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Matches 1 - 50 out of 20,037

Document Document Title
WO/2018/069833A1
The present invention relates to stable amorphous form of sacubitril valsartan trisodium complex and its solid dispersion compounds, processes for their preparation and pharmaceutical composition comprising the same. The present inventio...  
WO/2018/070303A1
Provided is a resist underlayer film-forming composition which is capable of providing a resist underlayer film, said resist underlayer film exerting a sufficient anti-reflection function particularly in a KrF process, a high solvent res...  
WO/2018/068295A1
Substituted aryl and heteroaryl ether compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R 1, R 2, R 3, L, R 4, L 1, Q, and R 5 are as defined herein. These compounds and pharmaceutically acceptable co...  
WO/2018/068937A1
The invention relates to a method for producing carboxamides of formula (1) by reacting at least one alkyl phenyl carboxylic acid of formula (2) with at least one secondary amine of formula (3), where R1 represents an alkyl group having ...  
WO/2018/065415A1
The present invention relates to a rheology modifier and to its use as thickener in oil-based subterranean treatment fluids; more particularly, the rheology modifier is an aqueous slurry of a pyromellitamide.  
WO/2018/060413A1
The present invention relates to a procatalystcomprising the compound represented by formula Aas an internal electron donor (Formula A), wherein R is hydrogen or a methyl group, N is nitrogen atom; O is oxygen atom; and C is carbon atom....  
WO/2018/062663A1
Provided are: a compound represented by a particular chemical formula; a core-shell dye including a core, which includes the compound, and a shell, which surrounds the core; a photosensitive resin composition including same; and a color ...  
WO/2018/056546A1
Provided are: a compound represented by a particular chemical formula; a core shell dye which comprises a core comprising the compound, and a shell covering the core; a photosensitive resin composition comprising the core-shell dye; and ...  
WO/2018/052936A1
Provided herein are therapeutic acrylate compounds useful as medical adhesives, comprising a therapeutic agent covalently linked to a methacrylate or cyanoacrylate moiety. Adhesive compositions and kits, such as liquid sutures and bone c...  
WO/2018/051042A1
The invention relates to a method for the industrial synthesis of the compound of formula (I).  
WO/2018/052037A1
The present invention addresses the problem of providing a novel branched fluorine-containing compound. The problem is solved by a branched fluorine-containing compound represented by formula (1): [in the formula, L represents a predeter...  
WO/2018/045505A1
Provided are new crystalline forms A, B, C, D, and E of sacubitril sodium salt and a method for preparation thereof, pharmaceutical compositions thereof, and application thereof in preparing drugs for enkephalinase-related diseases.  
WO/2018/041615A1
Processes and systems for producing N-vinyl carboxylic acid amides are provided herein. According to some aspects of the present invention, a process for producing an N-vinyl carboxylic acid amide is described that eliminates interim sol...  
WO/2018/043829A1
Provided are a compound represented by a specific formula, a core-shell dye comprising a core comprising the compound and a shell enclosing the core, a photosensitive resin composition comprising the core-shell dye, and a color filter ma...  
WO/2018/038436A1
The present invention provides a novel diamine compound capable of producing a polymer which exhibits greatly enhanced mechanical properties and heat resistance while maintaining transparency. A film including a polymer produced using th...  
WO/2018/033525A1
This invention relates to compounds that are agonists or partial agonists of the histamine site of the NMDA receptor, the method of preparation thereof and applications thereof.  
WO/2018/030533A1
Provided are: a method for producing an N-(α-alkoxyethyl)formamide, which comprises mixing N-(α-hydroxyethyl)formamide with an alcohol and then adding an acid catalyst within 3 hours after the starting of the mixing, and which makes it...  
WO/2018/029347A1
1. Synthesis of bitter principle derivatives based on the denatonium structure according to formula (1). 2.1. The aim of the invention is to introduce couplable carboxylic acid functionalities into the denatonium structure by means of si...  
WO/2018/025429A1
Provided is a simple method for producing perfluoroalkyl compounds that serve as important intermediates for organic electronic materials, pharmaceuticals, agricultural chemicals, polymer functional materials, etc., the method involving ...  
WO/2018/018863A1
Disclosed are a mild and efficient preparation method for an α-acyloxy alkenyl amide compound and a use thereof in the synthesis of an amide and a polypeptide. The α-acyloxy alkenyl amide compound is obtained by an addition reaction of...  
WO/2018/019867A1
The present invention relates to a compound of general formula (I). The present invention also relates to a method of producing N-acetyl homoserine and/or derivatives thereof, the method comprising contacting at least one recombinant cel...  
WO/2018/018851A1
A preparation method for oseltamivir carboxylic acid hydrochloride comprises the following steps: a, introducing protective groups A to amidos of oseltamivir phosphate 1, so as to obtain a compound 2; b, hydrolyzing ester groups on the c...  
