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JP3342482B2 |
A novel polysaccharide derivative prepared by replacing part or the whole of the hydroxyl or amino groups of a polysaccharide by two or more different substituents, and a separating agent and a separator both containing this derivative. ...
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JP3343256B2 |
The invention relates to 3,3-diphenylpropylamines of formula (I), wherein R1 signifies hydrogen or methyl, R2 and R3 independently signify hydrogen, methyl, methoxy, hydroxy, carbamoyl, sulphamoyl or halogen, and X represents a tertiary ...
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JP3342012B2 |
The present invention relates to a new isoindolinone derivative of formula: (I) in racemic form or in the form of its enantiomers, as well as its salts, its preparation and the pharmaceutical compositions which contain it.
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JP2002537282A |
The invention relates to novel substituted 3-phenoxy or 3-phenylalkyloxy-2-phenyl-propylamines of general formula (1), to methods for producing them and to their use as medicaments.
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JP2002316966A |
To provide a new binaphthol derivative useful as a raw material for a catalyst for an asymmetrical synthesis.This binaphthol derivative is the one represented by general formula 1 [Y1, Y1', Y2 and Y2' are each a carboxy group, an esterif...
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JP2002316960A |
To provide a new host compound having a structure different from those of conventionally well-known ones.This new clathrate compound (salt) is shown by the formula (1) (wherein, R1 and R2 are each a substituent; m and n are each an integ...
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JP2002536427A |
The invention relates to a method for the racemization of optically active amines by reacting the optically active amine in the presence of hydrogen and of a hydrogenation or dehydrogenation catalyst at an elevated temperature. According...
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JP2002534404A |
Novel 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives, use of substituted 4-Biarylbutyric and 5-Biarylpentanoic Acid Derivatives as Matrix Metalloprotease Inhibitors for the Treatment of Respiratory Diseases, pharmaceutical compos...
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JP3334263B2 |
PURPOSE: To prepare an optically active amino acid derivative containing a sulfoxide capable of providing an adsorbent for chromatographic resolution affording improved resolution results. CONSTITUTION: This compound is represented by fo...
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JP2002293805A |
To provide a method for producing an O-alkyl substituted polysaccharide derivative efficiently and in high purity and to provide a method for producing an optically active substance using the derivative obtained by the method.The method ...
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JP2002293761A |
To provide a high purity isomer from a mixture of isomers continuously in a high productivity.This method for adsorbing and separating isomers by bringing a discriminating liquid consisting of a discriminating agent having molecule- disc...
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JP2002293751A |
To provide a method for continuously producing a high-purity optically active substance without causing decline in its separatory performance even under the continuous production process.This method for producing an optically active subs...
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JP2002275131A |
To provide a method for producing an optically active 2-aminotetralin derivative, involving converting the unnecessary isomer after optical resolution to the racemic form to put it to recycling use as the raw material for the optical res...
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JP2002531429A |
A process for preparing a substantially single enantiomer of tramadol, or a pharmaceutically-acceptable salt thereof, proceeds by means of a classical salt resolution using a substantially single enantiomer of O,O-di-p-toluoyltartaric ac...
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JP2002531595A |
The present invention relates to chiral esters of polysaccharides, preferably of cellulose, amylose, beta-cyclodextrin or amylopectin, obtained by reacting, in basic medium, polysaccharides (polyhydroxylated compounds) with racemic or en...
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JP2002265467A |
To provide a thiacalix[4]arene derivative which has an optically active cage type molecular skeleton and is useful as a sensor, an analysis reagent, an analysis medium, a catalyst ligand, and the like, and to provide a method for produci...
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JP3326174B2 |
The use of S(-)sodium 2-(4-isobutylphenyl)-propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(-)sodium 2-(4-is...
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JP2002529431A |
The invention concerns a resolution method for a racemic mixture of aldehyde of formula (I).The aldehydes of formula I are useful in their enantiomeric form or their racemic form for preparing transition metal complexes useful as catalys...
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JP2002249462A |
To provide a method for separating (1R, 1'S, 3R, 3'S, 4S, 4'R)- dicyclohexyl-3,3',4,4'-tetracarboxylic acid dimethylester at a stage of cis- dicyclohexyl-3,3',4,4'-tetracarboxylic acid dimehylester (semiester).The method for separating c...
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JP2002528435A |
This invention encompasses a novel process for synthesizing compounds represented by formula A:These compounds are intermediates useful in the preparation of certain agents that are selective COX-2 inhibitors.
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JP2002241318A |
To provide a method for producing an optically active 2-amino-1- acenaphthenol derivative.This method for producing the optically active 2-amino-1- acenaphthenol derivative is characterized by performing an optical resolution of a racemi...
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JP2002241317A |
To provide a new comb-formed polymer having an excellent optical activity-recognizing function useful as a filler for a high speed liquid chromatography excellent in resolution function of racemic materials, easily prepared and produced ...
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JP2002241316A |
To provide a method for producing an optically active chrysanthemic acid alkyl ester.This method for producing an optically active chrysanthemic acid alkyl ester is characterized by comprising making an optical resolution of a chrysanthe...
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JP2002527500A |
The invention concerns intermediates of formula or wherein R 5 is alkyl or alkenyl of one to ten carbons. Preferably, R 5 is isobutyl.
