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WO/2013/045431A1 |
The present invention is directed to novel retinoid-related orphan receptor gamma (RORy) modulators of formula (I), processes for their preparation, pharmaceutical compositions containing these modulators, and their use in the treatment ...
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WO/2013/039985A2 |
Potent low molecular weight, highly selective, competitive non-peptidic serine protease inhibitors and their use in treating serine protease-associated diseases are disclosed.
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WO/2013/030803A1 |
6-chloro-3-[2-(1-ethyl-propylamino)-3,4-dioxo-cyclobut-1-eny
lamino]-2-hydroxy-N- methoxy-N-methyl-benzenesulfonamide choline, solid pharmaceutical compositions and oral dosage forms that contain said compound, and a method of using such...
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WO/2013/033046A2 |
UV-Absorbing and fluorescent pl markers for isoelectric focusing separations and fluorescent labeling, and methods for making and using the markers.
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WO/2013/026942A1 |
The invention provides combretastatin A-4 like compounds that are modified to have enhanced tubulin binding activity and in some embodiments the ability to promote accumulation in the vasculature undergoing angiogenesis (homing activity)...
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WO/2013/021309A1 |
The invention relates to a crystalline form of 2-chloro-N-{2-[3-(2-{[(4'-hydroxybiphenyl-3- yl)methyl]amino}-2-oxoethyl)phenyl]-1,1-dimethylethyl}acetam
ide, a process for preparing the same and its use in the preparation of the 2 ago...
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WO/2012/137982A9 |
Provided is a compound having an AMPA receptor function enhancing action, and useful as a prophylactic or therapeutic drug for depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like. ...
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WO/2013/019091A2 |
Disclosed are a novel compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the same for inhibiting human 11-β-hydroxy steroid dehydrogenase type 1 (11β-HSD1). The disclosed compound and t...
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WO/2013/017469A1 |
Described herein are novel solid-supported sulfurization reagents having the general structure: (I) wherein (P) is a polymer; X is a linker; R1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and R2 is an alkyl gr...
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WO/2013/011485A1 |
The present invention relates to a process for the preparation of sulfonamides useful as retroviral protease inhibitors.
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WO/2013/008700A1 |
An actinic ray-sensitive or radiation-sensitive resin composition, includes: (A) a compound represented by the following formula (I); and (B) a resin: wherein X represents an oxygen atom, a sulfur atom or -N(Rx)-; each of R1 to R8 and Rx...
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WO/2013/004871A1 |
The invention relates to a compound having formula (I) or a stereoisomer, a salt or a solvate, in which: A is -CH(OH)- or -C(=0)-; Z is H or OH; n is 0 or 1; R1 is alkyl(C1-C30), alkenyl(C2-C30) or alkynyl(C2-C30); B is -H, -N3 or -CΞCH...
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WO/2013/005828A1 |
A purpose of the present invention is to provide an additive for nonaqueous electrolytes which has excellent storage stability and which, when used in electricity storage devices such as a nonaqueous-electrolyte secondary battery and an ...
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WO/2013/005045A1 |
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activi...
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WO/2013/002660A2 |
The present invention relates to a process for preparing (R)-5-(2-(benzylamino)ethyl)-1-(6,8-difluorochroman-3-yl)-1H
-imidazole-2(3H)-thione, and pharmaceutically acceptable salts thereof, especially the hydrochloride salt. The inventio...
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WO/2013/000315A1 |
A guaiazulene derivative, a preparation method and a use thereof. The compound is highly stable and is applicable in treating gastric ulcer. [Formula I]
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WO/2012/175654A1 |
Tetraline sulfonamides derivatives highly specific towards CA IX and/or CA XII human carbonic anhydrase for targeting solid tumors.
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WO/2012/174926A1 |
The present invention provides an N-substituted isopropyldimethyl azulene sulfonamide derivative as represented by formula (1), and preparation method and uses thereof. R1 is an alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, amin...
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WO/2012/171484A1 |
Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum fungicidal activity in the field of agricultu...
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WO/2012/168162A1 |
Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing ...
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WO/2012/163815A1 |
The invention relates to the preparation of chiral compounds, in particular to the preparation of chiral compounds which may be used as intermediates for the preparation of anti-diabetic agents, preferably sitagliptin.
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WO/2012/165314A1 |
The present invention provides an amide compound useful as a therapeutic agent for hypertension and the like. The present invention provides a compound represented by general formula (I) [wherein R1: an optionally substituted adamantyl g...
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WO/2012/163799A1 |
The present invention relates to a novel enantioselective method of preparing (S)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6-5 methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonami
de, to novel inte...
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WO/2012/165648A1 |
The present invention provides a compound having an excellent efficacy for controlling weeds. A cyclohexanone compound of the formula (I): wherein m is an integer of 1, 2 or 3; n is an integer of any one of 1 to 5; X represents CH2, O, S...
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WO/2012/160112A1 |
The iodine compounds of the present invention corresponds to those of formula (I), wherein R1, R1' and X have several meanings. These iodine compounds gives rise to the amination of several substrates without the need of catalysts, espec...