WO/2018/019774A1
The present invention provides a hole-transporting or hole-injecting material for an optoelectronic device, comprising a compound of the formula (I) and/or a compound of the formula (II), (I) (II) wherein: Ar1 and Ar2 independently repre...  
WO/2018/018113A1
The present invention relates to methods for producing spilanthol and spilanthol analogues, as well as the resultant spilanthol 1 and analogues thereof. Spilanthol and spilanthol analogues according to the present invention exhibit high ...  
WO/2018/018091A1
The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of pulmonary fibrosis and/or related conditions.  
WO/2018/016376A1
The present disclosure provides a reaction of a chlorine-containing compound with use of a flow reactor that has few limits on a solvent to be used therein. According to the present disclosure, a chlorine-containing compound and a reacti...  
WO/2018/017954A1
The present invention relates to antimicrobial cationic systems and methods of use thereof.  
WO/2018/014111A1
There is provided methods, compositions and treatment regimens for treating cancer, or for inhibiting metastasis/recurrence of cancer in a patient using 1) a primary cancer treatment such as chemotherapy, and 2) within 12 to 120 hours po...  
WO/2018/011230A1
The present invention relates to new peroxisome proliferator-activated receptor gamma (PPARϒ) agonists, and their uses as in the prevention and/or treatment of type 2 diabetes, impaired glucose tolerance, insulin resistance syndrome, hy...  
WO/2018/010932A1
The present invention relates to a method of reacting starting materials with an activating group, namely alkanes carrying a leaving group and/or olefins, with carbon dioxide under transition metal catalysis to give carboxyl group-contai...  
WO/2018/001680A1
The invention relates to a method in which an amino acid is, in the presence of an amine, reacted with an acyl group donor to obtain an N-acyl amino acid.  
WO/2018/001148A1
Provided is a method for preparing a pregabalin intermediate 3-isobutylglutaric acid monoamide. The method comprises: 1) adding 3-isobutylglutaric acid and urea into a first organic solvent; 2) keeping warm and refluxing when heated to 1...  
WO/2018/003652A1
A compound used in the conventional enzymatic reactions and mass spectrometry methods needs to be altered with respect to the structure thereof as a substrate compound, such as the length of an alkyl chain contained therein, depending on...  
WO/2017/222930A1
Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formul...  
WO/2017/215586A1
Provided are amide derivatives, a preparation process thereof and a use thereof in medicine. More specifically, provided are amide derivatives represented by the general formula (I) or pharmaceutically acceptable salts thereof, a process...  
WO/2017/203474A1
The present application relates to a process for preparation of tert-butyl (R)-(1-([1,1'-biphenyl]-4- yl)-3-hydroxypropan-2-yl)carbamate (IA). The compound of formula (IA) may be used as an intermediate for the preparation of sacubitril.  
WO/2017/202273A1
Disclosed in the present invention are a benzyl phenyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to a benzyl phenyl ether derivative re...  
WO/2017/197637A1
Methods of treating inflammation conditions in a subject is provided, including administering to the subject an effective amount of one or more caffeic acid derivatives to effectively alter the polarization of macrophages from M1 to M2, ...  
WO/2017/192844A1
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...  
WO/2017/192304A1
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...  
WO/2017/191332A3
A process of forming compounds of formula (I) comprising the steps of addition of an amino compound H2NR to a compound of formula (II) followed by cyclization, isomerization and hydrolysis.  
WO/2017/192840A1
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...  
WO/2017/191620A1
The present invention provides a process for the preparation of a salt of sacubitril. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril. The present invention further provides a cry...  
WO/2017/190299A1
A method for recovering a DMAC or DMF waste liquid using seven-tower five-effect rectification. The waste liquid comprising DMAC or DMF is entered into a DMAC or DMF finished product tank after being successively processed via a preheate...  
WO/2017/193063A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2017/181811A1
Disclosed are an opctahydroanthracene compound as represented by formula (I) or (II), a preparation method for same, and uses of same, which provides great therapeutic effects for tumors and neurodegenerative diseases and is prepared mai...  
WO/2017/184115A1
Compositions and methods of using of such compositions to, for example, inhibit of the formation of gas hydrate agglomerates are provided. In one embodiment, the methods comprise: introducing hydrate inhibitor composition comprising a co...  
WO/2017/184113A1
Compositions and methods of using of such compositions to, for example, inhibit of the formation of gas hydrate agglomerates are provided. In one embodiment, the methods comprise: introducing a hydrate inhibitor composition comprising a ...  
WO/2017/177919A1
Provided in the present invention is a compound as shown in formula (I), formula (II) or formula (III). The compound is capable of inhibiting the binding of the PB2 protein of the influenza virus to an RNA cap, and has a function of oppo...  
WO/2017/177979A1
Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being desc...  

Matches 1 - 50 out of 20,037