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WO/1994/026275A1 |
2-Pyridylmethylenepolyazamacrocyclophosphonic acid compounds and their derivatives are disclosed which may form inert complexes with Gd, Mn or Fe ions. The overall charge of the complex can be varied to alter the in vivo biolocalization....
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WO/1994/023757A1 |
Radioactive metallocene carboxylic acids and their derivates having formula (I), in which R1, R2, R3, R4 and R5 have different meanings and M stands for a radioactive metal isotope of the elements having the atomic numbers 21-29, 31, 42-...
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WO/1994/022816A1 |
Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have formula (a) and (b), where A, A' = -SZ or Y, B = O or S, Y = (c), Z = H or a thiol pro...
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WO/1994/022495A1 |
Tetralin derivatives, such as 7-hydroxy-2-(N-n-propyl-N-3'-iodo-2'-propenyl)amino]tetralin
and 8-hydroxy-2-(N-n-propyl-N-3'-iodo-2'-propenyl)amino-tetralin
, are disclosed which have affinity and specificity for dopamine D-3 and/or sero...
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WO/1994/022494A1 |
This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using sai...
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WO/1994/022497A1 |
Novel bifunctional chalcogenic-atom-discontinuous chelating agents, pharmaceutical preparations containing them, their use in radio diagnosis and radio therapy, and methods of preparing them. The invention concerns compounds of the gener...
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WO/1994/018339A1 |
A method for determining three-dimensional structural information of a protein involves producing the protein in a form substantially labeled with 13C or 15N or both or substantially labeled with 15N and 13C and partially labeled with 2H...
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WO/1994/017016A1 |
In one aspect the invention relates to the preparation of deuterated sevoflurane and its use as an inhalation anesthetic. In a further aspect the invention relates to the minimization of degradation of sevoflurane to F2-C = C(CF3)OCH2F (...
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WO/1994/014477A1 |
The invention relates to polyhydric phenol compounds of general formula (I), wherein R is a hydrogen atom or a saccharide moiety; A and B are hydrogen atoms or form together a C-C bond; R1 is a hydroxy group and R2 is a hydrogen atom, or...
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WO/1994/010172A1 |
A group of novel expanded porphyrin-like compounds, porphacyanine (Pc) and porphacyanine-like compounds, having absorption maxima in the range of 400-850 nanometers is useful in detecting and treating targeted tissues, cells and viruses....
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WO/1994/008949A2 |
The invention concerns novel metal chelating compounds, and radiometal, e.g. technetium-99m complexes thereof. The compounds can be used to radiolabel small biologically active species with minimal effect on their biodistribution and act...
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WO/1994/007894A1 |
Porphyrine-complex compounds consisting of a ligand of formula (I) and at least one ion of an element of atomic number 21-32, 37-39, 42-51 or 57-83, wherein R2 stands for R3, a -CO-Z group or a -(NH)o-(A)q-NH-D group, R3 stands for a -(C...
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WO/1994/002456A1 |
Hydroxyphenylthioalkyl amines represented by formula (I), wherein R1 is H or C1-C8 alkyl; R2 is H or C1-C8 alkyl; R3 is H, C1-C8 alkyl or C1-C8 alkanoyl; R4 is H or C1-C8 alkanoyl; Ra is a radioactive material useful in radioimaging and/...
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WO/1994/002462A1 |
Piperidinyl substituted benzamides of formula (I) the pharmaceutically acceptable acid addition salts thereof and the stereoisomeric forms thereof, wherein R1 is hydrogen or halo; R2 is halo; R3 is hydrogen or halo; R4 and R5 each indepe...
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WO/1994/001426A1 |
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
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WO/1994/000460A1 |
A protected 6-trimethylstannyl dopa derivative has been synthesized for the as a precursor for the preparation of 6-[18F]fluoro-L-dopa. The tin derivative readily reacts with electrophilic radiofluorinating agents such as [18]F2, [18F]OF...
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WO/1993/025566A1 |
The preparation of deuterated nucleoside and nucleotide units for RNA and DNA synthesis is described. Preparation of the deuterated sugar residue is also described. The deuterated units are used to synthesize strands of RNA and DNA where...
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WO/1993/022260A1 |
Additives are proposed for compositions comprising radiolabelled organic compounds e.g. 32P-labelled nucleotides. Stabilisers are selected from tryptophan, para-aminobenzoate, indoleacetate and the azole group. Dyes are selected from Sul...
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WO/1993/021963A2 |
A group of functionalized polyaminocarboxamide modified chelators that form complexes with rare earth-type metal ions are disclosed. The complexes, covalently attached to an antibody or antibody fragment, can be used for therapeutic and/...
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WO/1993/022681A1 |
The present invention provides methods for screening drug compounds utilizing compounds of formulas (I and II), and the pharmaceutically acceptable salts thereof where: R1, R2, R3, and R4 represent hydrogen, halogen, alkyl or alkoxy subs...
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WO/1993/019787A1 |
Radiopharmaceuticals for imaging myocardial tissues are prepared by forming lipophilic, cationic complexes of radioactive metal ions with metal chelating ligands comprising the Schiff base adducts of triamines and tetraamines with option...
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WO/1993/015770A1 |
The present invention relates to novel ligands and labelling techniques. The present invention further relates to a diagnostic composition suitable for administration to a warm-blooded animal comprising somatostatin or hirudin or a molec...
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WO/1993/015771A1 |
Amide-thiolate ligands having improved metal chelate formation kinetics are disclosed. The ligands include an amine to facilitate rapid formation of an amine-amide-thiolate intermediate complex, followed by transfer of the metal to or co...
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WO/1993/015093A1 |
A method is provided utilizing contrast agents which provide increased diagnostic information in the magnetic resonance image of the hepatobiliary system and alimentary tract, especially the small intestine. Novel contrast agents which a...
