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JP2020045326A |
To provide a novel compound, an agrochemical, especially a herbicide containing the compound.There is provided a ketone or oxime compound represented by the formula (1) and a herbicide containing them. [B is a substituent having a cyclop...
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JP6635269B2 |
There is provided novel agricultural chemicals, in particular herbicides. A ketone or oxime compound or a salt thereof of Formula (1):wherein B is a ring of any one of B-1, B-2, or B-3, Q is an oxygen atom, a sulfur atom, NOR7, etc., R6 ...
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JP2020500207A |
Small molecule calpain modulator compositions, pharmaceutical compositions, their use and preparation are disclosed herein.
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JP6600319B2 |
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerati...
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JP6594351B2 |
wherein, R1 and R2 are individually selected from hydrogen, alkyl, substituted or alkyl; n=0, 1, or 2; Y=NR3R4, OR5, or SR5, where R3 and R4 are individually selected from acyl or sulfonyl, and where R5 is aryl or heteroaryl, or heterocy...
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JP6552061B2 |
Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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JP6532436B2 |
To provide a composition for a battery electrode whose viscosity is stable for a long period and to provide a battery excellent in battery characteristics by obtaining an electrode whose binding strength is stably excellent.The electrode...
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JP6484233B2 |
The present invention relates to isothiazoline compounds substituted with a carbobicyclic group of formula (I) wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling inve...
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JP6461102B2 |
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JP6454413B2 |
Disclosed are an aminosulfonyl compound represented by general formula I or a tautomer, enantiomer, racemate or pharmaceutically acceptable salt thereof, a preparation method therefor, a pharmaceutical composition and a use thereof. The ...
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JP6452688B2 |
The present invention provides new stable crystalline N -iodoamides - 1-iodo-3,5,5-trimethylhydantoin (1-ITMH) and 3-iodo-4,4-dimethyl-2-oxazolidinone (IDMO). The present invention further provides a process for the preparation of organi...
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JP2018203749A |
To provide compositions for treatment and prevention of diseases caused by RNA- or DNA-containing viruses, and concomitant diseases.A pharmaceutical composition comprises a compound having the structure in the figure or a pharmaceuticall...
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JP2018199710A |
To provide novel compounds having a neprilysin inhibition activity.The invention relates to compounds represented by the formula (I) and pharmaceutical compositions containing the compounds [Rand R-Rindependently represent H or the like;...
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JP6415983B2 |
The present invention relates to isothiazoline compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for combating or controlling invertebrate pests, in particular arthropod pests ...
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JP6412141B2 |
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JP6410146B2 |
To provide a novel sulfur-containing compound useful as a positive electrode active material, which can substantially improve charge/discharge capacity and cycle characteristics of a lithium ion secondary battery while using a material t...
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JP2018530594A |
To use a novel compound, YAP / TAZ-TEAD interaction inhibitor, in the treatment of malignant mesothelioma. The present invention relates to a compound of formula (I) (in the formula, R).1, R2, R3, R4, R5, And R6Is as defined in the speci...
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JP6407987B2 |
wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for control...
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JP6385560B2 |
The present invention relates to a new compound of formulawherein the variables have the meaning as indicated in the claims; or an enantiomer or salt thereof. The compounds of formula (I) are useful in the control of parasites, in partic...
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JP6370377B2 |
The present invention primarily relates to salts of Dasatinib, wherein the salts are in amorphous form. The salts described herein preferably comprise a cation of a compound of formula 1 and an anion of a second compound selected from th...
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JP6363702B2 |
The present invention relates to bicyclyl-substituted isothiazoline compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in p...
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JP2018515597A |
Described are inhibitor compounds and agents of cathepsins C, CELA1, CELA3A and / or molecules structurally related thereto, compositions containing them, and their use in the suppression and / or prevention of cell and / or tissue necro...
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JP2018087185A |
To provide a novel agrochemical, particularly a herbicide.The present invention provides an oxime compound represented by formula (1) [where B is B-1, B-2 or B-3, Q is NORand the like, Ris C-Calkyl and the like, Ris (C-C) alkyl, optional...
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JP6337135B2 |
The present invention provides compounds and pharmaceutical compositions for treating neurological diseases such as multiple sclerosis.
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JP2018076265A |
To provide a diamine derivative or a salt thereof, a method for producing the same, and a pest disease control agent for agricultural and horticultural use containing the derivative or the salt thereof as an active ingredient.The present...
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JP6325449B2 |
The present invention provides a compound having a lysine specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, Alzheimer's disease, Parkinson's disease or Hun...
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JP6303031B2 |
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPRI20 receptor. Such compounds are represented by Formula (I) as follows: wherein R 1, G, and Q are defined herein.
