Heterocyclic Compounds

Matches 751 - 800 out of 2,235	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >

Document	Document Title
JP7260643B2	Methods for purifying compounds that generate acids upon exposure to actinic rays or radiation, methods for producing actinic ray- or radiation-sensitive resin compositions, methods for forming patterns, and methods for producing electronic devices The present invention provides a method for purifying a compound that generates an acid when irradiated with active light or radiation, said method being capable of reducing the content of metal impurities, while having excellent recover...
JP7258763B2	Farnesoid X receptor agonists and uses thereof Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...
JP7254298B2	organic optical material Provided is a novel donor-acceptor type compound which emits light even in a solid state. The present invention provides an organic optical material comprising a complex formed from (1) a conjugated molecule having (a) at least one elect...
JP2023046675A	AMINE COMPOUND, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND PATTERN FORMING METHOD To provide a chemically amplified resist composition which exhibits high sensitivity and improved LWR and CDU regardless of whether it is positive or negative, and a pattern forming method using the same.There are provided: an amine comp...
JP2023512786A	NAMPT modulator Provided are compounds of formula (II): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of formu...
JP2023036512A	PRODUCTION METHOD OF 4-BROMOISOTHIAZOLINONE DERIVATIVE AND 4-BROMOISOTHIAZOLINONE DERIVATIVE To provide a method for selectively producing a high-purity 4-bromoisothiazolinone derivative at a good yield.Provided is a method for producing a 4-bromoisothiazolinone derivative represented by formula (1) (in which R is a hydrogen ato...
JP2023508930A	TRPML modulator The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using them. [Selection figure] None
JP7221277B2	Hepatitis B antiviral agent The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof:X-A-Y-L-R (I)which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function ...
JP2023501306A	Benzothiophene derivative regulators, their preparation and use Nitrogen-containing ring derivative regulators, methods for their preparation and uses thereof. In particular, the present invention relates to compounds represented by general formula (I), processes for their preparation, or pharmaceuti...
JP2022554330A	SSAO inhibitors and their uses A compound of formula (I') or (I), a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of SSAO, Pharmaceutical compositions comprising (I') or compounds of (I) an...
JP2022552185A	oral complement factor D inhibitor Disclosed are compounds of formula (I), and pharmaceutically acceptable salts thereof, that are inhibitors of the complement system. Pharmaceutical compositions containing such compounds and methods of using the compounds and composition...
JP7179028B2	Method for producing 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide The present invention relates to a novel process for preparing and isolating 3,4-dichloro-N-(2-cyanophenyl)-5-isothiazolecarboxamide (Isotianil), which can be used as an active compound with microbicidal properties, wherein the amount of...
JP7164542B2	A novel chemical compound, a YAP/TAZ-TEAD interaction inhibitor, and its use in the treatment of malignant mesothelioma These compounds are useful as inhibitors of the YAP/TAZ-TEAD interaction.
JP2022163087A	SMYD INHIBITORS To provide carboxamide and sulfonamide compounds as SMYD protein inhibitors, and therapeutic methods of treating conditions and diseases where inhibition of SMYD proteins provides benefit.The invention provides compounds represented by t...
JP7160486B2	biocide compound The present invention relates to the compounds of formula (I), and the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein the variables are defined according to the description,The comp...
JP7158500B2	Sulfinylaminobenzamide and sulfonylaminobenzamide derivatives Provided is a compound of Formula (I):wherein the variable groups are defined herein.
JP2022536419A	Amino acid transport inhibitor and use thereof These compounds are glutamine transporter inhibitors, eg, alanine, serine, cysteine preferred transporter 2 (ASCT2) inhibitors. Glutamine transporter inhibitors are useful for treating a variety of diseases, disorders, or conditions, inc...
JP7104232B2	Aromatic sulfonamide derivative Process for the synthesis of substituted aromatic sulfonamides of formula (Ia)comprising a deprotection reaction, an acylation/peptide coupling reaction or a Suzuki coupling reaction
JP2022530623A	Inhibition of USP36 The present disclosure relates to compounds of formulas (I)-(VI) useful as modulators of USP36. The compound is further useful in the treatment of USP36 inhibition and diseases or disorders associated with USP36 inhibition. For example, ...
