrument, and a second, post-deployment shape for connecting tissue together, and includes a crown and a pair of legs, each leg substantially transversely...
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JP6083071B2 |
A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, ...
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JP6080356B2 |
A surface treating agent is comprising a copolymer including: a monomer (A) having a hydrophilic functional group of formula (1) or (2) below, a monomer (B) having a basic functional group and a monomer (C) having a reactive functional g...
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JP6081358B2 |
This invention relates to methods and compositions for preparation of silk-PEGs based biomaterials through crosslinking by chemically reacting active polyethylene glycols (PEGs) possessing different chemical groups (e.g., thiols and male...
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JP2016220717A |
To provide an anti-thrombotic material capable of sufficiently exhibiting the anti-thrombotic properties of both an anti-thrombotic compound and a betaine compound while suppressing the elution of the compounds, in an anti-thrombotic com...
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JP2016220716A |
To provide a metallic material in which an anti-thrombotic compound other than heparin or a heparin derivative is fixed to the surface of the metallic material, the elution of the compound having anti-thrombotic properties from the metal...
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JP6054751B2 |
Expandable medical device comprising: elongated struts (18) joined together to form a cylindrical device (12) which is expandable from a cylinder having a first diameter to a cylinder with a second diameter, struts having width and thick...
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JP6042342B2 |
A stent or other implantable medical device for the local delivery of a selective adenosine receptor agonist may be utilized to reduce myocardial injury following an acute myocardial infarction. As soon as possible following an acute myo...
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JP6046331B2 |
The present invention relates to polymers modified to increase their resorbability. In particular, the polymers of the invention have phenyl ester side chains which are good leaving groups and which thereby increase the resorption rate o...
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JP6040451B2 |
Disclosed are self-assembling block copolymers including diblock copolymers of the formula (I): wherein R 1 -R 4 , n, and m are as described herein, which find use in preparing self-assembled structures and porous membranes. Embodiments ...
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JP2016198426A |
To provide a medical supply having not only an anti-thrombotic property but also an anti-inflammatory property.There is provided a medical supply coated with an A-B-A type block copolymer obtained, for example, by performing a polymeriza...
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JP6033861B2 |
A distal access aspiration guide catheter (100) having a proximal, medial, and distal possessing high flexibility, high resistance to kinking and a large lumen to wall thickness ratio.
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JP6019524B2 |
To provide a biocompatible material excellent in antithrombogenic property, a medical instrument and a method for using a biocompatible material.The biocompatible material contains a mixture of a polymer which maintains a glassy mixed ph...
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JP6014164B2 |
Catheters and a method of preparation thereof, the catheter comprising a catheter body, a juncture hub, extension lines and connectors, the catheter body having a proximal end, a distal end, an exterior surface, a tip region having a len...
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JP6003641B2 |
The purpose of the invention of the present application is to provide a medical material and a blood purification apparatus each having high anti-thrombotic properties and high safety. The apparatus is produced by incorporating therein a...
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JP5990531B2 |
The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pl...
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JP5982688B2 |
The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
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JP5969484B2 |
Provided is an antithrombotic material that has an excellent anticoagulant activity and can form a stable coating layer on a base material through a simple and mild coating process. Provided is an antithrombotic material of that includes...
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JP2016523635A |
Medical devices intended for insertion into the body include a non-biodegradable substrate having a tissue contact surface, the tissue contact surface being at least partially covered with type VI collagen microfibrils. We have found tha...
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JP5960612B2 |
There is described inter alia a medical device having a surface which comprises a coating layer, said coating layer being a biocompatible composition comprising an anti-coagulant entity capable of interacting with mammalian blood to prev...
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JP5954669B2 |
Radiopaque polymer compositions and methods for making the compositions are provided. These radiopaque polymer compositions include shape memory polymer compositions comprising a crosslinked polymer network, the network comprising a firs...
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JP2016127922A |
To provide a composition for delivery of a medicine selected from antibiotic, antibacterial agent, antiviral agent, antimicrobial agent, antiinflammatory drug, hemostatic agent, antithrombotic drug or antifungal agent to open fracture, c...
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JP5937092B2 |
A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include...
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JP5937668B2 |
A catheter containing a locking solution which comprises at least one poloxamer, at least one alcohol and at least one biocidal agent that is not an alcohol.
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JP5929471B2 |
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JP5925866B2 |
The present invention relates to polymers modified to increase their resorbability. In particular, the polymers of the invention have phenyl ester side chains which are good leaving groups and which thereby increase the resorption rate o...
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JP2016514171A |
[Subject] [Means for Solution] Polymer film, A covalent bond to a polymer matrix; distribution; within a polymer matrix, or its bothA polymer matrix which has at least one of a separated S-nitroso Thiol addition which is connected with a...
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JP2016063846A |
To provide a medical coating material having excellent hydrophilicity and a medical device coated with the material.A medical coating material contains a copolymer with a segment A having a structural unit originating from vinylimidazole...
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JP2016052525A |
To provide an anti-thrombus formable blood tube, and a blood dialysis filter using the same.Provided is a blood tube including a polyvinyl chloride base polymer mixed with a surface-modified polymer represented by the following equation,...
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JP2016052578A |
To provide a biodegradable inside artificial organ and a production method thereof.Provided is a biodegradable embedding type appliance such as a stent including a biodegradable polymer, in which the polymer material is subjected to proc...
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JP5902827B2 |
A hemostatic device, method of making, and method of using for internal and external applications to wounds in the body of a patient to induce hemostasis at an anatomical site.
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