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JP2011504505A |
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory di...
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JP4628102B2 |
The present invention provides a synthesis for the preparation of epothilone derivatives of formula 9 wherein R1 is methyl, and R2 is an unsubstituted or substituted aryl; an unsubstituted or substituted heteroaryl; or an unsubstituted o...
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JP4619543B2 |
An improved process for the preparation of 6-(perfluoroalkyl)uracil compounds having structural formula (I) from carbamate compounds having structural formula (II).
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JP4619542B2 |
An improved process and intermediate compounds (N) for the preparation of 2-(N,N-disubstituted)amino-4-(perfluoroalkyl)-1,3-oxazin-6-o
ne compounds having structural formula (I) and an improved process for the preparation of 6-(perfluoro...
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JP4619544B2 |
An improved process for the preparation of 6-(perfluoroalkyl) uracil compounds having structural formula (I) from urea compounds having structural formula (II).
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JP4620123B2 |
The invention is concerned with novel hexafluoroisopropanol substituted ether derivatives of formula (I): wherein R1 to R3 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereo...
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JP4601901B2 |
This invention relates to compounds of formula I their salts, and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions comprising these compounds and their use in the treatment of picornavirus infections in mammal...
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JP4603160B2 |
A composition comprising a C3-5-alkyl-1,2-benzisothiazolin-3-one and the metal complex of a cyclic thiohydroxamic acid such as the 2:1 zinc salt of either 3-hydroxy-4-methylthiazol-2(3H)-thione or 1-hydroxypyridine-2-thione.
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JP4585522B2 |
α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is s...
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JP2010535172A |
The present invention relates to methods of treating CNS disorders with a compound of formula I wherein X, R1, R2, R3, R4, R5, R6, R7, and R8 are as defined in the specification and pharmaceutically acceptable acid addition salts thereof.
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JP2010260805A |
To provide an efficient method of producing 3,4-dichloro-5-cyanoisothiazole at a high yield, which can easily be practiced on an industrial scale without using a highly toxic raw material. The method of producing 3,4-dichloro-5-cyanoisot...
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JP2010260811A |
To provide an agricultural and horticultural plant disease injury controller comprising a nitrogen-containing five-membered heterocyclic derivative exhibiting high control effects on agricultural and horticultural plant disease injuries ...
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JP4574167B2 |
A process for the synthesis of oligonucleotides using phosphoramidite chemistry is provided. The process employs as activator a 1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one, preferably in the presence of an organic base. The 1,1-d...
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JP2010248217A |
To provide new isothiazolecarboxylic acid amides suitable for protecting plants from attack of undesirable microorganisms and also suitable as a microbicidal agent to directly control the microorganisms.There are provided a compound expr...
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JP4571507B2 |
Tetracyclic 3-substituted indoles having serotonin receptor affinity and pharmaceutically acceptable salts thereof.
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JP4551763B2 |
The invention relates to a novel one-pot method for producing 3,4-dichloro-N-(2-cyano-phenyl)-5-isothiazole carboxamide. According to said method, a) isatoic acid anhydride is reacted with ammonia gas in the presence of dimethylformamide...
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JP4553416B2 |
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JP4551762B2 |
The invention relates to a novel method for producing 3,4-dichloro-N-(2-cyano-phenyl)-5-isothiazole carboxamide. According to said method, a) 3,4-dichloro-isothiazole-5-carboxylic acid chloride is reacted with anthranilic acid amide in t...
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JP4547898B2 |
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JP2010195787A |
To provide a compound useful for PDE IV and TNF inhibitor.There is provided a compound, an N-oxide, or a pharmaceutically acceptable salt of the formula wherein R1 is optionally substituted lower alkyl; R2 is optionally substituted cyclo...
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JP2010189434A |
To provide antiviral agents especially compounds useful for treatment of infection caused by Picornaviridae such as human rhinovirus (HRV), and to provide a method for producing them.There are provided compounds of formula I, salts there...
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JP4534452B2 |
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JP4530543B2 |
Phenethylsulfones substituted alpha to the phenyl group with a 1-oxoisoindoline or 1,3-dioxoisoindoline reduce the levels of TNF alpha in a mammal. A typical embodiment is 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-ami
nois...
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JP4528901B2 |
This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is optionally substituted lower alkyl, Y is -S(O)n- wherein n is 1 or 2, or -CO-, R 2 is hydrogen or lower alkyl, R...
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JP2010173954A |
To provide a method for efficiently producing a 1,2-benzoisothiazole compound.The method for producing the 1,2-benzoisothiazole compound represented by formula (A) (wherein, substituent R1 is hydrogen, 1-8C alkyl or 6-10C aromatic; subst...
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JP2010527344A |
This invention pertains generally to the field of therapeutic compounds, and more particularly, to certain bicyclosulfonyl acid (BCSA) compounds which act as inhibitors of Tumour Necrosis Factor-α Converting Enzyme (TACE). The compounds...
