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JP5339040B2 |
To provide a novel anticancer drug that has an activity of inhibiting cell growth, and moreover, is effective even to a cancer cell having acquired resistance, and a novel compound suitable therefor. The novel naphthoquinone compound is ...
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JP5339041B2 |
To provide a novel anticancer drug that has an activity of inhibiting cell growth, and moreover, is effective even to a cancer cell having acquired resistance, and a novel compound suitable therefor. The novel naphthoquinone compound is ...
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JPWO2012029433A1 |
Provided are a treatment material and a treatment method for effectively treating organic compounds, viruses, microorganisms and the like. The treatment material according to the present invention is a treatment material for decomposing ...
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JP5324441B2 |
Agglomerated zeolite adsorbents comprising a barium X zeolite powder and an inert binder have a Dubinin volume of at least 0.245 cm 3>/g and a mechanical strength (Shell SMS1471-74) of at least 2 MPa. The zeolite powder has a crystal dia...
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JP5321856B2 |
An isoxazoline-substituted benzamide compound of formula (1) or a salt thereof: wherein A 1 , A 2 and A 3 independently of one another are carbon atom or nitrogen atom, G is benzene ring, etc., X is halogen atom, C 1 -C 6 haloalkyl, etc....
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JP2013538677A |
The method comprises: single-stage or multi-stage washing of crude aromatic nitro compound to give an organic phase and an aqueous phase and/or separation of the aqueous phase or the aqueous phases; optionally removing an organic compone...
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JP5315787B2 |
To develop an imidazolium salt's form which can be prepared easily and retrieved easily. The imidazolium salt is represented by formula (1) [wherein, R1, R2and R3are each independently H, a (substituted) alkyl or (substituted) aryl, wher...
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JP5313335B2 |
The present invention relates to a preparation method of carboxylic acids with optical activity, particularly, publishes that very useful chiral carboxylic acids can be obtained by the asymmetric catalytic hydrogenation of tri-substitute...
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JP5310814B2 |
To provide a method of forming a carbon-carbon bond by the Suzuki-Miyaura coupling of an aromatic boric acid ester with an aromatic compound other than the aromatic boric acid ester with the use of a solid catalyst easily separable from ...
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JP5307103B2 |
Nitroaldol ("Henry") reactions between nitroalkanes and aldehydes in the presence of a catalyst and a two-phase reaction medium produce nitroalcohols at increased reaction rates compared to single-phase organic solvent systems, and do no...
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JP5299974B2 |
Disclosed is a technology for enabling an efficient asymmetric Michael addition reaction which does not require a large amount of a malonic ester, while having a short reaction time. Specifically disclosed is a catalyst which is composed...
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JP2013184077A |
To provide a paramagnetic gas adsorbing material which can adsorb a paramagnetic gas of the amount larger than before and which has excellent adsorbing property.A paramagnetic gas adsorbing material comprises a metal complex comprising: ...
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JP2013184947A |
To provide a method capable of manufacturing a biaryl compound from an aryl chloride compound that is low in reactivity, in the presence of a small amount of a catalyst and under a mild condition.A method for manufacturing a biaryl compo...
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JP5295613B2 |
To provide a method for producing an iodinated aromatic compound having high positional selectivity and suited to an industrial production. The present method for producing an iodinated aromatic compound comprises reacting an aromatic co...
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JP5295560B2 |
Compounds of the formula (I): in which R, R1 and R2 are as defined in the description, the use thereof for the treatment of dyslipidaemia, atherosclerosis and diabetes, pharmaceutical compositions comprising them, and . processes for the...
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JP5292778B2 |
To provide a new optical film further suppressing wavelength dependence of a phase difference value and a new compound for providing the film. The compound, for example, represented by formula (J-3) is exemplified.
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JP2013535478A |
The present invention relates to a continuous process for the production of nitrobenzene by nitration of benzene with nitric acid or mixtures of nitric acid and sulfuric acid to give a crude nitrobenzene, washing of the crude nitrobenzen...
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JP5284286B2 |
Disclosed herein are novel platinum-based analogs possessing two nitrile substituent groups (bis-nitrile) covalently-bonded to the platinum. Also disclosed herein are the reaction schemes for the synthesis of said platinum complexes, as ...
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JP2013173751A |
To provide a method for preparing alkenylnitrobenzenes important as an intermediate for alkylanilines having bactericidal activity with improved selectivity, and high purity and yield.A method for preparing a nitrobenzene derivative repr...
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JP5281152B2 |
A 2-alkyl-3-aminothiophene derivative represented by general formula (4) can be produced by a production process comprising the following steps: oxidizing a compound represented by general formula (1) to produce a compound represented by...
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JP5279508B2 |
The invention relates to the salts of styphnic acid, to methods for producing the same and to their use.
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JP5279077B2 |
It is intended to provide a method of rapid methylation of an aromatic compound or an alkenyl compound, which is capable of obtaining an aromatic compound or an alkenyl compound labeled with a methyl group or a fluoromethyl group under a...
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JP2013533219A |
A carbocatalyst for use in oxidation and polymerization reactions includes particles having a carbon and oxygen-containing material, such as catalytically-active graphene oxide and/or catalytically-active graphite oxide. In some cases, t...
