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WO/2022/068057A1 |
Provided is a continuous production method for 2,4-dinitrochlorobenzene. In the method, concentrated nitric acid, concentrated sulfuric acid, and chlorobenzene serve as raw materials; after a mixed acid solution is prepared, chlorobenzen...
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WO/2022/061920A1 |
A method for preparing 3',5'-dichloro-2,2,2-trifluoroacetophenone. The method comprises subjecting 3'-chloro-2,2,2-trifluoroacetophenone as a raw material to four steps, i.e. nitrification, reduction, chlorination and deamination, so as ...
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WO/2022/052683A1 |
The present invention provides a method for preparing a water-soluble magnolol derivative and a honokiol derivative, methods for preparing intermediates of a water-soluble magnolol derivative and a honokiol derivative, and a related mono...
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WO/2021/244136A1 |
Provided in the present invention is a refinement method for nitromethane. The refinement method comprises the following steps: (1) rectifying a nitromethane crude product, and collecting a gas phase fraction for condensation, thus produ...
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WO/2021/237371A1 |
The present application describes process for preparing an ortho-allylated hydroxy aryl compounds such as compounds of Formula (I) by reacting an allylic alcohol with a hydroxy aryl compound in the presence of aluminum compound selected ...
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WO/2021/219647A1 |
The present invention relates to a method for preparing paracetamol continuously, comprising a nitration step or a nitrosation step so as to obtain p-nitrophenol or p-nitrosophenol, respectively. The p-nitrophenol or p-nitrosophenol can ...
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WO/2021/214146A1 |
The invention relates to a safe and efficient process for the for the acylation of an α,ω-alkanediol, which can be used in the manufacture of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advanta...
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WO/2021/214145A1 |
The invention relates to a safe and efficient process for the nitrate ester formation of an α,ω-C3-10alkanediol monoacylate. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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WO/2021/214144A1 |
The invention relates to a safe and efficient process for the hydrolysis of α,ω-C3-10alkanediol mononitrate monoacylates. The process is safer to operators and allows to obtain advantageous yields on industrial scale.
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WO/2021/214143A1 |
The invention relates to a safe and efficient process for the solvent removal and recovery by distillation in a process for the preparation of ω-nitrooxy-C3-10alkane-1-ols. The process is safer to operators and allows to obtain advantag...
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WO/2021/208951A1 |
Disclosed is a β-diketone cerium (IV) compound of formula (I). The compound has a wide absorption band, is suitable for near ultraviolet-visible region curing as a photoinitiator, and has a high sensitiveness, while also having the adva...
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WO/2021/174748A1 |
The present invention relates to a method for preparing a visible light catalyzed dichlorine addition product of an aliphatic olefin, comprising the following steps: using an aliphatic olefin as a substrate, using copper chloride having ...
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WO/2021/160468A1 |
The present invention relates to a process for the preparation of 1-[4-nitro-2-(trifluoromethyl)- phenyl]-alkanones and substituted phenoxyphenyl ketones.
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WO/2021/127743A1 |
The present disclosure relates to substituted hydroxystilbene compounds and derivatives, specifically 2-substituted hydroxystilbene compounds and derivatives, the synthesis of such compounds and their use in therapy.
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WO/2021/116146A1 |
The present invention relates to a method for continuously operating a distillation column, which is designed to separate a mixture S, which contains essentially a substance A and a substance B, which boils significantly higher than subs...
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WO/2021/089183A1 |
The invention relates to a process (100) and to a plant for producing monoethylene glycol (110), wherein, in a carbonylation step (21), carbon monoxide (102) is reacted with methyl nitrite (104) to form dimethyl oxalate (105) and nitroge...
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WO/2021/082752A1 |
The present invention provides a preparation method for 1-nitro-2-ethyl-4-fluorobenzene. The preparation method comprises the following steps: (1) performing a nitration reaction between m-fluoroacetophenone and a nitration reagent to ob...
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WO/2021/047978A1 |
The present invention relates to a process for the preparation of α-methyl-[4-(nitro)-2- (trifluoromethyl)]-benzyl nitrate and to the α-methyl-[4-(nitro)-2-(trifluoromethyl)]-benzyl nitrate.
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WO/2021/042411A1 |
Disclosed are an AKR1C3 inhibitor or a pharmaceutically acceptable salt of same, a preparation method for same, and uses thereof. A structural optimization is performed with a nonsteroidal anti-inflammatory medicament, flurbiprofen, serv...
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WO/2021/045207A1 |
The present invention relates to a production method for a highly reactive intermediate. The production method includes: preparing an electron-accepting active compound (1); preparing a piezoelectric material (3); and applying mechanical...
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WO/2021/031431A1 |
Disclosure relates to a use of a fluorination gas, wherein the elemental fluorine is present in a high concentration, for example, in a concentration of elemental fluorine, especially of equal to much higher than 15 % or even 20% by volu...
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WO/2021/001044A1 |
Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of Eltrombopag, passing through/using intermediate 5'-Chloro-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid alkaline metal sal...
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WO/2020/248127A1 |
A borohydride reduction stabilizing system and a method for reducing an ester to an alcohol. The borohydride reduction stabilizing system comprises: a borohydride reducing agent and a stabilizing agent for stabilizing the borohydride red...
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WO/2020/248279A1 |
The present invention provides a continuous synthesis method for a substituted benzoate organic matter. The continuous synthesis method comprises: in the presence of a catalyst and an organic solvent, continuously feeding an organic matt...
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WO/2020/248278A1 |
The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represen...
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WO/2020/238862A1 |
The present invention provides a fluorene initiator, a photocurable composition comprising same, and an application thereof. The fluorene photoinitiator has a structure represented by formula (I) or formula (II). In the photoinitiator, o...