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WO/1993/013800A1 |
The composition of a new radiopharmaceutical for use as a tumor imaging agent comprising methyl glyoxal Bis (guanyl hydrazone), SnCl2.2H2O, and 99mTc in the form of 99mTcO-4, obtained from a generator and formulated in a mixture for use ...
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WO/1993/011801A1 |
Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. 153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115mIn ion, are discl...
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WO/1993/011871A1 |
The present invention relates to an apparatus for the manufacturing of radioisotope labelled chemicals and pharmaceuticals, said apparatus comprising a first, disposable module (21-35, 54) supporting all of the components which are at ri...
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WO/1993/012112A1 |
Complexes of bicyclopolyazamacrocyclocarboxylic acid compounds with a metal ion, e.g. 153Sm, 177Lu, 159Gd, 149Pm, 140La, 175Yb, 166Ho, 90Y, 47Sc, 186Re, 188Re, 142Pr, 99mTc, 67Ga, 68Ga, 105Rh, 97Ru, 111In, 113mIn or 115mIn ion, are discl...
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WO/1993/010747A2 |
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targete...
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WO/1993/010823A1 |
The present invention relates particularly to novel aminothiol ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
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WO/1993/009814A1 |
Novel compounds show high affinity for specific cocaine receptors in the brain, particularly dopamine transporter sites, and have formula (I), wherein Y = CH2R3, CO2R2 or (II), R1 = hydrogen, C1-5 alkyl, R2 = hydrogen, C1-6 alkyl, C3-8 c...
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WO/1993/008839A1 |
A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, o...
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WO/1993/009076A1 |
A method for introducing one or two radioactive iodine isotopes into the 3-position or 3,5-positions of the $g(a)-ring of an iodo thyronine compound, an iodo thyronamine compound or a thyro carboxylic acid, comprising the preparation of ...
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WO/1993/006092A1 |
Compounds according to structural formula (I), wherein R?1¿ is (1) hydrogen, (2) alkoxycarbonyl or (3) unsubstituted or substituted alkyl wherein said substituent is hydroxyl, alkoxyl, carboxyl, carboxyalkyl, alkylsulfonyl or alkoxycarb...
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WO/1992/021379A1 |
Radioactive high molecular weight metal-binding protein compositions and a method for therapeutic radiation treatment including the treatment of rheumatoid arthritis comprising injection of a radioactive high molecular weight metal-bindi...
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WO/1992/020674A1 |
The invention provides compounds of general formula (I), or a physiologically acceptable salt, solvate or metabolically labile ester thereof wherein R1 represents a hydrogen atom or a halogen atom or a group selected from C1-6alkyl, C2-6...
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WO/1992/019210A2 |
Disclosed are novel compounds for CNS neurotransmitter systems, especially for the neurotransmitter serotonin, which have formula (I), where each of U, V, W, X, Y and Z is independently selected from the group consisting of hydrogen; hal...
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WO/1992/015333A1 |
A method for attaching technetium-99m to proteins using reducing metal reagents to achieve binding to high affinity binding sites and high specific activity. The reagents play a dual role under the given experimental conditions by reduci...
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WO/1992/014492A1 |
The present invention relates to a process of making radiopharmaceuticals in situ, i.e. wherein a radionuclide and an acyclic ligand react with constituents of the complex forming reaction solution to produce an administratable radiophar...
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WO/1992/013826A1 |
Compositions and method for therapeutic and/or diagnostic treatment of soft tissue tumors in mammals using certain metal ions or particle-emitting radionuclides complexed with a phenolic carboxylate ligand is described.
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WO/1992/013572A1 |
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind technetium-99m and which can be...
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WO/1992/011040A2 |
A myocardial imaging agent for use in humans comprising a TC(III) complex ligated in a planar position by a tetradentate ligand having incorporated therein four hard atoms and two furanome rings and in the axial positions by phosphines c...
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WO/1992/010466A1 |
The present invention relates particularly to novel preorganized hexadentate ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes. They have general formula (I), w...
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WO/1992/006068A1 |
Applicants describe the synthesis of tamoxifen derivatives, most particularly halo, halo alkyl and hydroxy tamoxifen derivatives, wherein with the native tamoxifen molecule includes a substituted chemical group positioned on the aliphati...
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WO/1992/005154A1 |
The present invention relates particularly to novel aminothiol ligands that are suitable for complexing with a radionuclide, and are useful as general imaging agents for diagnostic purposes.
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WO/1992/005128A1 |
A process is disclosed for producing compounds having formula (I), in which n = 1, 2 or 3, by reaction of compounds having formula (V), in which R?12¿ is a hydrogen or deuterium atom, with equimolar amounts of a base in water or an orga...
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WO/1992/001673A1 |
Compounds of formulae (1), wherein R represents a CH3 or CD3 group; R1 represents an alkyl group; R2 represents an alkyl or aryl group; and N may be either an 14N or 15N atom, with the proviso that when R represents CD3, the methylene an...
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WO/1992/001688A1 |
Quinuclidine derivatives of formulae (I), (II) or (III) and the pharmaceutically acceptable salts thereof, wherein m, P, Z, Y, R1, R2 and R3 are as defined below. The compounds are substance P antagonists and, therefore, are useful in tr...
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WO/1992/000758A1 |
The invention relates to a method of preparing a solution of a radioactive rhenium complex, by reacting at elevated temperature a radioactive perrhenate in a substantially aqueous solution with a ligand in the presence of a reductant and...
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WO/1992/000982A1 |
Process for the preparation of transition metal nitrido complexes for use as radiopharmaceutical products or for the synthesis of novel pharmaceutical products. The process consists in reacting an oxygenic transition metal compound such ...
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