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Matches 1 - 50 out of 6,962

Document Document Title
WO/2019/153954A1
Disclosed are a multi-substituted benzene compound having biological activity, a preparation method therefor, and an application thereof. The compound of the present invention has good biological activity and the activity of inhibiting t...  
WO/2019/157195A1
The present invention relates to using monoterpene or sesquiterpene to permeabilize the blood brain barrier.  
WO/2019/144805A1
Provided are a substituted phenylethylamine compound as a μ opioid receptor agonist, a pharmaceutical composition comprising same, a preparation method therefor and the use of same for preventing and/or treating diseases associated with...  
WO/2019/141095A1
A compound represented by formula (I), a pharmaceutical composition, a pharmaceutical formulation and use of the compound in the preparation of a medicament for preventing or treating diseases associated with IDO activity or IDO mediated...  
WO/2019/143495A1
Processes are described for separating 3,4'- and 4,4' -dimethylbiphenyl from a mixture comprising at least 3,3'-, 3,4'- and 4,4' -dimethylbiphenyl. In the processes, the mixture is cooled to produce a crystallization product comprising a...  
WO/2019/127921A1
The present invention relates to a compound for a polypeptide liquid-phase synthesis carrier, a preparation method therefor and use thereof. Specifically, disclosed is a cyclic ketone compound as a polypeptide liquid-phase carrier, havin...  
WO/2019/127919A1
The present invention relates to a carrier compound for liquid phase synthesis of a polypeptide, a preparation method therefor and use thereof, and specifically discloses a fused ring compound which can be used as a liquid phase carrier ...  
WO/2019/132210A1
A method for preparing cyclododecene and a synthesis device therefor, of the present invention, remarkably increase the conversion ratio of cyclododecatriene and selectivity of cyclododecene, can minimize the costs required for equipment...  
WO/2019/110299A1
Proposed is a process for producing rotundone from α-guaiene, in particular by oxidation of the C(3) position, wherein the α-guaiene is produced from a precursor by a sesquiterpene synthase. The sesquiterpene synthase is produced in a ...  
WO/2019/108943A1
The present disclosure provides a benzene fused heterocyclic compound of Formula (I): wherein (A) is a single or double bond; n is 0 or 1; X is -CH2-, O, NR1, or S; A is -C(Ra1)(Ra2)(Ra3) or -N(Ra1)(Ra2), wherein Ra1, Ra2 and Ra3 are ind...  
WO/2019/101813A1
The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to malodor counteracting compositions and/or ingredients, methods for counteracting malodors, as well a...  
WO/2019/101926A1
A method comprising catalysis of the conversion of (+)-cis-isopulegone to (R)-(+)-pulegone using a ketosteroid isomerase is disclosed. A mutated ketosteroid isomerase having (+)-cis-isopulegone to (R)-(+)-pulegone isomerase activity is a...  
WO/2019/095052A1
The present application relates to methods and uses of CB2 target agent local anaesthetics such as beta-caryophyllene for treatment of interstitial cystitis in a subject, optionally together with the administration or use of an additiona...  
WO/2019/086400A1
The invention relates to novel organic semiconducting compounds containing a polycydic unit, to methods for their preparation and educts or intermediates used therein, to compositions, polymer blends and formulations containing them, to ...  
WO/2019/090229A1
Organic photovoltaic cells (OPVs) and their compositions are described herein. In one or more embodiments, the acceptor with an active layer of an OPV includes is a non-fullerene acceptor. Such non-fullerene acceptors may provide improve...  
WO/2019/084323A1
Disclosed herein is a chemical delivery system having: i) a cargo compound comprising a first reactive moiety covalently bonded to a first enrichment moiety and a tethered cargo moiety, wherein the first reactive moiety is bonded to the ...  
WO/2019/080686A1
Disclosed are an entecavir intermediate, a preparation method for the intermediate and a method for preparing entecavir using the intermediate. The synthesis methods for entecavir and the intermediate thereof in the present invention hav...  
WO/2019/080016A1
Disclosed is a four-membered ring structure fuel molecule and photochemical preparation method therefor. The structure of the fuel molecule is shown as (I), wherein n=1 or 2, and R1, R2, R3, R4, R5 and R6 are independently H or -CH3 or -...  
WO/2018/026811A3
Described herein are methods employing substituted phenyl-heteroaryl-aryl compounds, and corresponding kits directed to antifungal therapy. The antifungal activity is tolerant of a wide diversity of fungal species, being effective agains...  
WO/2019/079609A1
Provided herein are novel bioavailable dual inhibitors capable of inhibiting both soluble epoxide hydrolase (sEH) and phosphodiesterase 4 (PDE4), and methods of using the same.  
WO/2019/076198A1
A fluorescent dye compound. The mother nucleus group of the compound is a fused aromatic hydrocarbon group with a triplet energy level T1 of less than 2.2 eV, the substituent group at the periphery of the mother nucleus is a large steric...  
WO/2019/075402A1
The present disclosure is directed to method of treatment for treating or ameliorating various conditions caused by radiation exposure such as RIGS, enteritis, oral mucositis, mucositis, and proctitis by the administration of a compound ...  
WO/2019/075453A1
Provided is a method of inhibiting protein kinase C zeta/protein kinase M zeta, including contacting a sample containing an isoform of protein kinase C zeta with a compound of formula: referred to as 1-naphthol-3,6,8-trisulphonic acid, o...  
WO/2019/074749A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder...  
WO/2019/074747A1
Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated dise...  