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WO/2020/230555A1 |
A method for forming a carbon-carbon bond, wherein: a reaction is performed by filling a container with a platinum group metal-loaded catalyst and having a starting material liquid permeate through the platinum group metal-loaded catalys...
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WO/2020/222041A1 |
This invention provides a novel method that is simple, efficient, and allows for a reliable production of fluorine- 18 (18F) radiofluorinated compounds and radiopharmaceuticals. The method comprises an "in-loop" process, where an 18F sou...
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WO/2020/212333A1 |
The invention relates to a continuously operating process for producing nitrobenzene, comprising the following steps: a) nitriding benzene in adiabatic conditions with sulfuric acid and nitric acid, using a stoichiometric excess of benze...
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WO/2020/212334A1 |
The invention relates to a continuously operating process for producing nitrobenzene, comprising the following steps: a) nitriding benzene in adiabatic conditions with sulfuric acid and nitric acid, using a stoichiometric excess of benze...
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WO/2020/164217A1 |
Disclosed is a process for the manufacture of fluoroaryl compounds and derivatives thereof, in particular of fluorobenzenes and derivatives thereof, and especially wherein said manufacture relates to an environmentally friendly productio...
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WO/2020/126088A1 |
The present invention refers to a co-crystal of Ketoprofen Lysine named Form 1, a pharmaceutical composition comprising said co-crystal, a process for its production and to its use in the treatment of pain and inflammatory diseases.
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WO/2020/127386A1 |
A method is provided for preparing an intermediate d having the formula: (I). The method comprising carrying out the following one-pot reaction: (II) wherein step (i) is carried out in the presence of a solvent and step (ii) is carried o...
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WO/2020/109420A1 |
The present invention relates to a novel process for the synthesis of mono- and bis-nitrosylated propanediols, as well as novel compositions and pharmaceutical formulations comprising said compounds. The process proceeds by reacting a co...
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WO/2020/103556A1 |
The present invention relates to a nitric acid reduction conversion process, the process involving bringing a raw material gas that is rich in nitric oxide into contact with a raw material liquid containing nitric acid and methanol in a ...
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WO/2020/095322A1 |
Disclosed herein is an efficacious process for preparation of highly purified Glycopyrrolate tosylate in high yield. The process is being cost effective, environment friendly and easily scalable to high volume industrial production.
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WO/2020/082194A1 |
A process for producing an alkyl nitrite is provided, comprising: mixing oxygen and a circulating gas in a pre-reactor, mixing the oxidized circulating gas and an alkyl alcohol liquid in a first esterification tower to generate alkyl nit...
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WO/2020/084094A1 |
The present invention relates to a process for preparing a nitrated compound, comprising the step of reacting a compound (A) comprising at least one substituted or unsubstituted aromatic or heteroaromatic ring, wherein said heteroaromati...
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WO/2020/079144A1 |
In a process for workup of mixed acid and wastewater from the nitration of aromatics in which the nitric acid present is converted by reaction with an aromatic under adiabatic conditions, a. at least one waste stream component selected f...
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WO/2020/053193A1 |
The invention relates to a safe and efficient process for the manufacture ω-nitrooxy-C3-10alkane-1-ols.
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WO/2020/053194A1 |
The invention relates to a process for the preparation of ω-nitroxyC3-1 0 alkane-1-ols comprising the nitration of an α,ω-C 3-10 alkanediol with a nitration agent, optionally in the presence of a nitrite trapping agent, characterized ...
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WO/2020/021323A1 |
A nitration reactor (10) incorporating sections of downward flow for use in preparing nitrated organic compounds. It comprises a first vertically-oriented reactor section (12), a second vertically-oriented reactor section (14), a connect...
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WO/2020/011626A1 |
The present invention refers to a crystalline 2-fluoro-3-nitrotoluene compound of formula (I), and a process for the preparation thereof. Furthermore, the present invention relates to a process for the synthesis of a compound of formula ...
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WO/2020/011817A1 |
The invention relates to a method for the continuous adiabatic nitration of benzene with nitric acid and sulfuric acid, the diluted sulfuric acid obtained during nitration being concentrated by flash evaporation in an evaporation device ...
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WO/2019/216415A1 |
The present disclosure addresses the problem of providing a production method for a novel fluoromethyl derivative. The problem is solved by a production method that is for a fluorinated organic compound represented by formula (1) [in the...
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WO/2019/179110A1 |
Disclosed are a catalysis test paper prepared by compounding bacterial-cellulose-supported metal particles with plant fibers, and a preparation method therefor. Hydroxyl groups of bacterial cellulose are bonded with a nitrogen- or phosph...
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WO/2019/172184A1 |
Provided is a metal imide complex which has a stable structure and is able to be easily synthesized, while being capable of efficiently oxidizing various substrates. A metal imide complex which contains a metal and an imide that serves a...
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WO/2019/168269A1 |
The present invention relates to a bifunctional chiral organocatalytic compound having excellent enantioselectivity, a preparation method therefor, and a method for producing a non-natural gamma amino acid from a nitro compound by using ...
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WO/2019/162149A1 |
The present invention relates to a process for preparing the hexanoic acid, 6-(nitrooxy)-, (1S,2E)-3-[(1R,2R,3S,5R)-2-[(2Z)-7-(ethylamino)-7-oxo-2-hept
en-1-yl]- 3,5-dihydroxycyclopentyl]-1-(2-phenylethyl)-2-propen-1-yl ester of formula ...
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WO/2019/159596A1 |
Provided is a method for preparing a coupled body represented by general formula (3), the coupled body being obtained by reacting a compound represented by general formula (1) and a compound represented by general formula (2) in the pres...
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