| Document |
Document Title |
|
WO/2007/023811A1 |
[PROBLEMS] To provide a method for preparing a heavy atom derivative of a protein crystal in a simple manner with high probability, a method for collecting phase information, and a method for determining a three-dimensional structure of ...
|
|
WO/2007/021858A2 |
The present disclosure relates to a solid-phase process for the production of radiolabeled tracers, in particular for the production of 18F-labeled compounds which may be used as Positron Emission Tomography (PET) radiolabeled tracers. T...
|
|
WO/2006/136846A1 |
The invention provides a compound of formula (I); or a salt or solvate thereof, wherein: R1 is hydrogen or C1-4alkyl; R2 and R4 are each independently selected from C1-4 alkyl, [11C] C1 4alkyl, and [18F]-C1-4 fluoroalkyl provided that at...
|
|
WO/2006/133732A1 |
The main objectives of the invention are notably: the shrinkage of the process time because of the low half-life of [18F]FLT, as well as the increase of the yield, especially without HPLC purification which is a complex and a time consum...
|
|
WO/2006/134424A2 |
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with water pretreated by a base are provided. The resultant carbon-isotope labeled acids are useful as radiopharm...
|
|
WO/2006/134474A2 |
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with sulfoxides and triethylamine are provided. The resultant carbon-isotope labeled acids, and pharmaceutical ac...
|
|
WO/2006/131803A2 |
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols or water treated by photosensitizers are provided. The resultant carbon-isotope labeled esters and ...
|
|
WO/2006/127024A1 |
In one aspect, the present invention provides a method for labeling a terminal olefin, the method comprising a step of treating a terminal olefin substrate having the structure: Formula (I); with a labeled ethylene reagent in the presenc...
|
|
WO/2006/121035A1 |
[PROBLEMS] To provide a process by which a compound comprising an aromatic compound having a radioactive-halogen substituent and an amine or phosphine bonded thereto can be produced in a practicable yield. [MEANS FOR SOLVING PROBLEMS] A ...
|
|
WO/2006/103509A2 |
Methods and reagents for transition metal-promoted carbonylation via diazo compounds using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially...
|
|
WO/2006/100481A2 |
A process for the preparation of 11C methyl iodide comprises coating the internal surface of a first reaction vessel with a solution of lithium aluminium hydride, wherein the first reaction vessel has an internal diameter not greater tha...
|
|
WO/2006/100563A1 |
Methods and reagents for transition metal-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuticals, especially for ...
|
|
WO/2006/092902A1 |
A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R1 represents a group such as an alkyl group; X1, X2, X3 and X4 represent each a hydrogen atom, an alkyl group, an alkoxy group, an al...
|
|
WO/2006/082497A1 |
Methods and reagents for thermally initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with nucleophiles are provided. The resultant carbon-isotope labeled compounds are useful as radiopharmaceuti...
|
|
WO/2006/080202A1 |
[PROBLEMS] To provide a method for producing deuterium gas, which can efficiently generate deuterium gas for a deuterated solvent that is a reaction substrate. [MEANS FOR SOLVING PROBLEMS] (1) A method for producing deuterium gas charact...
|
|
WO/2006/072336A2 |
The invention relates to specific radioactive metal complexes based on bispidine and the derivatives thereof as chelating agents, the use thereof for nuclear medical diagnosis and therapy, and to a method for producing radioactive metal ...
|
|
WO/2006/071138A1 |
The invention relates to a tritium-traced syxitoxin dihydrichloride of formula (I) whose radioactivity ranges from 15-31 Ci/mmol and to a novel method for introducing tritium into a molecule comprising stages required for introducing tri...
|
|
WO/2006/068015A1 |
[PROBLEMS] To prevent the formation of impurities caused by the decomposition of a substrate in the process of producing a radioactive fluorine-labeled compound. [MEANS FOR SOLVING PROBLEMS] A method of producing potassium [18F] fluoride...
|
|
WO/2006/067376A2 |
The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a vector such as a peptide comprising reaction ...
|
|
WO/2006/064349A1 |
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using alkyl/aryl iodides with alcohols pretreated by a base are provided. The resultant carbon-isotope labeled esters are useful as radiop...
|
|
WO/2006/053785A1 |
The present invention relates to radiolabelled compounds of formula (I), which are useful for the labelling and diagnostic imaging of 5-HT6 receptor functionality, and the treatment of CNS related disorders.
|
|
WO/2006/051428A2 |
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using weakly nucleophilic amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharm...
|
|
WO/2006/045886A1 |
A method provides obtaining a product substrate comprising at least one hydrogen isotope, the isotope comprising at least one neutron. The method comprises feeding a compound of the at least one isotope and a substrate to at least one pr...
|
|
WO/2006/037950A1 |
The invention provides a method for the synthesis of an 18F-labelled product comprising deprotected of a protected 18F-labelled compound using a deprotection agent comprising a weak acid and wherein neutralisation and buffering of the de...
|
|
WO/2006/001236A1 |
This invention provides a method for deuterating a haloacrylic acid or its salt with high efficiency on a commercial scale. The method is characterized in that a compound represented by general formula [1] wherein R1 and R2 each independ...
|
|
WO/2005/120584A2 |
The present invention relates to Radiolabeled Arylsulfonyl Compounds and methods of use thereof as imaging agents for the COX-2 enzyme using positronemission tomograpy (PET). Methods of making the Radiolabeled Arylsulfonyl Compounds an...