JP2022527294A	Compounds and compositions as regulators of TLR signaling The present disclosure relates to therapeutic methods or agents in inflammatory diseases and specific neuropathy associated with inflammatory signaling processes including, but not limited to, compounds, pharmaceutical compositions conta...
JP2022525186A	TEAD Transcription Factor New Small Molecule Inhibitor The compounds of the present disclosure, as well as their compositions and methods of use. The compound inhibits the activity of the TEAD transcription factor and is useful in the treatment of diseases associated with the activity of the...
JP7065081B2	Bicyclic compounds useful as GPR120 modulators Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.
JP2022068394A	ONIUM SALT, CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS To provide a chemically amplified resist composition that has improved lithography performance factors such as CDU, LWR and DOF and reduced defects in photolithography using high-energy radiation as the energy source, an acid diffusion i...
JP2022065101A	COMPOUNDS CONTAINING SULFONIC GROUP AS KAT INHIBITORS To provide compounds containing a sulfonic group as KAT inhibitors.The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.SELECTED DRAWING: None
JP2022517466A	Carbon monoxide prodrug for the treatment of medical disorders The present invention provides novel compounds and compositions thereof that release carbon monoxide for the treatment of carbon monoxide-reactive medical disorders, such as inflammation, pain, and dermatological disorders. [Selection di...
JP2022507879A	Compound In the present invention, the formula (Ia) (in the formula, the XY group is -NHSO2-Or-SO2NH-is; R1Is H or alkyl; R2Is selected from COOH and tetrazolyl groups; R3Is selected from H, Cl and alkyl; R4Is selected from H, Cl and F; R5H, alky...
JP2022506898A	Compounds and compositions for treating conditions associated with NLRP activity In one embodiment, a compound of formula AA, or a pharmaceutically acceptable salt thereof, characterized by or pharmaceutically acceptable salt thereof. The variables shown in Formula A are as defined in the claims. [Chemical 1]
JP2022505626A	N-nitrosaccharins In the present invention, the general formula (I) (in the formula, R is hydrogen (H) or nitro group (NO).2) N-nitrosaccharin, its preparation, and its use as a nitroating agent.
JP2022505439A	Urea derivatives to treat and / or prevent cancer The present invention relates to cancers, particularly myeloma, head and neck cancer, and cancers that overexpress CXCR1 and CXCR2 receptors such as kidney cancer, such as myeloma, head and neck cancer, kidney cancer. And a pharmaceutica...
JP2021536458A	Aryl Hydrocarbon Receptor Antagonists and Usage The present invention relates to aryl hydrocarbon receptor antagonists, as well as methods of regulating aryl hydrocarbon receptor activity, and methods of growing hematopoietic stem cells by culturing hematopoietic stem cells or progeni...
JP6963599B2	GPR40-agonists and GPR120-sulfonamides as agonists The invention relates to compounds acting as agonists of G-protein coupled receptor 120 (GPR120) and/or 40 (GPR40), and having formula (I): Said compounds are useful in the treatment of diseases or disorders modulated by GPR120 and/or GP...
JP6950872B2	Ketone or oxime compounds, and herbicides There is provided novel agricultural chemicals, in particular herbicides. A ketone or oxime compound or a salt thereof of Formula (1):wherein B is a ring of any one of B-1, B-2, or B-3, Q is an oxygen atom, a sulfur atom, NOR7, etc., R6 ...
JP2021527126A	SARM1 inhibitor The present disclosure provides compounds and methods useful for inhibiting SARM1 and / or treating and / or preventing axonal degeneration. The provided SARM1 inhibitor reduces or inhibits the binding of NAD + by SARM1, as well as bindi...
JP2021138718A	MODULATORS OF INTEGRATED STRESS PATHWAY To provide compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases, disorders and conditions.The present disclosure provides a compound of Formula (I) or a pharmac...
JP2021134205A	METHOD FOR PRODUCING FLUORINE-CONTAINING COMPOUND To provide a method for efficient hydro-perfluoroalkylation of olefins.The present disclosure provides a method for producing a fluorine-containing compound represented by general formula (6), the method including the step of causing a r...
