Login| Sign Up| Help| Contact|

Patent Searching and Data


Matches 1 - 50 out of 19,969

Document Document Title
WO/2018/011230A1
The present invention relates to new peroxisome proliferator-activated receptor gamma (PPARϒ) agonists, and their uses as in the prevention and/or treatment of type 2 diabetes, impaired glucose tolerance, insulin resistance syndrome, hy...  
WO/2018/010932A1
The present invention relates to a method of reacting starting materials with an activating group, namely alkanes carrying a leaving group and/or olefins, with carbon dioxide under transition metal catalysis to give carboxyl group-contai...  
WO/2018/001680A1
The invention relates to a method in which an amino acid is, in the presence of an amine, reacted with an acyl group donor to obtain an N-acyl amino acid.  
WO/2018/001148A1
Provided is a method for preparing a pregabalin intermediate 3-isobutylglutaric acid monoamide. The method comprises: 1) adding 3-isobutylglutaric acid and urea into a first organic solvent; 2) keeping warm and refluxing when heated to 1...  
WO/2018/003652A1
A compound used in the conventional enzymatic reactions and mass spectrometry methods needs to be altered with respect to the structure thereof as a substrate compound, such as the length of an alkyl chain contained therein, depending on...  
WO/2017/222930A1
Certain compounds of formula I: I and salts including pharmaceutically acceptable salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formul...  
WO/2017/215586A1
Provided are amide derivatives, a preparation process thereof and a use thereof in medicine. More specifically, provided are amide derivatives represented by the general formula (I) or pharmaceutically acceptable salts thereof, a process...  
WO/2017/203474A1
The present application relates to a process for preparation of tert-butyl (R)-(1-([1,1'-biphenyl]-4- yl)-3-hydroxypropan-2-yl)carbamate (IA). The compound of formula (IA) may be used as an intermediate for the preparation of sacubitril.  
WO/2017/202273A1
Disclosed in the present invention are a benzyl phenyl ether derivative, a preparation method therefor, and a pharmaceutical composition and uses thereof. Specifically, the present invention relates to a benzyl phenyl ether derivative re...  
WO/2017/197637A1
Methods of treating inflammation conditions in a subject is provided, including administering to the subject an effective amount of one or more caffeic acid derivatives to effectively alter the polarization of macrophages from M1 to M2, ...  
WO/2017/192844A1
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...  
WO/2017/192304A1
The present disclosure is directed to compounds of formula (I): or a pharmaceutically acceptable salt, solvate or solvate of the salt thereof. Compounds of formula (I) are inhibitors of NOX4 and are useful in the treatment of fibrotic di...  
WO/2017/191332A3
A process of forming compounds of formula (I) comprising the steps of addition of an amino compound H2NR to a compound of formula (II) followed by cyclization, isomerization and hydrolysis.  
WO/2017/192840A1
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, vi...  
WO/2017/191620A1
The present invention provides a process for the preparation of a salt of sacubitril. Specifically, the present invention provides a process for the preparation of a sodium salt of sacubitril. The present invention further provides a cry...  
WO/2017/190299A1
A method for recovering a DMAC or DMF waste liquid using seven-tower five-effect rectification. The waste liquid comprising DMAC or DMF is entered into a DMAC or DMF finished product tank after being successively processed via a preheate...  
WO/2017/193063A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2017/181811A1
Disclosed are an opctahydroanthracene compound as represented by formula (I) or (II), a preparation method for same, and uses of same, which provides great therapeutic effects for tumors and neurodegenerative diseases and is prepared mai...  
WO/2017/184115A1
Compositions and methods of using of such compositions to, for example, inhibit of the formation of gas hydrate agglomerates are provided. In one embodiment, the methods comprise: introducing hydrate inhibitor composition comprising a co...  
WO/2017/184113A1
Compositions and methods of using of such compositions to, for example, inhibit of the formation of gas hydrate agglomerates are provided. In one embodiment, the methods comprise: introducing a hydrate inhibitor composition comprising a ...  
WO/2017/177919A1
Provided in the present invention is a compound as shown in formula (I), formula (II) or formula (III). The compound is capable of inhibiting the binding of the PB2 protein of the influenza virus to an RNA cap, and has a function of oppo...  
WO/2017/177979A1
Provided are a heterocyclic carboxylic acid amide ligand and applications thereof in a copper catalyzed coupling reaction. Specifically, provided are uses of a compound represented by formula (I), definitions of radical groups being desc...  
WO/2017/177781A1
The present invention relates to AHU377 crystal forms, and a preparation method therefor and the use thereof. Provided are AHU377 crystal forms III and IV, and the crystal forms III and IV have a good stability, a low hygroscopicity, a h...  
WO/2017/174615A1
The present invention is directed to N-alkyldiamide compounds responding to the following formula (I), wherein: R1 or R2 is selected from hydrogen or a linear, branched or cyclic, saturated or unsaturated, hydrocarbon chain having from 1...  
WO/2017/169445A1
