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JP2022157235A |
To provide a composition containing a novel polymer that shows biocompatibility by having a polyoxyethylene structure in part of it, the polymer composition particularly useful as a coating agent and capable of giving biocompatibility to...
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JP2022541090A |
In various embodiments, the present invention relates to drug-loaded amino acid-based poly(ester urea) films that produce localized drug delivery for implanted devices. In some embodiments, the present invention relates to antibiotic-loa...
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JP7129071B2 |
The present invention provides a composition which is used to form a cured film that is disposed on a medical device and a medical device with a cured film, which are capable of suppressing both the adhesion of platelets and the adhesion...
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JP7128632B2 |
To provide a coating agent for medical supply capable of forming a coating film excellent in biocompatibility, especially antithrombotic property, a curable coating agent for medical supply, a polymer for medical supply, a coating method...
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JP7123346B2 |
Provided is a novel biocompatible material having improved biocompatibility. A biocompatible material comprising a fluoropolymer, said biocompatible material being characterized in that the fluoropolymer is a copolymer of a fluoroolefin ...
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JP2022535966A |
Provided herein is a method of grafting a polymer coating onto a first side of a wall of a device. The method includes applying an initiator substantially only to the second side of the wall, applying a coating composition to the first s...
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JP2022115980A |
To provide a copolymer that can be utilized as an ion complex material excellent in a function of inhibiting adhesion of a biological substance.A copolymer is obtainable from a monomer mixture containing compounds represented by the form...
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JP2022092454A |
To provide a blood compatibility medical titanium material capable of suppressing formation of clot on a surface, even in the case of contact with blood; and to provide a production method of the blood compatibility medical titanium mate...
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JP7087552B2 |
To provide a coating composition which is excellent in adhesion to various substrates and in wet rubbing resistance and exhibits good biocompatibility.A coating composition for forming a coating containing a betaine structure-containing ...
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JP2022528428A |
The present disclosure comprises a covalently bonded heparin coating on a substrate, wherein the covalently bonded heparin coating comprises (a) an isocyanate-containing material on the substrate or a covalently bonded isocyanate-contain...
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JP7080450B2 |
To provide a medical metallic material superior in antithrombogenicity and for being detained in vivo, and provide its manufacturing method and a medical instrument using the same.A medical metal material of the present invention compris...
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JP2022527348A |
A two-component, two-component composition, generally for the therapeutic treatment of skin lesions, as well as wounds, burns, bed pain and ulcers, the first component being in the form of an aqueous gel, with a cross-linking agent. The ...
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JP2022075995A |
To provide thermoplastic polyurethane compositions.The disclosed technology provides thermoplastic polyurethane compositions having antimicrobial properties while still maintaining good physical properties and good non-fouling properties...
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JP2022525305A |
Zwitterionic carboxybetaine copolymers and their use in coatings to impart non-adhesiveness and functionality to surfaces, especially surfaces of medical devices that come into contact with blood.
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JP2022525192A |
The present invention relates to medical devices applied to the human or animal body. When the medical device is applied to the human or animal body, the medical device includes a contact surface that comes into contact with the human or...
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JP2022524195A |
The present application provides a one-way pull-up implant thread (1) and a pull-up device, wherein the one-way pull-up implant thread (1) is a tow thread (11) and at least one cam fitted to the tow thread (11). A body (12) is included, ...
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JP7061426B2 |
Provided are a copolymer having biocompatibility sufficient for use in medical material applications, and a method of forming a crosslinked body, the method including imparting biocompatibility to a substrate surface through the use of t...
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JP2022523712A |
Pharmaceutical compositions comprising Factor XIa or a compound that inhibits kallikrein, and methods of use thereof, are provided herein. In some embodiments, the pharmaceutical composition comprises a compound of formula (IA), a cyclod...
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JP2022522271A |
A medical implant component containing a composite biotextile, wherein the biotextile contains at least one strand having a titer of i) 2 to 250 dtex, a tensile strength of at least 10 cN / dtex, and a high molar weight elastomer fiber. ...
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JP7043700B2 |
The present disclosure relates to anti-fouling and/or anti-thrombotic medical devices, methods for reducing fouling and/or thrombosis associated with medical devices, and methods for coating substrates to reduce fouling and/or thrombosis...
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JP7043936B2 |
To provide an antithrombogenic material that can reduce the amount of adsorption of vWF, a coagulation system protein, to the base material surface while letting it have an anticoagulant activity.The present invention provides an antithr...
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JP7043498B2 |
A silicone coating process that improves the durability of silicone coatings on the surfaces of surgical needles and other medical devices. The silicone coated surgical needles or medical devices produced by this process have both superi...
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JP7031307B2 |
The purpose of the present invention is to provide: a copolymer that is capable of being immobilized on a base material while maintaining a high antithrombotic property persistently without having to introduce heparin or an anticoagulant...
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JP2022034088A |
To provide a medical implement having sufficient mechanical characteristics, and being excellent in non-absorption with respect to a biological substance.There is provided a medical implement comprising: a substrate; and a film formed on...
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JP2022033253A |
To provide thermoplastic polyurethane compositions for solid freeform fabrication.The invention relates to compositions and methods for solid freeform fabrication of medical devices, components and applications, where the compositions in...