|
|
WO/2005/121315A1 |
The invention concerns the production of cholesterol in organisms of the Fungi kingdom. More particularly, the invention concerns genetically modified Fungus independently producing cholesterol from a simple carbon source. The invention ...
|
|
WO/2005/115971A1 |
Disclosed is a radioactive tyrosine derivative represented by the formula (I) below or a pharmaceutically acceptable salt thereof. (In the formula, R1 represents a group selected from the group consisting of -11CH3, -11CH2CH3, -CH218F an...
|
|
WO/2005/113471A1 |
A method of labeling one or the two oxygen atoms of the carboxy group of a carboxylated compound with an oxygen isotope which is either oxygen of mass number 17 (17O) or oxygen of mass number 18 (18O). The method is characterized in that...
|
|
WO/2005/108330A1 |
The aim of the invention is to provide radiolytically and metabolically stable metal complexes, which are suitable for conjugation with biomolecules and to provide a method for their production. This is achieved by metal complexes based ...
|
|
WO/2005/107819A2 |
The invention relates to novel processes for the purification of radiolabelled tracers, using a solid-support bound scavenger group. The general concept being illustrated by the scheme :
|
|
WO/2005/105708A1 |
This invention relates to novel 15O-labeled monosaccharide useful for positron emission tomography (PET) and producing method thereof.
|
|
WO/2005/097713A1 |
A method for the fluoridation of an iodonium salt with a fluoride ion source which can be carried out in an aqueous reaction solvent.
|
|
WO/2005/092820A2 |
Various 13C and 14C carbon labeled compounds Rf-bCF(U)y(T)z Formula 1A or Rf-bCF2bCF(U)y(T)z Formula 1B wherein Rf is a linear or branched perfluoroalkyl radical Z(CmF2m)-, m is 1, 3 to 20, or a mixture thereof; Z is F when m is 1, and Z...
|
|
WO/2005/090266A1 |
Radiolabelled acid chlorides may be synthesised by reacting a radiolabelled carboxylic acid with a solid-phase supported chlorinating agent.
|
|
WO/2005/090268A1 |
The present invention provides a radiolabeled ligand which is highly selective and potent for glutamate transporters and is usable in specifically detecting the glutamate transporter. Specifically, the present invention provides a 3-[3-(...
|
|
WO/2005/090267A2 |
Methods and reagents for labeling synthesis of organohalides by transition metal mediated carbonylation reactions using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled organohalides are useful as...
|
|
WO/2005/079864A2 |
The present invention relates to a method for preparing mercaptoacetyl triglycine labeled with a radionuclide, comprising the steps of adding a radionuclide to a solution that comprises a mercaptoacetyl triglycine dimer of formula VI, a ...
|
|
WO/2005/077967A1 |
Positron emitting compounds and methods of their production are provided. The compounds have the formula: (F)m G (R)n wherein each R is a group comprising at least one carbon, nitrogen, phosphorus or sulfur atom and G is joined to R thro...
|
|
WO/2005/075486A1 |
Provided are methods for synthesizing radiotracers, including no carrier added (n.c.a.) tracers suitable as PET scan tracers that contain a 18F-P bond. The radiolabeled products may be synthesized from precursors including phosphorus(V) ...
|
|
WO/2005/070853A1 |
A method of deuteration in which a compound with aromatic ring and/or heterocycle having an enhanced deuteration ratio can be obtained. There is provided a method of deuterating a compound with aromatic ring and/or heterocycle, character...
|
|
WO/2005/066100A1 |
Methods and reagents for synthesizing carbon-isotope labeled ketones and amines by carbonylation via Suzuki coupling reaction using carbon-isotope labeled carbon monoxide are provided. The resultant carbon-isotope labeled ketones and ami...
|
|
WO/2005/061445A1 |
Methods and reagents for rhodium-promoted carbonylation via isocyanate using carbon-isotope labeled carbon monoxide are provided. The resultant carbon isotope labeled compounds are useful as radiopharmaceuticals, especially for use in ...
|
|
WO/2005/061415A1 |
Decomposition of iodonium salts by a free radical process has been identified as a significant factor in the observed yield variability of fluoridation reactions using said iodonium salts. Accordingly, the inclusion of a free radical tra...
|
|
WO/2005/054132A1 |
The present invention relates to the indentification of polymeric materials. More, particularily, the present invention relates to tagged polymeric materials and methods for tagging said polymeric materials, the component comprising iner...
|
|
WO/2005/054128A2 |
Methods and systems for labeling synthesis of phosgen by UV light are provided. Methods of synthesizing labeled compounds useful as PET tracers from labeled phosgen are also provided. The resultant carbon-isotope labeled compounds are us...
|
|
WO/2005/050226A1 |
This invention provides fluorous-based methods and compositions for preparation, separation and analysis of complex biologically-derived samples, such as proteomic and metabolomic samples.
|
|
WO/2005/044758A1 |
An on-column process by which various radioactive-fluorine-labeled compounds can be obtained in a high yield. The process comprises a step in which [18O]water containing [18F]fluoride ions is introduced into a column packed with an anion...
|
|
WO/2005/045850A2 |
The invention relates to radioactive arsenic triiodide of formula *Asl3, wherein * represents 70, 71, 72, 74, 76 or 77. The invention also relates to a method for radioactive marking of organic compounds, whereby at least one reactive gr...
|
|
WO/2005/042441A1 |
Methods and reagents for photo-initiated carbonylation with carbon-isotope labeled carbon monoxide using amines and alkyl/aryl iodides are provided. The resultant carbon-isotope labeled amides are useful as radiopharmaceuticals, especial...
|