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JP5266194B2 |
Disclosed is a novel process and novel intermediates to prepare [R-(R*,R*)]-N-[3-[1-[5,6-dihydro-4-hydroxy-2-oxo-6-(2-phenyl
ethyl)-6-propyl-2H-pyran-3-yl]propyl]phenyl]-5-(trifluoromet
hyl)-2-pyridinesulfonamide (XIX) which is a proteas...
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JP5266055B2 |
The invention relates to a fungicidally active compound of formula (I): as defined in claim 1; to the preparation of these compounds, to novel intermediates used in the preparation of these compounds, to agrochemical compositions which c...
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JP5262642B2 |
To provide a method for forming a carbon-carbon bond by Stille coupling, by subjecting an organic compound having a leaving group and an organotin compound to wet Stille coupling, not requiring additives except the organic compound havin...
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JP5265123B2 |
Disclosed are a catalyst including a hydrotalcite and, immobilized on a surface thereof, particles of at least one metal selected from the group consisting of Cu, Ag, and Au; a method for producing a carbonyl compound through dehydrogena...
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JP5261181B2 |
The present invention relates to 2,5-di-substituted-4-phenyloxy-substituted-phenyl-amidine derivatives of formula (I) in which the substituents are as in the description, their process of preparation, their use as fungicide or insecticid...
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JP5263754B2 |
To provide a method for efficiently producing a cyclic ketone (aromatic ring-condesed cycloalkenone), which can be utilized as agrochemicals, their production intermediates and the like. The cyclic ketone expressed by general formula (II...
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JP5258856B2 |
To provide a novel electron transport substance which, as compared with a conventional electron transport substance, has more excellent organic solvent solubility and film-forming properties and more excellent electron transport capacity...
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JP5255561B2 |
The invention provides 3,3′-diamino-5,5′-diphenyl-4,4′-biphenyldiol which is useful as a monomer for a high-performance polymer, particularly a polymer satisfying performances highly required in the semiconductor field such as poly...
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JP5250997B2 |
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JP5252614B2 |
The invention is directed to nonpeptide substituted benzazepines of Formula I, which are useful as vasopressin receptor antagonists for treating conditions associated with vasopressin receptor activity such as those involving increased v...
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JP5248489B2 |
Disclosed is a method for producing a halogenated aromatic compound, which is characterized in that an aromatic compound wherein one or more substituents and two or more hydrogen atoms are attached to a nucleus and an N-iodine bond type ...
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JP5243303B2 |
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JP2013529594A |
The present invention provides stereoselective processes for the preparation of compounds of formula (I) wherein P is phenyl, naphthyl, a 6-membered heteroaryl group containing one or two nitrogen atoms as ring members, or a 10-membered ...
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JP5237798B2 |
Provided are processes for the preparation of benzimidazole structures having Formula VIIIb-1: and salts and solvates thereof, wherein Z, X5, R2b, R2c and R10 are as defined herein. Compounds of Formula VIIIb-1 are useful for the prepara...
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JP5237797B2 |
Provided are methods for the synthesis of heterocyclic compounds such as benzimidazole carboxylic acid core structures having Formula Ia-2 and their synthetic intermediates: wherein X1, X2, X5, R1, R2 and R4 are as defined herein. Compou...
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JP5234901B2 |
A process for producing a product of the asymmetric-catalyst Michael reaction. By the process, an a,ß-unsaturated aldehyde can be reacted with a nitroalkane such as nitromethane to obtain the corresponding Michael addition product in a ...
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JP5234633B2 |
The present invention relates to anhydrous solutions of MX 3 ¢z LiA in a solvent, wherein M is a lanthanide including lanthanum, or yttrium or indium; z > 0; and X and A are independently or both monovalent anions, preferably Cl, Br o...
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JP5225078B2 |
The present invention provides an efficient, safe and cost effective way to prepare 5-(4-methyl-1 H -imidazol-1-yl)-3-(trifluoromethyl)-benzenamine which is a key intermediate for the preparation of substituted pyrimidinylaminobenzamides...
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JPWO2011105521A1 |
To provide a metal complex having excellent gas adsorption performance, gas storage performance and gas separation performance. The following general formula (I); [Chemical 1] (In the formula, R1~ R4Is as described in the specification. ...
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JP2013522273A |
A process for preparing [(1 R ,2 R )-4-oxo-1,2-cyclopentanedicarboxylic acid II, by the resolution of racemic 4-oxo-1,2-cyclopentanedicarboxylic acid (V), said process comprising: (a) reacting 4-oxo-1,2-cyclopentanedicarboxylic acid (V) ...
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JP5209324B2 |
The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim 1, by a) reaction of a compound of formula (II) to form a compound of formula (III) b) reaction o...
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JPWO2011093461A1 |
The present invention provides a method for controlling the activity of a physiologically active substance, which can be universally used for a wide variety of physiologically active substances. The physiologically active substance is in...
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JP5197439B2 |
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JP2013516422A |
The present invention relates to enzyme inhibitors. More specifically, the present invention relates to ligand-directed covalent modification of proteins; method of designing same; pharmaceutical formulation of same; and method of use.
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JP5193664B2 |
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JP5193861B2 |
The present invention relates to biaryl carboxylic acid compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing these compounds and methods of treating diseases which express the Mcl-1 protein.
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JP2013514300A |
A process for working up alkaline process wastewater from the nitration of aromatic compounds to mono-, di- and trinitroaromatics with a pH of 7.5 to 13 or a mixture W with a pH of 6 to 10 of alkaline process wastewater and the aqueous d...
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