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JP5039375B2 |
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JP5040656B2 |
It is intended to provide an agent for treating or preventing hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinopathy and so on which has a non-nucleic acid structure and exerts an excellent xanthine o...
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JP5025652B2 |
An amide is formed by reacting an α-ketoacid or salt thereof in a decarboxylative condensation reaction with an amine or salt thereof comprising a nitrogen covalently bound to an atom selected from oxygen, nitrogen, and sulfur. The amid...
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JP2012162534A |
To provide multifunctional compounds having acylsulfonamide amine-reactive groups that can be used for the capture of amine containing materials.The compounds are provided that has a functional group equivalent to -SO2-N(COR1)(COR2) in a...
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JP5015605B2 |
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JP5015152B2 |
Compounds of formula (I) exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.
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JP2012153726A |
To provide a GPR40 activator having, as an active ingredient, a compound having a new GPR40 agonist effect, a salt thereof, a solvate of either or the like, above all, an insulin secretagogue, a prophylactic and/or therapeutic agent for ...
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JP5002077B2 |
[Problem] To provide a GPR40 activating agent having, as an active ingredient, a novel compound having a GPR40 agonist action, a salt of the compound, a solvate of the salt or the compound, or the like, particularly, an insulin secretago...
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JP5000645B2 |
Method for preparing 3,4-dichloroisothiazole carboxylic acid (I) comprises (a) reacting a cyanide, carbon disulfide and chlorine to form 3,4-dichloroisothiazole carbonitrile (II), then after distilling out solvent, treatment with an alco...
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JP2012517454A |
The present invention provides phenoxyacetic acid derivatives of Formula (I) for the treatment of CRTH2 related disorders and disease selected from asthma, atopic dermatitis and inflammatory dermatoses.
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JP4990270B2 |
The present invention is directed to modulators of indoleamine 2,3-dioxygenase (IDO), as well as compositions and pharmaceutical methods thereof.
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JP4988128B2 |
The present invention relates to a beta3 adrenergic receptor agonist of formula I: or a pharmaceutical salt thereof; which is capable of increasing lipolysis and energy expenditure in cells and, therefore, is useful for treating Type II ...
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JP4974415B2 |
The present invention relates to novel aryl-substituted S(O)m cycles of the formula (I):in whichF<1>, F<2>, G, V, W, X, Y, Z and m are each as defined in the description, to processes for their preparation and to their use in agriculture...
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JP4971946B2 |
The invention relates to hydrochloride, hydrobromide, hemi-citrate, acetate, p-tosylate, L-tartrate, hemi-succinate, and mesylate salt forms of 3-(4-bromo-2,6-difluoro-benzyloxy)-5-[3-(4-pyrrolidin-1-yl-b
utyl)-ureido]-isothiazole-4-carb...
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JP4922507B2 |
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JP2012508176A |
The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods for treating conditions and d...
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JPWO2010044371A1 |
Sweet receptor agonists such as Acesulfarm K, sucralose, saccharin or glycyrrhizin are used as active ingredients of insulin secretagogues. In addition, a test compound is added to cells expressing a sweet taste receptor, the sweet taste...
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JP4889737B2 |
Provided is a process for the preparation of an N-substituted isothiazolinone derivative having the general formula (I), comprising reacting N-substituted 3-mercaptopropionamides of formula (II) or N,N′-bis-substituted 3,3′-dithiodip...
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JP4861191B2 |
Detection systems for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g....
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JP4856312B2 |
Novel isothiazolecarboxamides of the formulain whichR is as defined in the description,a plurality of processes for preparing the novel compounds and their use for protecting plants against attack by undesirable microorganisms.
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JP4856314B2 |
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JP2012006982A |
To provide compounds that are capable of modulating activity at CXC-chemokine receptors.This invention relates to: novel CXCR1 and CXCR2 chemokine antagonists, pharmaceutical compositions containing the compounds; and methods of treatmen...
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JP4851943B2 |
Disclosed are novel compounds of the formula: and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein one is N and the other is CR50. Examples of groups comprising Substituent A include hetero...
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JP2012500260A |
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels of MIF expression.
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JP4830301B2 |
To provide a compound having an excellent controlling effect against harmful organisms. This compound expressed by formula (I) [wherein, any one of X1to X4is CR100and others are each N or CR5, provided that 1-3 of the X1to X4are each N; ...
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JP4824580B2 |
Detection systems for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g....
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JP4826282B2 |
The present invention relates to a diketohydrazine derivative of formula (I) and a pharmaceutically acceptable salt thereof (the symbols in the formula have the same meaning as described in the specification). The compound of formula...