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JP6293770B2 |
The invention relates generally to the creation and use of cyclic sulfonamide containing derivatives to inhibit the hedgehog signaling pathway and to the use of those compounds for the treatment of hyperproliferative diseases and angioge...
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JP6290236B2 |
A method for preparation of 2-alkyl-1,2-benzisothiazolin-3-ones from 1,2-benzisothiazolin-3-one by contacting 1,2-benzisothiazolm-3-one with a dialkyl carbonate in the presence of a base.
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JP2018501252A |
The present invention relates to the art of herbicides and / or plant growth regulators. In particular, the present invention first relates to novel isothiazole amides and compositions comprising said novel isothiazole amides. Furthermor...
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JP2018501251A |
The present invention relates to novel isothiazole amide derivatives, methods for preparing these compounds, compositions containing these compounds, and for controlling harmful microorganisms in crop protection and in material protectio...
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JP6262228B2 |
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, p, q, r, A, W, X1, X2, X3, X4, Y, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, and R12 are as defined herein. Also disclosed are methods of makin...
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JP2017538659A |
The present disclosure is based on formula (I) :.Carboxamides and sulfonamides represented by (where A, Y, B, X, and Z are defined herein) and pharmaceutically acceptable salts and solvates thereof. provide. The present disclosure also r...
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JP2017218444A |
To provide a novel compound and a herbicide prepared using the same.The present invention provides a ketone or oxime compound represented by formula (1) [B is B-1, B-2 or B-3; Q is O, NORor the like; m and n are an integer of 0-2; R, R, ...
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JP6223336B2 |
Compounds of formula (I) or a pharmaceutically acceptable ester, amide, carbamate or salt thereof, including a salt of such an ester, amide or carbamate in which R1 to R9 have meanings as defined in the Specification, are useful as estro...
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JP6218916B1 |
[Subject] Control a fall of a function of the magnetic particle itself and provide magnetic particle dispersion liquid which are excellent in preservation stability. [Means for Solution] Magnetic particle dispersion liquid containing a m...
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JP6215890B2 |
The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention also relates to methods for their preparation, pharmaceutical compositions cont...
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JP6205406B2 |
New tranilast complexes and new tranilast cocrystals are disclosed. These include a 1:1 tranilast nicotinamide complex, a 1:1 tranilast nicotinamide cocrystal, a 1:1 tranilast saccharin complex, a 1:1 tranilast saccharin cocrystal, a 1:1...
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JP6200495B2 |
The present invention is to provide a novel ±-substituted glycinamide derivative, or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a pharmaceutical use thereof. The present invention p...
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JP6198268B2 |
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JP6163647B2 |
Disclosed are benzoisothiazole compounds and a use in the preparation of anti-schizophrenia drugs. The benzoisothiazole compounds of the present invention not only have strong affinity for dopamine D 3 receptor, 5-HT 1A receptor and 5-HT...
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JP2017081931A |
To provide antibacterial agents which can prevent infections cause by gram-negative bacteria, other compounds for use in the preparation of medicines and combinations of such compounds.The present invention provides a compound represente...
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JP2017512184A |
In the present invention, the amino-substituted isothiazoles of the general formula (I) [A, R1 and R2 are as defined in the claims. ], Methods of making the compound, intermediate compounds useful in the manufacture of the compound, phar...
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JP2017511374A |
The present invention relates to drugs for preventing and treating RNA-containing viruses and diseases caused by DNA-containing viruses, and complications, and to prevent and treat diseases caused by RNA-containing viruses and DNA-contai...
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JP2017511304A |
A novel compound having the following formula, a mode of a method for producing the same, and a mode of a composition containing the same are disclosed herein. A method of treating or preventing metabolic disorders in a subject, comprisi...
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JP2017507921A |
In one aspect, the present invention relates to formula (I): (in formula, R).1~ R6With respect to a compound having (as defined herein), or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibitory activity. ...
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JP2017043561A |
To provide a manufacturing method of an isothiazole-5-methanol compound represented by the formula (1), under an industrially preferable condition at high yield and without passing an unstable intermediate for stable supply.There is prov...
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JPWO2014199960A1 |
The present invention relates to schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorder (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic ...
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JP6078526B2 |
Provided is an acrylic acid ester derivative which, when used as a constituent unit of a polymer which is included in a photoresist composition for a semiconductor, exhibits excellent lithography characteristics such as LWR and the like....
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JP6078338B2 |
A method for producing a 3-halo-1,2-benzisothiazole represented by the general formula (2): wherein R 1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms, an alkoxycarbonyl group ha...
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