Acyclic or Carbocyclic Compounds

Matches 201 - 250 out of 1,376	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
WO/2003/016306A1	HIV INHIBITING PYRIMIDINES DERIVATIVES This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing -a?1¿=a?2...
WO/2003/011210A2	ARYLHETEROALKYLAMINE DERIVATIVES AND THEIR USE AS INHIBITORS OF NITRIC OXIDE SYNTHASE There are provided novel compounds of formula (I), wherein R1, R2, R3, T, U, X, Y, V and W are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes...
WO/2003/008393A1	METHOD FOR PRODUCING LAMOTRIGINE FROM ALPHA-OXO-2,3-DICHLOROPHENYL ACETAMIDINO-AMINOGUANIDINO HYDRAZONE BY RING CLOSURE REACTION The invention relates to a method for producing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) by ring closure reaction from $g(a)-oxo-2,3-dichlorophenyl acetamidino-aminoguanidino hydrazone.
WO/2003/006444A2	SUBSTITUTED AMIDES, SULFONAMIDES AND UREAS USEFUL FOR INHIBITING KINASE ACTIVITY Amide, sulfonamide and urea compounds having an inhibitory effect on Src kinase including enantiomers, stereoisomers and tautomers thereof, as well as pharmaceutically acceptable salts or solvates of said compound, said compound having t...
WO/2003/000653A1	SUBSTITUTED N-ACYL ANILINE DERIVATIVES, PRODUCTION AND USE THEREOF AS MEDICAMENTS The invention relates to novel substituted N-acyl aniline derivatives of general formula (I), where R?1¿ to R?5¿, A, X, Y and Z are as defined in claim 1, the tautomers, stereoisomers, mixtures, prodrugs, derivatives with a group, nega...
WO/2002/091989A2	ANTIVIRAL THERAPIES USING POLYAMINE OR POLYAMINE ANALOG-AMINO ACID CONJUGATES Methods for treating viral diseases are provided, using conjugates in which polyamine analogs are conjugated to an amino acid.
WO/2002/083630A1	OXALIC ACID DERIVATIVES Novel compounds of the formula (I) in which R?1¿, R?2¿, R?3¿, R?4¿, X and Z are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders ...
WO/2002/083030A2	BIFUNCTIONAL ENERGY-REVERSIBLE ACYL-COMPOSITIONS Energy-reversible acyl conjugates, intermediates, and related compositions are disclosed. In preferred aspects, examples of such compositions include Formulae (A) and (B).
WO/2002/079145A1	BENZAMIDE INHIBITORS OF FACTOR Xa Novel benzamide compounds of formula (I), their salts and compositions related thereto having activity against mammalian Factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorde...
WO/2002/076395A2	AGENTS AND METHODS FOR TREATMENT OF CANCER Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase ...
WO/2002/070468A2	NOVEL BENZAMIDINE DERIVATIVES HAVING ANTI-INFLAMMATORY AND IMMUNOSUPPRESSIVE ACTIVITY Compounds which can be represented by the general formula (I) and in which A is selected independently from the carboxamide group, the thiocarboxamide group, and the carbonyl group, -R¿1? is selected from an alkyl group having from 1 to...
WO/2002/070471A1	PHENYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF THROMBOEMBOLIC DISORDERS OR TUMOURS Compounds of the formula (I) in which R?1¿ is CN, or C(=NH)-NH¿2?, CON(R?3¿)¿2? or [C(R?4¿)¿2?]¿n?N(R?3¿)¿2?, each of which is unsubstituted or monosubstituted by C(=O)R?3¿, COOR?3¿, or?3¿ or by a conventional amino-protectin...
WO/2002/066418A2	PROCESS FOR THE PREPARATION OF ARYLETHANOLDIAMINES USEFUL AS AGONISTS OF THE BETA-3-ADRENOCEPTOR An improved process for preparing arylethanoldiamines is described. Compounds of this type are known to be useful as agonists at atypical beta-adrenoceptors (also known as beta-3-adrenoceptors).
WO/2002/064136A2	MALONYL-COA DECARBOXYLASE INHIBITORS USEFUL AS METABOLIC MODULATORS The present invention relates to novel compounds (I), their prodrugs, and the pharmaceutically acceptable salts as well as pharmaceutical compositions containing such compounds useful in treating certain metabolic diseases and diseases m...
WO/2002/062766A2	MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF MC4-R binding compounds of the formula: B-Z-E (I) wherein B is an anchor moiety, Z is a central moiety, and E is a MC4-R interacting moiety are discussed. Methods of using the compounds to treat MC4-R associated disorders, such as disord...
WO/2002/062778A2	ANTI-THROMBOTIC COMPOUNDS, PRODUCTION AND USE THEREOF AS MEDICAMENTS The invention relates to anti-thrombotic compounds of general formula (I), where R¿1? to R¿4?, Ar, A, m and n are as defined in claim 1, the tautomers, stereoisomers, mixtures, pro-drugs and salts thereof which have worthwhile properti...