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JP4810427B2 |
Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
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JP4810529B2 |
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to formula (I) where Ar, R<1>-R<5>, R<11c >and X<1> are as defined herein.
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JP4789950B2 |
An alkoxylpropyl isothiazolinone of formula: C 6 H 6 Cl 2 NO 2 SR, in which R is CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , CH 2 CH 2 CH 2 CH 3 , CH 2 CH 2 OCH 3 or CH 2 CH 2 OC 6 H 5 Cl. A method for preparing the isothiazolinone by reacting sodi...
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JP4785169B2 |
The present invention generally relates to methods of inhibiting ethylene responses in plants and plant materials, and particularly relates to methods of inhibiting various ethylene responses including plant maturation and degradation, b...
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JP2011524859A |
A compound of Formula (I) or Formula (II) where W is C-R3; X is C-R4; Y is C-R5; R1 and R6, independently of each other, is, for example, H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl or C1-C6-alkyl-C(=O); R2 is H; and R...
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JP4762250B2 |
The present invention relates to compounds of the general formula I wherein R1 is the group and R2, R', R'', R3, R4, R5, R6, R7, X1, X1', X2, and N are as defined in the specification. Compounds of the invention are useful for the treatm...
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JP2011162465A |
To provide an efficient method for producing a benzoisothiazolinone-1-oxide compound.The benzoisothiazolinone-1-oxide compound represented by formula (A) is obtained by reacting a sulfinate salt compound represented by formula (B) with a...
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JP4750272B2 |
Compounds of formula I wherein: W is -OH or -NHOH; X is an optionally substituted heterocycle, -NR 1 SO 2 R 2 , heterocyclylalkylthio; -CONR 2 R 3 , or-NR 1 COR 2 , Y, Z, R 1 -R 3 and n are as defined in the application. Compounds (I) ar...
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JP4745609B2 |
The invention provides non-steroidal ligands for the glucocorticoid receptor, methods for making non-steroidal ligands of the glucocorticoid receptor, compositions of non-steroidal ligands of the glucocorticoid receptor and methods of us...
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JP4737583B2 |
The invention relates to pharmaceutical salts comprised of a pharmaceutical active substance, particularly N,N-dimethylaminopropylphenol compounds or tradamol, and of at least one sugar substitute such as saccharin, cyclamate or acesulfa...
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JP2011144155A |
To provide a new clathrate compound that has equal duration of medicinal benefits and a lower initial elution rate of CMI (5-chloro-2-methyl-4-isothiazolin-3-one) compared with a clathrate compound of a tetrakisphenol compound and CMI.Th...
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JP2011127044A |
To provide an azo pigment and an azo compound excellent in chromatic characteristics such as coloring power and a hue, and also excellent in durability such as light resistance.An azo pigment or azo compound represented by general formul...
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JP4713465B2 |
The invention encompasses 7-amido-isoindolyl compounds and methods of using these compounds and compositions in mammals for treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, ...
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JP4706810B2 |
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JP2011098984A |
To provide a compound capable of controlling activity in a CXC-chemokine receptor.There are disclosed novel compounds of formula (IA), and the pharmaceutically acceptable salts and solvates thereof. D and E are different groups wherein o...
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JP4682315B2 |
The invention relates to fungicide and insecticide, especifically to the substituted azole compounds and its preparation method and use thereof. The azole compounds of the invention having general formula (I): The compounds of present in...
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JP4679781B2 |
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JP2011079843A |
To provide pharmaceutical salts containing a pharmaceutically-active compound and at least one sugar substitute, and a drug containing these salts.The present invention relates to the pharmaceutical salts of a (1RS, 3RS, 6RS)-6-dimethyla...
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JP4673748B2 |
An object of the present invention is to provide a compound represented by Formula (1): wherein A 1 , A 2 , A 3 and A 4 each represent a carbon atom, a nitrogen atom or an oxidized nitrogen atom; R 1 and R 2 each represent a hydrogen ato...
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JP4653486B2 |
Compounds of formula I: inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.
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JP2011506519A |
The present invention provides a compound of formula (1) or a pharmaceutically acceptable salt thereof: wherein R1 represents optionally substituted C1-4 alkyl; X represents —(CR10R11)n— in which n represents 1 or 2; R2, R3 and R4 in...
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JP4633725B2 |
A description follows of 1,3-diones having general formula (I): together with their use as herbicides for the control of weeds in agricultural crops.
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JP4632502B2 |
To provide a method for producing a high-purity 1,2-benzisothiazol-3- one. This method for producing the objective 1,2-benzisothiazol-3-one of the general formula (2) (wherein, R2 means the same as described in the general formula (1)) i...
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