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JP2002526468A |
(±)-alpha-(Difluoromethyl)-ornithine is separate into its isomers using (-)-O,O'-di-p-toluoyl-L-tartaric acid. (-)-alpha-(Difluoromethyl)-ornithine monohydrochloride monohydrate and in particular the (-)-isomer are inhibitors of ornithi...
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JP2002526461A |
The invention concerns LTA4 hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.
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JP3316234B2 |
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JP2002525351A5 |
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JP3312459B2 |
PURPOSE: To obtain an industrially practicable process for the separation of an optically active amine having high affinity to water. CONSTITUTION: The characteristic of this process for the separation of an optically active amine proces...
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JP3312453B2 |
PURPOSE: To produce an optically active trans DACH suitable for industrial use from a mixture containing cis DACH and trans DACH and available as an inexpensive raw material. CONSTITUTION: This process for the production of an optically ...
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JP3312454B2 |
PURPOSE: To provide a method for recovering optically active tartaric acid from a diastereomer salt obtained by optical resolution, suitable for industrial production. CONSTITUTION: In subjecting a racemic amine to optical resolution by ...
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JP3312451B2 |
PURPOSE: To produce optically active trans-DACH by an industrially suitable process from a mixture containing cis-DACH and trans-DACH and available as an inexpensive industrial raw material. CONSTITUTION: An optically active trans-1,2-di...
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JP3312452B2 |
PURPOSE: To produce an optically active DACH suitable for industrial production from a diastereomer salt obtained by optical resolution. CONSTITUTION: An optically active trans-1,2-diaminocyclohexane consisting of (R,R)-1,2-diaminocycloh...
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JP2002212111A |
To provide a method for efficiently optically resolving a racemate in the field of medicines, agrochemicals, perfumes, or a biochemistry-related industry.This optical resolution method comprises using a DNA as an optical resolving agent ...
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JP2002523396A |
The present invention relates to novel amino acid esters of arylsulphonamides and analogues, to processes for their preparation and to their use for the prophylaxis and treatment of neurodegenerative disorders, in particular for the trea...
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JP2002523396A5 |
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JP3307641B2 |
PCT No. PCT/EP93/00196 Sec. 371 Date Jun. 7, 1994 Sec. 102(e) Date Jun. 7, 1994 PCT Filed Jan. 9, 1993 PCT Pub. No. WO93/16035 PCT Pub. Date Aug. 19, 1993.A process for the resolution of racemic verapamil which comprises reacting the fre...
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JP2002522515A |
The present invention relates to a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic, chiral cata...
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JP2002522430A |
In the 2 Θ diffractogram of an enantiomerically pure crystalline (R)- or (S)-lipoic acid, the most intense reflection line in the range from 13° to 30° is that at 2 Θ=23°.
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JP3304419B2 |
PURPOSE: To carry out optical resolution of a (RS)-1-(4-halogenophenyl) ethylamine in an industrially advantageous way using, as optically resolving agent, a stable, specific optically active compound which can be obtained in high yield ...
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JP2002521358A |
The present invention relates to alpha-amino acid phenyl ester derivatives having general formula (I) wherein R1 is (C1-3)alkyloxy; R2 is (C1-3)alkyl, (C1-3)alkyloxy or (C2-3)alkenyl; R3 is hydrogen, (C1-3)alkyl, (C1-3)alkyloxy or (C2-3)...
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JP2002193933A |
To obtain an optically active piperidine derivative, especially optically active 3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine or its acid salt with high optical purity in high yield.The production method of the optically active piperi...
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JP2002193901A |
To provide a simple method of obtaining high purity (1S,4R)-4-amino-2- cyclopentene-1-carboxylic esters or (1R,4S)-4-amino-2-cyclopentene-1-carboxylic esters in high yield.The method of optical resolution of a (1S*,4R*)-4-amino-2- cyclop...
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JP3299747B2 |
A process for the separation of a racemic mixture of certain aliphatic carboxylic acids or esters thereof is disclosed. The process comprises: i) separating a racemic mixture of an aliphatic carboxylic acid or ester thereof having the fo...
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JP3300712B2 |
PURPOSE: To obtain the subject compound by adding a racemization promoting agent to a solution of a racemic mixture of 2,2-dimethyl-5-phenyl-1,3-dioxolan-4- one and seeding the solution with a crystal of the objective optically active su...
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JP2002187875A |
To provide a method for efficiently producing (S)-2-amino-5- methoxytetralin by using 5-methoxy-2-tetralone as a starting raw material.5-Methoxy-2-tetralone is reductively aminated with ammonia in a proper solvent in the presence of a ca...
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JP2002519419A |
A process for producing compounds of formula (1.0) is disclosed. The compound of formula (1.0) is produced by: (1) separating the atropisomers of (2.0) to obtain the atropisomers (2.0A) and (2.0B); (2) heating the atropisomer of formula ...
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JP2002179692A |
To provide a process for preparing new and known diphosphines through intermediates (some thereof are new).Phenol is converted into a phenoxide to form a formaldehyde acetal, which is then converted into a cycloheptadiene. The resultant ...
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JP2002166146A |
To develop an optical resolution membrane cell capable of carrying out optical resolution within a short time with a small amount of the solvent and provide an optical resolution method using the cell.The optical resolution cell is provi...
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JP3288109B2 |
PURPOSE: To efficiently obtain an optical isomer as a raw material for organic syntheses or as e.g. an optically separatory agent, by bringing an optical isomer mixture of e.g. bis-β-naphthol, bisphenanthrol into contact with an optical...
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