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JP4521283B2 |
This invention is directed to a [di(ether or thioether)heteroaryl or fluoro substituted aryl] compound or an N-oxide thereof or a pharmaceutically acceptable salt thereof, which is useful for inhibiting the production or physiological ef...
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JP4511720B2 |
Novel isothiazolecarboxylic acid derivatives of the formulain whichR is as defined in the description,a process for preparing the novel compounds and their use for protecting plants against attack by undesirable microorganisms and animal...
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JP2010524954A |
The present application relates to isothiazolylidene containing compounds of Formula (I) wherein R1, R2, R3, R4, and L are as defined in the specification, compositions comprising such compounds, and methods of treating conditions and di...
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JP2010155983A |
To provide an azo pigment excellent in coloring power, color characteristics, and durability, and a pigment dispersion. The azo compound is represented by general formula (2). In the formula: G2is H, an alkyl group, an aryl group or a he...
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JP4498472B2 |
PCT No. PCT/GB97/03130 Sec. 371 Date Jun. 18, 1999 Sec. 102(e) Date Jun. 18, 1999 PCT Filed Nov. 13, 1997 PCT Pub. No. WO98/28283 PCT Pub. Date Jul. 2, 1998A process for making a 1,2-benzisothiazolin-3-one by cycling a bisamide precursor...
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JP4492891B2 |
A liquid concentrate comprises between 4 and 25 wt% of 4,5-dichloro-2-(n-octyl-4-isothiazolin-3-one), between 25 and 88 wt% of a plasticizer in which said isothiazolinone compound is soluble and between 8 and 50 wt% of benzyl alcohol whi...
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JP2010132672A |
To provide a method for treating or preventing obesity, diabetes, anxiety, depression, neurodegeneration, or inflammatory diseases. There are provided a nonsteroidal ligand for glucocorticoid receptors, a method for producing a nonsteroi...
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JP4478025B2 |
The invention provides compounds of formula I: which are inhibitors of gamma-secretase and hence useful in the treatment or prevention of Alzheimer's disease.
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JP2010519277A |
A compound of general formula (I): A process for preparing this compound. A fungicidal composition comprising a compound of general formula (I). A method for treating plants by applying a compound of general formula (I) or a composition ...
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JP4469969B2 |
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JPWO2008102908A1 |
Providing new herbicides. General formula (1):[In the formula, Q is -N (R)5) SO2R6Represents R5And R6Represents an alkylene or the like that may be bonded to each other to form a ring. ] Is a haloalkyl sulfone anilide derivative or a sal...
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JP2010516826A |
The present invention provides dyes of the general formula (I) where D is the residue of a diazo component; R1 to R7 and L are each as defined in claim 1, processes for their preparation and their use.
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JP2010516724A |
The invention provides 3-amino-1,2-benzisothiazole compounds of formula (I) wherein n, R1, R2, R3, R4 and A are defined as in the description. The invention provides further agricultural compositions comprising an amount of at least one ...
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JP4447909B2 |
Novel compounds of formula (I), wherein D, W, X, Y, T and R1 have the meanings cited in claim 1 , are inhibitors of coagulation factor Xa and can be used for the prophylaxis and/or therapy of thromboembolic diseases and in the treatment ...
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JP4443037B2 |
This invention relates to peptide-containing alpha-ketoamide inhibitors of cysteine and serine proteases, methods for making these compounds, and methods for using the same.
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JP2010508288A |
A compound of Formula I and enantiomers, diastereomers and pharmaceutically-acceptable salts thereof. Also disclosed are pharmaceutical compositions containing compounds of Formula I, and methods of treating conditions associated with th...
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JP4432901B2 |
Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): Äwherein X<1> represents oxygen, etc., X<2> represents oxygen, etc., R<1> represents a grou...
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JP4434740B2 |
Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
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JP2010047480A |
To provide a new method for preventing various pest damages in plant seeds or crops of agricultural plants.There is provided the method for preventing the insect damages, characterized by applying an insecticidal composition containing a...
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JP2010047478A |
To provide a new pest control composition which can simultaneously control pests that can not or hardly be controlled by one of insecticides, miticides and fungicides.There is provided the pest control composition characterized by compri...
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JP4423022B2 |
To provide a new 2,1-benzoisothiazole compound. The 2,1-benzoisothiazole compound is represented by general formula [I] (wherein, R1 to R5 are each a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substitute...
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JP2010043255A |
To provide an azo pigment and a pigment dispersion having excellent color characteristics such as coloring power and hue and exhibiting high durability such as light resistance.The azo pigment represented by formula (1), its tautomer, an...
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JP4418230B2 |
Compounds of general formula (I): in which: Het represents a five or six membered saturated, partially unsaturated or aromatic ring containing between one and six heteroatoms of the group N, O, S, in which the heterocycle is substituted ...
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JP2010031025A |
To provide antiviral agents, compounds useful for treating of infection resulting from Picornaviridae especially like human rhinovirus, HRV, and methods of manufacturing them.The invention relates to compounds of formula I, their salts, ...
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