WO/2002/060861A1	BENZAMIDINE DERIVATIVES AND PROCESS FOR PRODUCTION THEREOF A process for the production of amidine derivatives represented by the general formula (II) or salts thereof, characterized by reducing an amidoxime derivative represented by the general formula (I) with zinc in an acetic acid solvent: (...
WO/2002/058690A2	METHODS FOR THE TREATMENT OF DISEASES USING MALONYL-COA DECARBOX YLASE INHIBITORS The present invention relates to methods for the prophylaxis, management and treatment of certain diseases modulated by the inhibition of the enzyme malonyl-coenzyme A decarboxylase (malonyl-CoA decarboxylase, MCD) by the administration ...
WO/2002/057236A1	PHENYL DERIVATIVES Novel compounds of the formula I in which W, X, Y, T, R?1¿ and R2 are as defined in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic disorders.
WO/2002/042273A2	ACID DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS Compounds having the formula (I), are useful as serine protease inhibitors, more particularly inhibitors of Factors VIIa, Ixa, Xa, and/or Xia, wherein ring B is phenyl or pyridyl, W is preferably C(=O)NR¿4?R¿5?, L is a linker group, X�...
WO/2002/042248A2	NAPHTHALENE DERIVATIVES The present invention relates to naphthalene derivatives of formula (I), wherein X is S, S(O), S(O)¿2?, S(O)¿2?NH, P(O)OCH¿3?, P(O)OH, NH, N(CH¿3?), NHC(O)NH, C(O), C(O)O, NHC(O), CH(OH), CH=N, CH=CH, CH¿2?NH, C(=NH); R?1¿ is aryl ...
WO/2002/038105A2	NOVEL POLYAMINE ANALOG-AMINO ACID CONJUGATES USEFUL AS ANTICANCER AGENTS Conjugates in which polyamine analogs are conjugated to an amino acid are provided, as well as compositions comprising these conjugates. Methods of using these conjugates as anticancer treatments are also provided.
WO/2002/037937A2	ACID DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS Compounds of formula I and II, or pharmaceutically-acceptable salts thereof , are useful as inhibitors of Factor VIIa, Factor IXa, Factor Xa, Factor FXIa, tryptase, and urokinase, wherein ring B is phenyl or pyridyl, L is a linker, and R...
WO/2002/038553A2	TRIAZOLE DERIVATIVES AND THEIR USE AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONISTS he present invention is directed to compounds represented by the following structural formula (I'), and pharmaceutically acceptable salts, solvates and hydrates thereof, R1 is a substituted or unsubstituted group selected from C¿1?-C¿8...
WO/2002/034711A1	BIARYL COMPOUNDS AS SERINE PROTEASE INHIBITORS Compounds of formula (I) are useful as inhibitors of trypsin like serine protease enzymes such as thrombin, factor VIIa, factor Xa, TF/FVIIa, and trypsin. These compounds could be useful to treat and/or prevent clotting disorders, and as...
WO/2002/028823A1	MALONAMID AND MALONAMIC ESTER DERIVATIVES WITH ANTITHROMBOTIC ACTIVITY, THEIR PREPARATION AND THEIR USE The present invention relates to compounds of formula (I), in which R1, R1, A and B have the meanings indicated in the claims. The compounds of formula (I) are valuable pharmacologically active compounds. They exhibit a strong antithromb...
WO/2002/022561A1	2-AMINO-2-ALKYL-3 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention relates to 2-amino-2-alkyl-3 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
WO/2002/022562A1	2-AMINO-2-ALKYL-5 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention relates to 2-amino-2-alkyl-5 heptenoic and heptynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
WO/2002/022559A2	2-AMINO-2-ALKYL-4 HEXENOIC AND HEXYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
WO/2002/022553A2	NON-NATURAL BASIC AMINO ACIDS, THEIR PREPARATION AND USE This invention relates to positively charged non-natural amino acids, methods of making thereof, and utilization thereof in peptides.
WO/2002/022558A2	2-AMINO-2-ALKYL-3 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention relates to 2-amino-2-alkyl-3 heptenoic and heptynoic as derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
WO/2002/022557A2	2-AMINO-2-ALKYL-4 HEPTENOIC AND HEPTYNOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention relates to 2-amino-2-alkyl-4 heptenoic and heptynoic ac derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
WO/2002/022694A1	CATALYSTS CONTAINING PER-ORTHO ARYL SUBSTITUTED ARYL OR HETEROARYL SUBSTITUTED NITROGEN DONORS Catalyst compositions useful for the polymerization of olefins are disclosed. These compositions comprise a Group 8-10 metal complex comprising a bidentate or variable denticity ligand comprising two nitrogen donor atoms independently su...
