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JP5742126B2 |
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JP5727127B2 |
The present invention provides an organic metal compound, a ligand, an asymmetric catalyst, and a process for preparing optically-active alcohols using the asymmetric catalyst. The organic metal compound of the present invention is expre...
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JP5725299B2 |
1,4 naphthoquinones derivatives, of formula (I) wherein A is selected from the following rings: their preparation and their application as antimalarial agents
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JP5712481B2 |
Disclosed is a method for producing a compound having a difluoromethylene group at an even lower cost and with excellent yield. The production method of the present invention is a method for producing an aromatic difluoroacetic acid este...
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JP5711263B2 |
Disclosed is an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. The apparatus may be designed such that it can synthesize more than one nitroalkane using the same equipment.
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JP2015512887A |
A process of preparing a nitro alcohol, such as 2-nitro-2-methyl-1-propane, from a nitro polyol, such as 2-nitro-2-methyl-1,3-propanediol, under hydrogenation conditions. A process involving contacting a nitro polyol with hydrogen, a hyd...
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JP2015071547A |
To provide a production method of a difluoromethylene compound.The production method of a difluoromethylene compound represented by formula (IIIa) id provided in which difluoro acetate represented by formula (Ia) is reacted with an aryl ...
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JP5700624B2 |
To provide a catalyst for cross coupling dramatically improved in catalyst activity compared with a conventional catalyst, capable of making best use of a metal surface on a catalyst efficiently in a cross coupling reaction by using tran...
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JP5698128B2 |
It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via nitro group-containing ether compound of the formula (1). (wherein R 1 , R 2 and R 6 ar...
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JP5698249B2 |
Provided is a process for making nitrated hydrocarbons by reacting aqueous nitric acid with a hydrocarbon feedstock and a carboxylic acid under specific reaction conditions.
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JP5696355B2 |
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JP5698129B2 |
It is possible to produce oseltamivir safely and stably in large quantities by using as a starting material tartaric acid, mannitol or arabinose, via nitro group-containing ether compound of the formula (1). (wherein R 1 , R 2 and R 6 ar...
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JP5698229B2 |
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JP5689111B2 |
A catalytic Wittig method utilizing a phosphine including the steps of providing a phosphine oxide precatalyst and reducing the phosphine oxide precatalyst to produce the phosphine; forming a phosphonium ylide precursor from the phosphin...
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JP2015048333A |
To provide a method for producing a nitrating agent not necessarily requiring the use of a large quantity of acid, and a method for producing a nitro compound.Provided is a nitrating agent including: an inorganic porous member; and a nit...
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JP5684585B2 |
The present invention relates to compounds which directly inhibit IRE-1± activity, and which are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
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JP5683761B1 |
An object of the present invention is to provide an optically active bicyclic γ-amino acid derivative with high purity. The solution is to produce a mixture of compounds having the general formula (I) and the general formula (I'), or a ...
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JP5675737B2 |
The invention relates to a fungicidally active compound of formula (I): as defined in claim 1; to the preparation of these compounds, to novel intermediates used in the preparation of these compounds, to agrochemical compositions which c...
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JP5673124B2 |
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JP2015504857A |
The present invention relates to an improved additive composition that controls and inhibits the polymerization of aromatic vinyl monomers such as styrene. In one embodiment, the invention also relates to a method of using the compositio...
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JP5663482B2 |
Provided is a process by which pyrimidinylacetonitrile derivatives can be prepared easily and efficiently from industrially available raw materials. Also provided are intermediates for the synthesis of the derivatives. A process for the ...
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JP2015502391A |
The present invention in cosmetic compositions intended for anti-aging and / or depigmenting and / or anti-inflammatory and / or curative care products, the following formula I: (where n and m are equal to 0 or 1 , Where n + m = 1, R1 an...
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JP5654686B2 |
Disclosed is a method of making a 2-substituted-1,4-benzenediamine by nucleophilic aromatic substitution.
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JP5649480B2 |
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JP5648054B2 |
The disclosure provides methods for the use of open metal frameworks to catalyze coupling reactions.
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JP2014240429A |
To provide activated fatty acids, pharmaceutical compositions including activated fatty acids, methods for using activated fatty acids to treat a variety of diseases, and methods for preparing activated fatty acids.This invention provide...
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JP5645537B2 |
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JP5642422B2 |
3-(2-Alkylthio-5-acylphenyl)-isoxazoles (I) are prepared by a multi-stage process via 3-(2-aminophenyl)-isoxazole intermediates (VI). Also new are various oxime and isoxazole derivative intermediates, including (VI); and methods for prep...
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JP5638953B2 |
The invention relates to a process for making HOF.RCN and using it to oxidise organic substrates in a quick and safe way. The process comprises passing diluted fluorine through a conduit and RCN in water through another conduit into a mi...
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JP5639199B2 |
The present invention relates to the preparation of highly efficient chiral heterogeneous catalyst for asymmetric nitroaldol reaction, wherein Henry reactions of various aldehydes such as aromatic, aliphatic, alpha,beta-unsaturated aldeh...
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JP2014224130A |
To provide novel, herbicidally active cyclic diones, and derivatives thereof, processes for their preparation, compositions comprising those compounds, and their use in controlling weeds, especially weeds in crops of useful plants, or in...
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JP5635992B2 |
An improved process for the preparation of p-nitrobenzyl bromide from p-nitrotoluene is disclosed wherein large excess of the reactant in carbon tetrachloride is treated with 2:1 bromide-bromate reagent and the product is isolated effici...
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JP5635275B2 |
To provide a method for oxidizing an alcohol, which efficiently produces an aldehyde or ketone using molecular oxygen without using a metal catalyst. The method for oxidizing an alcohol includes oxidizing an alcohol in the presence of an...
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JP2014530810A |
Provided in the present invention are geranylgeranylacetone derivatives and methods using them.
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JP5620504B2 |
Disclosed are a process and apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. Energy and capital costs may be reduced by using a dividing wall column.
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JP5602143B2 |
A method for making mononitrobenzene using a plug flow reactor train. Benzene, nitric acid and sulfuric acid are introduced into the reactor and produced mononitrobenzene is removed at an outlet end. All of the benzene and at least part ...
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JP5603487B2 |
This invention is directed to a process for the preparation of high yield alkyl or aryl iodide from its corresponding carboxylic acid using N-iodo amides.
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JP2014185149A |
To provide a biaryl phosphodiesterase-4 (PDE4) inhibitor useful for treatment and prevention of stroke, myocardial infarction, cardiovascular inflammatory diseases and central nervous system disorders.There is provided a biaryl compound ...
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JP2014525393A |
The present invention is the method of refining the crude aromatic nitro compounds originating in nitration of aromatic compounds, The following washing processes (a), (a) Crude aromatic nitro compound (N*in), it includes performing the ...
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JP5595047B2 |
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JP5587200B2 |
The invention relates to a method for carrying out a chemical reaction for producing a target compound by heating in a reactor a reaction medium containing at least one first reactant, such that a chemical bond inside the first reactant ...
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JP5584233B2 |
Compounds of Formula (I), wherein the substituents are as defined in claim 1, are suitable for use as herbicides.
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JP2014148477A |
To provide a reaction method in which a further easy-to-use oxidation-reduction condensation reaction can be realized.When a stereospecific reaction by activation of an alcoholic hydroxy group is performed under the presence of an azo co...
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JP5574669B2 |
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JP5575668B2 |
The invention provides a process for preparing bronopol, which process comprises charging a reaction vessel with water, bromopicrin, nitromethane and paraformaldehyde, gradually feeding a base into said reaction vessel under stirring, br...
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JP5570509B2 |
Provided are a complex prepared from ammonium salt-containing ligands and having such an equilibrium structural formula that the metal center takes a negative charge of 2 or higher, and a method for preparing polycarbonate via copolymeri...
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JP5566878B2 |
The present invention provides several methods for the preparation of novel aryl pyrrolidines of fomula (I), and intermediates for the preparation of such pyrrolidines having an excellent insecticidal action as insecticides. Aryl pyrroli...
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JP5567477B2 |
Disclosed are a process suited to large scale synthesis with high yield for producing oseltamivir phosphate, in which a preparation of oseltamivir phosphate which is highly safe as a pharmaceutical product can be produced, and an interme...
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JP5563663B2 |
Disclosed are a process and an apparatus for synthesizing nitroalkanes by reaction of a hydrocarbon feedstock with aqueous nitric acid. By using an isothermal reactor with multiple input ports for aqueous nitric acid, a hydrocarbon feeds...
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JP5561732B2 |
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