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WO/2012/160034A1 |
The present invention relates to 4-aryl-N-phenyl-1,3,5-triazin-2-amines containing a sulfoximine group of general formula (I) or (Ia) as described and defined herein, and methods for their preparation, their use for the treatment and/or ...
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WO/2012/154728A1 |
The present invention provides a compound of Formula (I), as defined herein, or a pharmaceutically acceptable salt thereof.
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WO/2012/147944A1 |
The present invention provides a method for producing a compound represented by general formula (1) (wherein R1, R2, R3, R10-R14, A1-A3, n1 and n2 are as defined in the description), which is characterized by reacting a compound represen...
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WO/2012/142698A1 |
Compounds of formula (I) : wherein A, m, n, R1, X, Y, R2, R3, R4, R5 and R6, as defined herein are provided as useful for the treatment of cancer or for the manufacture of anti-cancer agents.
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WO/2012/137813A1 |
Provided is a method for producing a bis(perfluoroalkanesulfone)imide salt by adding water and an alkali metal hydroxide to a salt containing the bis(perfluoroalkanesulfone)imide salt represented by the general formula (RfSO2)2NM (in the...
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WO/2012/133871A1 |
A polymerizable monomer is provided which is represented by the following formula (1): wherein R1 represents a hydrogen atom or an alkyl group; A represents -CO- or -SO2-; and the moiety represented by the formula (1) is, at the part sho...
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WO/2012/133881A1 |
To provide a polymeric compound having superior charge-providing properties, the polymeric compound contains at least one unit represented by the following general formula (5). General formula (5) In the general formula (5), R1 represent...
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WO/2012/047907A9 |
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among man...
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WO/2012/127173A1 |
The invention relates to a process for synthesizing benzofuran derivatives, in particular dronedarone of formula (D), comprising a step of Friedel-Crafts acylation starting from a sulfonamido-benzofuran ester intermediate.
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WO/2012/121248A1 |
A method for highly enantio-selectively producing an optically active spirolactone compound using a iodoarene derivative which can be easily synthesized and scarcely racemized. From 2,6-dihydroxyiodoarene, a flexibly designable hypervale...
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WO/2012/117961A1 |
Obtain a compound [II] such as N, N-di(fluorosulfonyl)imide ammonium salt by reacting a compound [I] such as N, N-di(chlorosulfonyl)imide and NH4F(HF)p. Obtain a compound [IV] such as N, N-di(fluorosulfonyl)imide alkali metal salt by rea...
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WO/2012/108284A1 |
A compound [I] such as an N-(chlorosulfonyl)-N-(fluorosulfonyl)imide ammonium salt is reacted with hydrogen fluoride to produce a compound [II] such as an N,N-di(fluorosulfonyl)imide ammonium salt. The resulting compound [II] is reacted ...
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WO/2012/104742A1 |
A photovoltaic element (110) is proposed for conversion of electromagnetic radiation to electrical energy, more particularly a dye solar cell (112). The photovoltaic element (110) has at least one first electrode (116), at least one n-se...
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WO/2012/101648A1 |
Where R is C1-C3 alkyl, alkenyl A novel process for synthesis of compound of Formula 1 comprising steroselective catalytic reduction of compound of Formula IV under hydrogen gas pressure to obtain an intermediate compound of Formula II, ...
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WO/2012/099184A1 |
A fluoroamine can be produced by: protecting an amino group of an amino alcohol with a nitrobenzenesulfonyl group, thereby converting into a protected amino alcohol (amino group protection step); causing the protected amino alcohol to re...
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WO/2012/082633A1 |
The present invention relates to novel bis-sulfonamide derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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WO/2012/082566A1 |
The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.
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WO/2012/069419A1 |
Compounds of general formula (I), their use as calcium receptor-active compounds for the prophylaxis, treatment or amelioration of physiological disorders or diseases associated with disturbances of CaSR activity, such as hyperparathyroi...
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WO/2012/055031A1 |
Compounds of Formula I are disclosed wherein R1, R2, R3A, R3B, R4A, R4B, R5A, R5B, R6A, R6B, R7, R8 and R9 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds...
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WO/2012/055034A1 |
Compounds of Formula I are disclosed: wherein L, A, R1, R2, R3A, R3B, R4A, R4B, R5, R6 and R7 are defined herein. The compounds encompassed by Formula I include compounds which are HIV protease inhibitors and other compounds which can be...
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WO/2012/053565A1 |
Provided is a novel process for producing an optically active β-amino aldehyde compound from an imine compound. The present invention provides a process for producing an optically active β-amino aldehyde compound (3), which comprises a...
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WO/2012/047926A2 |
This invention relates generally to the discovery of sulfonamide-containing compounds that are inhibitors of ϒ-secretase.
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WO/2012/039025A1 |
This process for producing a perfluoroalkylsulfonamide is characterized by reacting a perfluoroalkylsulfonyl halide or a perfluoroalkylsulfonic anhydride with ammonia water to obtain a liquid reaction mixture containing the ammonium salt...
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WO/2012/035171A2 |
A compound of formula (I), wherein A is S, O or a double bond, and L is a substituted thiazolyl, phenyl or pyridyl. The compound is useful for the treatment of inflammation and cancer.
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WO/2012/031993A1 |
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The present invention is also directed to processe...
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