WO/2002/020526A2	CYCLIC AND ACYCLIC AMIDINES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR USE AS PROGESTERONE RECEPTOR BINDING AGENTS Disclosed are cyclic and acyclic amidines, pharmaceutical compositions containing such amidines, and their use in treating or preventing progesterone receptor mediated diseases or conditions, such as osteopenia and osteoporosis.
WO/2002/010127A1	ACETAMIDE DERIVATIVES AND THE USE THEREOF AS INHIBITORS OF COAGULATION FACTORS XA AND VIIA The invention relates to novel compounds of formula (I) wherein R, R?1¿ and R?2¿ have the designation cited in patent claim 1. Said compounds are inhibitors of the coagulation factors Xa and VIIa, and can be used to treat thromboses, m...
WO/2002/002516A2	INHIBITORS OF HIV INTEGRASE The present invention is a series of novel and effective inhibitors of integrase, an essential in the life cycle of retroviruses. These compounds were designed to have a restricted conformation for the determination of the integrase bind...
WO/2001/098262A1	AMIDINE DERIVATIVES AS SELECTIVE ANTAGONISTS OF NMDA RECEPTORS A class of styryl amidine derivatives which are antagonists of the hum NMDA receptor, being selective for those containing the NR2B subunit, are active in the treatment and/or prevention of neurological and neurodegenerative disorders, i...
WO/2001/096366A2	DIPEPTIDE INHIBITORS FOR THE BLOOD-CLOTTING FACTOR XA The invention relates to derivatives of amidino-benzylamine, especially derivatives of 4-amidino-benzylamine, with two bonded amino acids. These derivatives represent a novel group of highly active and very selective F Xa-inhibitors for ...
WO/2001/094333A2	PROCESS FOR THE PREPARATION OF BENZOYL SUBSTITUTED BICYCLIC COMPOUNDS AND CHIRAL BENZOPYRAN DERIVATIVES Disclosed are processes for coupling amino substituted 2-chromanyl derivatives and benzoyl derivatives via an amide bond, and intermediates for producing platelet aggregation inhibitors and for producing potent platelet aggregation inhib...
WO/2001/092207A1	PROCESS FOR THE PRODUCTION OF NITROGEN COMPOUNDS A process of reacting a compound having an NH group with a thiocyanate, a cyanamide, a nitrile, or an ester in the presence of a silylating agent to thereby obtain the corresponding nitrogen-containing addition or substitution product. T...
WO/2001/090051A1	PHENYLGLYCINE DERIVATIVES The invention is concerned with novel N-(4-carbamimidoyl-phenyl)-glycine derivatives of the formula (I) wherein X and R?1¿ to R?5¿ are as defined in the description and in the claims, as well as hydrates or solvates and/or physiologica...
WO/2001/085674A1	PROCESS FOR THE PREPARATION OF PYRAZINE COMPOUNDS The present invention relates to a process for the preparation of both the phenyl pyrazine derivative 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine and an intermediate in the synthesis of 2,6-diamino-3-(2,3,5-trichlorophenyl)pyrazine, 2-...
WO/2001/083571A2	CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS Catalyst compositions useful for the polymerization or oligomerization of olefins are disclosed. Certain of the catalyst compositions comprise N-pyrrolyl substituted nitrogen donors. Also disclosed are processes for the polymerization or...
WO/2001/079156A1	HALOGENATED 2-AMINO-4, 5 HEPTENOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention contains halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
WO/2001/078719A1	HALOGENTATED 2-AMINO-5,6 HEPTENOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
WO/2001/078654A2	HALOGENTATED 2-AMINO-3, 4 HEPTENOIC ACID DERIVATIVES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS The present invention contains halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
WO/2001/079155A2	POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED 1,4-QUINONES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE The invention relates to polycyclic aryl and heteroaryl substituted 1,4-quinone compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treat...
WO/2001/070678A2	SUBSTITUTED BIPHENYL DERIVATIVES The invention relates to compounds of general formula (I) where R?1¿ = -C(=NH)NH¿2 ?optionally substituted with COA, -CO-, [C(R?7¿)¿2?]¿n?-Ar', -COOA, OR?7¿, OCOA, OCO-[C(R?7¿)¿2?]¿n?-Ar', -OH or by a conventional amino protecti...
WO/2001/068605A1	POLYCYCLIC ARYL AND HETEROARYL SUBSTITUTED BENZENES USEFUL FOR SELECTIVE INHIBITION OF THE COAGULATION CASCADE The invention relates to polycyclic aryl and heteroaryl substituted benzene compounds useful as inhibitors of serine proteases of the coagulation cascade and compounds, compositions and methods for anticoagulant therapy for the treatment...
WO/2001/068585A1	NOVEL AMIDE COMPOUNDS A compound represented by the general formula (I) and a salt thereof: R?1¿-A-X-NHCO-Y-R?2¿ wherein R?1¿ is an optionally substituted heterocyclic group or optionally substituted phenyl; R?2¿ is optionally substituted fused phenyl, op...

Matches 201 - 250 out of 1,376	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >