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Matches 1 - 50 out of 9,407

Document Document Title
WO/2019/199621A1
The present invention is directed to bi-functional compounds which find use as pharmaceutical agents in the treatment of disease states and/or conditions which are through.macrophage migration inhibitory factor (MIF) or immunoglubin G (I...  
WO/2019/196262A1
The present invention relates to the field of pharmaceutical synthesis, and in particularly relates to a preparation method for a hexahydrofuro-furan-ol derivative, and an intermediate of the derivative and a preparation method therefor....  
WO/2019/199634A1
The present invention is directed to bifunctional small molecules which contain a circulating protein binding moiety (CPBM) linked through a linker group to a cellular receptor binding moiety (CRBM) which is a membrane receptor of degrad...  
WO/2019/185026A1
Disclosed are a class of glucoside derivatives which act as SGLT1/SGLT2 dual inhibitors, and a use of same in the preparation of drugs acting as SGLT1/SGLT2 dual inhibitors. The derivatives are compounds represented by formula (I), isome...  
WO/2019/191352A1
Disclosed herein are methods, sodium-dependent glucose transporter (SGLT)1 compounds and compositions for the treatment of postprandial hypoglycemia, postprandial hypoglycemia that occurs as a consequence of gastric surgery.  
WO/2018/213150A8
The application relates to phenyl- or naphthylsulfonamide derivatives of the structural formula (I). The compounds are described as inhibitors of USP30 (ubiquitin specific peptidase 30) useful for the treatment of conditions involving mi...  
WO/2019/188717A1
The present invention addresses the problem of providing a compound which is capable of forming a radical polymerization initiator that exhibits excellent heat resistance and solubility. The present invention is a compound represented by...  
WO/2019/171278A1
The present invention is directed to heterocycloalkenyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the GPR120 and / or GPR40 receptors. 5 More particul...  
WO/2019/173772A1
The present disclosure is directed to l-(2-hydroxy-4-methylcyclohexyl)-ethanone derivatives having unique and desired flavor and/or fragrance characteristics, as well as the synthesis and application of the derivatives. The compounds of ...  
WO/2019/145726A9
Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases an...  
WO/2019/172830A1
The present disclosure concerns use of compounds of formula I, or salts thereof, as reactive matrices for desorption and laser ablation ionization spectrometry. The disclosure further concerns compounds of formula II, or salts thereof, a...  
WO/2019/166958A1
Sotagliflozin may be prepared using schemes and intermediates disclosed herein. Sotagliflozin may be incorporated into pharmaceutical dosage forms for treatment of diabetes.  
WO/2019/166019A1
Disclosed in the present invention are pyran fused ring compounds, preparation methods therefor and the use thereof, in particular pyran fused ring compounds which can be used for preparing halichondrin, eribulin or analogues thereof, pr...  
WO/2019/168866A1
Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods,...  
WO/2019/159957A1
Provided is a polymerizable compound represented by formula (1). In formula (1), one of eight hydrogen atoms is substituted with a (meth)acryloyloxy group, and the remaining seven hydrogen atoms are independently either unsubstituted or ...  
WO/2019/160150A1
This novel valerolactone-based compound is represented by formula (I). [In the formula, X represents an allyl group, an aryl group, an ethynyl group, or a butenyl group. Y represents a single bond or a hydroxymethylene group, and Z repre...  
WO/2019/155485A1
The present invention relates to the process for the preparation of Pyrylium salts having the formula represented below. Present invention provide a simplified method of producing symmetrical and unsymmetrical pyrylium salts. The inventi...  
WO/2019/156074A1
The present invention addresses the problem of providing a novel compound for the treatment and/or prevention of pain, which has excellent skin penetrability and is less irritative to the skin. The means for solving the problem is a comp...  
WO/2019/144864A1
Provided are a glucopyranosyl derivative as a sodium-dependent glucose transporters inhibitor, especially as a SGLT1 inhibitor, a pharmaceutically acceptable salt or a stereoisomer thereof, a pharmaceutical composition thereof, and the u...  
WO/2019/145158A1
The present invention relates to the use of substituted bis-4H-pyranonyl compounds in which the 4H-pyranonyl units are combined with heteroalkyl groups, in detergents and cleaning agents, for improving detergent or cleaning performance w...  
WO/2019/145726A1
Compounds of general formula (I): wherein R1, R2, R3, R4, R5a, R5b X1, X2, Z and Y are as defined herein are positive modulators of the calcium-activated chloride channel (CaCC), TMEM16A. The compounds are useful for treating diseases an...  
WO/2019/134667A1
A compound as an SGLT1/SGLT2 dual inhibitor, and an application thereof in the preparation of a drug as the SGLT1/SGLT2 dual inhibitor. The compound is a compound represented by formula (I), an isomer thereof, or a pharmaceutically accep...  
WO/2019/132784A1
This invention relates to a catalyst composition for a producing process of an unsaturated carboxylic acid salt and its derivatives from carbon dioxide and olefin, wherein the catalyst composition in the present invention has been proved...  
WO/2019/121509A1
The invention relates to a process for the manufacture of the crystalline compound according to formula (I) comprising the steps (a) deacetylating the final intermediate (FT), (b) forming the crystalline compound according to formula (I)...  