Disclosed are: a heavy atom compound which makes it possible to perform the determination of a phase of a crystal of a membrane protein easily without deteriorating the quality of the crystal and also makes it possible to analyze the str...  
WO/2017/172476A1
Compounds, compositions, and methods for the treatment of Canavan disease are described.  
WO/2017/166914A1
The present invention relates to a preparation method of a three-arm atom transfer radical polymerization (ATRP) initiator with a planar-conjugated structure. First, 1,3,5-tris(4-aminophenyl)benzene is reacted in a nucleophilic substitut...  
WO/2017/170044A1
Provided is an acrylic polymer composition containing an acrylic polymer and a polyfunctional organic compound represented by general formula (1). (In the general formula (1), R1 and R2 each independently represent a hydrogen atom or a C...  
WO/2017/172606A1
The present invention provides a therapy for treating loss of GABA-mediated pre-synaptic inhibition after spinal injury. The therapeutic regimen includes spinal segment-specific upregulation of GAD65 (glutamate decarboxylase) and VGAT (v...  
WO/2017/160156A1
The invention relates to synthetic capasaicin analogs as TRPV1 agonists and uses thereof for prophylactic and therapeutic use.  
WO/2017/160922A1
Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.  
WO/2017/159656A1
The present invention provides a composition, specifically a cosmetic composition, containing (A) at least one compound or salt thereof selected from the group consisting of compounds represented by formula (1-1) and salts thereof and co...  
WO/2017/152755A1
The present invention provides a substituted biphenyl compound and a pharmaceutical composition thereof, the substituted biphenyl compound being a compound represented by formula (I), or a crystal form, a pharmaceutically acceptable salt...  
WO/2017/153235A1
The invention relates to novel substituted N-cyclo-3-aryl-1-naphthamide derivatives, to methods for producing same, to the use thereof, either alone or in combination, for the treatment and/or prevention of diseases, and to their use for...  
WO/2017/156354A1
The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure : Formula (I)  
WO/2017/153950A1
The 4-hydroxyphenyl-2-oxoethyl carboxylic derivatives of the general formula: R1-A- R2, wherein the core A is: Formula (I) and R1 is phenyl substituted with two C1-C4 alkyl, 1,3-benzodioxolyl or bicyclo[3.3.1]nonanyl and R2 is H, hydroxy...  
WO/2017/155288A1
The present invention relates to a polyethylene glycol derivative and use thereof.  
WO/2017/148357A1
The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate can be prepared by subjecting a compound to a deprotection reaction. The intermediate can be used as a raw material ...  
WO/2017/147646A1
The invention relates to a dual emission fluorescent compound comprising a chromophore suitable for exhibiting an emission at a first wavelength from an excited state; wherein the compound further comprises one or more groups suitable fo...  
WO/2017/150904A1
The present invention relates to a pharmaceutical composition for treating or preventing CNS disorders containing a carbamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the p...  
WO/2017/145569A1
Provided is a method for producing an N-vinyl carboxylic acid amide, the method focusing on unsaturated aldehydes that are contained as impurities generated during a reaction. The method for producing an N-vinyl carboxylic acid amide is ...  
WO/2017/145022A1
Described herein are UV-absorbing vinylic monomers conjugated to 2-aminobenzophenone derivatives and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and violet radiation with waveleng...  
WO/2017/145024A1
Described herein are water-soluble UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ("UV") radiation and optionally (but preferably) violet radiation with wavelengths ...  
WO/2017/143438A1
The present document describes a pharmaceutical excipient composition comprising a functionalized anionic polysaccharide having carboxyl groups complexed with an amino acid-divalent cation complex, monolithic solid dosage forms for dual ...  
WO/2017/141512A1
Provided is a catalyst represented by general formula (1), where R1-R16 in the general formula (1) individually represent a hydrogen atom or a substituent independently of each other.  
WO/2017/141911A1
The present invention relates to (2E)-N-[2-(dimethylamino)ethyl]-2-hexadecenamide, 2-(diethylamino)ethyl (2E)-2-hexadecenoate, or pharmaceutically acceptable salts thereof. In addition to activating signal transmission via the MAP kinase...  
WO/2017/141193A1
The present invention provides processes for the preparation of sacubitril or salts thereof. The present invention further provides intermediates of Formula IV, V and VI and their use for the preparation of sacubitril or salts thereof.  
WO/2017/137895A1
The subject-matter of the present invention relates to the synthesis of new dendrimeric molecules based on polyhydroxylated pyrrolidines obtained by means of Click Chemistry reactions. The proposed molecules inhibit the enzymes N-acetylg...  
WO/2017/131097A1
Provided is a pharmaceutical composition for the treatment or prevention of a cognitive disease or disorder, the composition comprising a compound represented by formula (1), an enantiomer thereof or diasteriomer thereof, or a pharmaceut...  
WO/2017/131500A1
The present invention relates to: a novel compound having an HSP90 inhibitory activity or a pharmaceutically acceptable salt thereof; and a medical use thereof. A composition, of the present invention, containing a dihydroxyphenyl-based ...  

Matches 1 - 50 out of 19,969