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JP2022515210A |
INDUSTRIAL APPLICABILITY The present invention is a product in the form of a pad or a film for treating a bleeding wound, wherein the product contains at least one fine particle crystalline inorganic polyphosphate atomized into an organi...
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JP7017726B2 |
Provided is a use for a peptide in surface-treating a medical device or medical material to be used in contact with blood, with which it is possible to obtain a medical device or medical material that can achieve highly efficient vascula...
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JP7005535B2 |
Durable, anti-fouling, crosslinked zwitterionic coatings that are grafted to the surface of a substrate through covalent bonding are disclosed. When exposed to a light source, zwitterionic monomers react with a crosslinker and with activ...
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JP7004567B2 |
A polymer resin composition is disclosed including a chemically attached lubricant structure to produce a self-lubricating medical device thereby eliminating the need of a secondary lubrication step currently required which is useful in ...
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JP2022508521A |
A medical device comprising an expandable tubular body configured to be implanted in a lumen and having a polymer (s) bonded to an outer surface is described. [Selection diagram] None
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JP2022506110A |
The present invention provides compounds that inhibit Factor XIa or kallikrein, and pharmaceutically acceptable salts thereof and compositions thereof. The present invention also provides methods of making these compounds or pharmaceutic...
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JP6996556B2 |
An article used in contact with a living body or a biological sample is provided, the article including a first film and a second film, in which the first film includes an amorphous carbon film in which a proportion of the number of carb...
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JP2022506109A |
Compounds and compositions that inhibit Factor XIa or kallikrein, as well as methods of using these compounds and compositions, are provided herein. The present invention relates, in part, to novel forms of compounds that inhibit Factor ...
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JP6993322B2 |
An intravenous delivery system may have a plurality of components with interior surfaces that cooperate to define a fluid pathway through which fluid flows into a body of a patient. One or more anticoagulant coatings may reside on one or...
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JP2022504294A |
In particular, it is an anticoagulant surface, the surface of which is covalently attached to a plurality of heparin fragments, wherein the fragment consists of 5-18 sugar units and at least a portion of the plurality of fragments is a p...
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JP2021193164A |
To provide a polycarbonate resin material which is excellent in antithrombogenicity and heat resistance, and is reduced in an eluted material.A resin material contains a terminal group structure represented by the following formula (1) i...
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JP2021534906A |
The present invention seeds human arterial endothelial cells that are suitable for replacing or creating bypasses with natural blood vessels and exhibit increased long-term patency and reduced leukocyte adhesion compared to grafts contai...
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JP2021534878A |
The vascular device (1) for insertion into the body lumen (7) includes a surface (111), and at least a portion of the surface (111) has the vascular device (1) inserted into the body lumen (7). Then, there are more than two charged ions ...
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JP2021533892A |
Zwitterion dual network hydrogels, methods for making zwitterion dual network hydrogels, methods for using zwitterion dual network hydrogels, and methods made from zwitterion dual network hydrogels, and Articles coated by this.
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JP2021533886A |
The present invention relates to implants, particularly intravascular implants, wherein the implant comprises a degradable body; a first degradable coating containing at least one degradable polymer; and a growth inhibitory active agent,...
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JPWO2020158847A1 |
The present invention makes it possible to maintain antithrombotic properties by early endothelialization of a special knitted tissue made of a multifilament containing ultrafine fibers, and has improved cardiovascular storage in a sheat...
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JP6962901B2 |
The present invention relates to immobilized biologically active entities that retain significant biological activity following mechanical manipulation of a substrate material to which the entities are immobilized. The significant biolog...
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JP6954529B2 |
To provide a gelling composition that causes a phase transition from a state with flowability to a state without flowability by an unconventional mechanism and has excellent handleability, and provide a gel structure from the gelling com...
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JP2021526901A |
Multi-factor vascular stents can be used to maintain or strengthen vascular patency. Stents can be used in peripheral vessels that can be long and / or meandering. By using multiple separate balloon-expandable stent elements, a multi-fac...
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JP6944687B2 |
To provide contact type materials with an organism in which a cell can be processed without having a form change of an animal cell.Contact type materials includes a co-immobilized surface comprising a polymer: PEG-b-(MTP-r-CMS) represent...
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JP2021525221A |
The present invention relates to ticks for inhibiting exogenous coagulation pathways and for treating and / or preventing diseases and conditions associated with neutrophil recruitment and activation after activation of exogenous coagula...
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JP6916353B1 |
To provide a polymer composition for preventing adhesion. An adhesion-preventing polymer composition according to the present invention has excellent adhesion performance so that it can be continuously and well adhered to a wound site ge...
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JP6916193B2 |
The present invention aims to provide a method for producing a porous substrate containing a bioabsorbable polymer and heparin in a simple manner without use of a surfactant, a porous substrate containing a bioabsorbable polymer and hepa...
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JP6909226B2 |
Various embodiments relate to catheter locking solutions and catheter locking therapies with use of trisodium citrate and ethyl alcohol, and in particular 4.0 to 15.0 weight/volume % trisodium citrate as an anticoagulant component and/or...
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JP2021101750A |
To provide a medical tool having excellent slipperiness (especially piercing characteristics), and capable of exhibiting excellent antithrombogenicity.A medical tool has a patchy structure including protrusions formed on a surface thereo...
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