WO/2019/071104A1
The present disclosure is directed, in part, to compounds, or pharmaceutically acceptable compositions thereof, for treating and or preventing hyperammonemia. The present invention is also directed, in part, to methods of treating or pre...  
WO/2019/067272A1
A method comprising synthesizing a cyclic organic compound via reaction of an unsubstituted or substituted cyclopentene with an unsubstituted or substituted acrylic acid in the presence of phosphoric and/or sulfonic acid reagent to make ...  
WO/2019/058290A1
The present invention relates to an improved process for the preparation of optically chiral amino compound. The present invention particularly relates to the improved process for the preparation of (S)-1-amino-2,3-dihydro-1H-indene-4-ca...  
WO/2019/056128A1
Compositions comprising two or more cannabinoids, a terpene, and a flavonoid suitable for use in treating insomnia are disclosed. In preferred embodiments, the cannabinoids are cannabidiol and tetrahydrocannabinol, while the terpenes and...  
WO/2019/056129A2  
WO/2019/054450A1
Provided is a novel method for producing a compound represented by formula (I). The present invention relates to a method for producing a compound represented by formula (TH-2), and a compound represented by formula (I) via formula (TH-2...  
WO/2019/055076A1
This invention relates to processes and systems for converting acyclic hydrocarbons to alkenes, cyclic hydrocarbons and/or aromatics, for example converting acyclic C5 hydrocarbons to cyclopentadiene in a reactor system. The process incl...  
WO/2019/051038A1
Processes for making bicyclic compounds and precursors thereof, and particularly for making [1.1.1]propellane and bicyclo[1.1.1]pentane and derivatives thereof, utilize continuous flow reaction methods and conditions. A continuous proces...  
WO/2019/026004A3
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  
WO/2019/046240A1
The present invention provides compositions and methods for detecting GluAl, as a subunit protein and/or as a GluAl -containing, GluA2-lacking AMPAR complex. The invention further provides composition and methods for detecting and/or dia...  
WO/2019/046491A1
The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties o...  
WO/2019/046806A1
Disclosed herein are embodiments of a method for making cannabidiol. Also disclosed herein are embodiments of a composition comprising cannabidiol and one or more GRAS components. The method and composition embodiments described herein a...  
WO/2019/035061A1
The present disclosure relates to methods of producing enantiodefined polycyclic ring compounds. More particularly, the present disclosure provides synthetic methods of producing biologically active enantiodefined steroidal compositions ...  
WO/2019/032631A1
Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is CH or N; Y is CH or N; R1 is -OH or -OP(O)(OH)2; L1 is -CR3=N-O-CRaRa- or CRaR-O-N=CR3; L2 is a bond, -C(O)-, or S(O)2-;and R2, R3, Ra, m, and n are defined her...  
WO/2019/026004A2
The present invention provides a process of synthesizing 1-(((Z)-(1-(2-aminothiazol-4-yl)-2-oxo-2-(((3S,4R)-2-oxo-4-( (2-oxooxazolidin-3-yl)methyl)-1-sulfoazetidin-3 yl)amino)ethylidene)amino)oxy)cyclopropanecarboxylic acid (referred to ...  
WO/2019/018495A1
A polystyrene-g-(polyisobutylene-b-polystyrene) is taught. The polystyrene-g-(polyisobutylene-b-polystyrene) is synthesized by first providing a polystyrene backbone. Once the polystyrene backbone is provided, the polystyrene backbone is...  
WO/2019/018185A1
The compounds of the invention as shown by general structure I, as shown below, are effective in treating filovirus infections. Structure I X is selected from the group consisting of O and H; R1 is selected from (C6 to C10) aryl and (C2 ...  
WO/2019/011826A1
The present invention relates to a ring closure reaction useful in synthesizing fused aromatic or heteroaromatic ring systems, which may, for example, be used as organic semiconductor materials.  
WO/2019/014492A1
Disclosed herein are methods for treating cancer comprising administering CAR-modified immune cells and at least one Retinoic Acid Receptor and/or Retinoid X Receptor active agent.  
WO/2019/004021A1
The purpose of the present invention is to control the alignment of liquid crystal molecules of a liquid crystal display element not having an alignment film, by using a non-colored alignment-control-layer-forming monomer, and to provide...  
WO/2019/005273A1
Disclosed are a process for abating 3-cyclohexenone from a feed mixture comprising 3-cylclohexenone and cyclohexanone, comprising a hydrogenation step of contacting the feed mixture with hydrogen in the presence of a hydrogenation cataly...  
WO/2019/005274A1
Disclosed are processes for abating 3-cyclohexenone from a feed mixture comprising cyclohexylbenzene, cyclohexanone, phenol, and 3-cylclohexenone and cyclohexanone, comprising feeding the feed mixture to a first distillation column and a...  
WO/2019/005276A1
Disclosed are processes for making cyclohexanone from a feed mixture comprising cyclohexylbenzene, cyclohexanone, phenol, 3-cylclohexenone and optionally 2-cyclohexenone, comprising feeding the feed mixture to a first distillation column...  
WO/2018/231091A1
Field of use: the invention relates to combinatorial chemistry, pharmaceutics and cosmetology, and allows the synthesis of novel combinatorial libraries of antibiotic derivatives for use in pharmaceutics and cosmetology. Essence of the i...  
WO/2018/226976A1
The present disclosure provides compositions and methods of use to inhibit the interaction of menin with MLL1, MLL2 and MLL-fusion oncoproteins. The compositions and methods of use are useful for the treatment of leukemia, solid cancers,...  

Matches 1 - 50 out of 6,962