JP2021520354A	Method for producing 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazole carboxamide The present invention is a novel method for preparing and isolating 3,4-dichloro-N- (2-cyanophenyl) -5-isothiazolecarboxamide (isothiazole), which has bactericidal and plant-enhancing (host defense inducer) properties. Regarding the step...
JP6915911B2	Amide compounds as agents for the treatment and prevention of diseases and complications caused by RNA and / or DNA-containing viruses, and their use The present invention relates to medicine and is concerned with a compound of formula (a) below or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising an effective amount of the compound of formula (a) or a...
JP6905530B2	Farnesoid X receptor agonist and its use Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of condi...
JP2021515787A	Amide compounds of amino-benzoisothiazole and amino-benzoisothiazole Amide compounds of amino-benzoisothiazole and benzoisothiazole are provided herein. In particular, compounds that affect the function of intracellular kinases and serve as therapeutic agents or with therapeutic agents are provided herein...
JP6880166B2	Sultam compounds and how to use them Provided are a sultam compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity as represented by formula I or pharmaceutically-acceptable salts, solvates or hydrates thereof, a preparation method thereof, and a pharmaceutica...
JP2021501786A	Modulator of integrated stress pathway Provided herein are compounds, compositions, and methods useful for the regulation of integrated stress response (ISR) and the treatment of related diseases, disorders, and diseases. [Selection diagram] None
JP6790040B2	Novel compounds and compositions for inhibiting FASN The present invention relates to a list of specific 2-hydroxy-1-{4-[(4-phenylphenyl)carbonyl]piperazin-1-yl}etha n-1-one derivatives and related compounds as fatty acid synthase (FAS or FASN) inhibitors for treating cancer and pharmacuti...
JP2020183405A	COMPOSITIONS FOR TREATING AND/OR PREVENTING CELL AND/OR TISSUE NECROSIS SPECIFICALLY TARGETING CATHEPSIN C AND/OR CELA1 AND/OR CELA3A AND/OR ENZYMES STRUCTURALLY RELATED TO THEM To provide inhibitor compounds of cathepsin C, CELA1, CELA3A and/or enzymes structurally related to them, and compositions comprising the compounds for treatment of cell and/or tissue necrosis.The present invention provides compounds wit...
JP6782540B2	Resist composition, resist pattern forming method and compound To provide a resist composition, a method for forming a resist pattern, and a compound.The resist composition generates an acid by exposure and exhibits changes in the solubility with a developer by an action of an acid, and comprises an...
JP2020524718A	Heterocyclic small molecule regulator of human STING The present invention relates to compounds of formula (I). The compound can be used to regulate STING (Stimulator of Interferon Genes) proteins, thereby treating diseases such as cancer and microbial infections.
JP6738830B2	Inhibitor of human immunodeficiency virus replication Compounds of Formula I, including pharmaceutically acceptable salts thereof, and compositions and methods for treating human immunodeficiency virus (HIV) infection are set forth: (I)
JP2020520373A	Formimide amidine compounds useful against phytopathogenic microorganisms The present invention relates to 4-substituted amidine derivatives of general formula (I), where A1-A4, D, L, Q, R7, R7'and the integers v and w have the meanings as defined herein. The present invention further relates to methods for th...
JP6713928B2	URAT1 inhibitor Provided are a compound represented by the following Formula (III), a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt or solvate thereof used as a therapeutic agent for gout or hyperuricemia. (In the Formu...
JP2020094009A	AMMONIUM SALT HAVING SACCHARIN ANION To provide an ammonium salt that does not contain a halogen atom and excellent heat stability.An ammonium salt has a saccharin anion represented by formula (1) (where R-Rindependently represent a C1-4 alkyl group or an alkoxyalkyl group ...
JP2020090520A	SMYD INHIBITORS To provide compounds that are SMYD protein inhibitors, such as SMYD3 and SMYD2 inhibitors, as drugs for treating cancer in a mammal.For example, the compounds are N-(1-(1-((S)-2-aminopropanoyl)piperidin-4-yl)ethyl)-6-chloro -2-oxoindolin...

Matches 751 - 800 out of 2,235	< 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 >