WO/2019/116069A1
The invention relates to compounds of formula (I), their method of synthesis as well as their use to treat neurodegenerative disorders.  
WO/2019/111865A1
Provided is a method for producing a cyclic ether represented by formula (2), wherein a 2-hydroxy cyclic ether represented by formula (1) is reacted with hydrogen in the presence of a catalyst.  
WO/2019/106122A1
The invention describes novel conjugates of formula (I) of a pharmaceutical agent and a moiety capable of binding to a glucose sensing protein allowing a reversible release of the pharmaceutical agent depending on the glucose concentration.  
WO/2019/104850A1
Disclosed is a method for preparing a lactone compound, for which a cyclic ketone compound serves as a raw material; in an oxygen-containing atmosphere, a cyclic organic nitroxide free radical serves as a catalyst, and a certain amount o...  
WO/2019/090088A1
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.  
WO/2019/087145A1
Aromatic amides are described, having general formula (I), suitably substituted and having a high fungicidal activity, together with their use for controlling phytopathogenic fungi of important agricultural crops.  
WO/2019/077106A1
The present invention relates to new compounds of general formula (I) showing great affinity and activity towards the subunit α2δ of voltage-gated calcium channels (VGCC), especially the α2δ-1 subunit of voltage-gated calcium channel...  
WO/2019/068856A1
The present invention relates to aroma chemical compositions containing 3,5-diethyl-2-propyl-tetrahydropyran, a 3,5-diethyl-2-propyl-dihydropyran or a 3,5-diethyl-2-propyl-pyran, a mixture of such compounds, a stereoisomer of one of thes...  
WO/2019/061299A1
Provided is a one-step amination reaction for producing an aminomethyl substituted heterocycloalkane, notably (tetrahydrofuran-2, 5-diyl) dimethanamine.  
WO/2019/066467A1
Provided in the present invention are: a novel method for preparing a compound of chemical formula 1, comprising a step of obtaining a compound of chemical formula 1 by performing a reduction reaction on a compound of chemical formula 2;...  
WO/2019/032936A8
Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions ...  
WO/2019/058890A1
The present invention provides an active light sensitive or radiation sensitive resin composition which has an excellent LER. Furthermore, provided are: a resist film; a method for forming a pattern; and a method for manufacturing an ele...  
WO/2019/059555A1
Disclosed are: a trimethoxy phenyl compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof; and a composition for promoting hair growth or restoration, containing the same as an act...  
WO/2019/039290A1
Provided are: an actinic ray-sensitive or radiation-sensitive resin composition that has excellent resolution, exposure latitude, and pattern shape properties; and a resist film, a pattern-forming method, a method for producing an electr...  
WO/2019/037862A1
The invention relates to organosulphur compounds which can be obtained from rose oxide, to methods for producing said organosulphur compounds and their use as odorants, flavourings or constituents of odorant mixtures and the products der...  
WO/2019/035408A1
The present invention provides a method for producing a compound (i) having a group represented by a partial structure (A), a partial structure (AI), a partial structure (D), or a partial structure (DI), and a group represented by a part...  
WO/2019/032936A1
Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions ...  
WO/2019/032956A1
Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the C-7 position of the aminooctose (northern) region, thus distinguishing them from lincomycin and clindamyci...  
WO/2019/032941A1
Provided are lincosamide compounds for the treatment of infectious diseases. The lincosamides described herein are modified at the amino acid (southern) region. The lincosamides may have further modification at the C-1 and C-7 positions ...  
WO/2019/030284A1
The present invention is directed to novel natural product-derived ratjadone-based compounds useful as payloads (or toxins) in drug-conjugates constructs with cell target binding moieties (CTBM) and payload-linker compounds useful in con...  
WO/2019/022294A1
The present invention relates to a novel compound represented by following formula 2 produced by means of marine-derived fungus Penicillium sp. and a composition for improving skin wrinkles, enhancing elasticity and skin whitening using ...  
WO/2019/015583A1
The present invention provides compounds of Formula (I) which can be used as ACC inhibitors and potently as therapeutic agents against diseases mediated by ACC.  
WO/2019/016314A1
The present invention relates to an improved method for producing 3,7-dimethyl- 9-(2,6,6-trimethyl-1 -cyclohexen-1 -yl)-nona-2E,7E-dien-4-yne-1,6-diol.  
WO/2019/009412A1
The present invention addresses the problem of providing a novel compound having high LSD1 inhibitory activity, high selectivity for LSD1 inhibition, and/or having useful therapeutic effects for various diseases. One embodiment of the pr...  
WO/2019/008156A1
The present invention provides novel compounds of formula (I) that are useful as inhibitors of the PD-1/PD-L1 protein/protein interaction. The compounds may be used in the treatment of cancer, infectious diseases and neurodegenerative di...  
WO/2018/229013A1
The invention concerns a method for obtaining a free glucaric acid solution from a solution comprising non-free glucaric acid, water and at least one other constituent including at least one ion, characterised in that it comprises the fo...  

Matches 1 - 50 out of 9,407