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Matches 551 - 600 out of 1,583

Document Document Title
WO/1996/034004A1
The invention provides a novel endo-type fucoidan hydrolase and a novel microorganism useful for producing sugar compounds. The sugar compounds refer to the compounds represented by general formula (1), wherein at least one alcoholic hyd...  
WO/1996/029339A1
Compounds of formula (I) wherein R is CH3 and R1 is a peptidic residue or R1 is OH and R is a peptidic residue have pharmacological activity as sialyl Lewis X mimetics, e.g. in the prevention or treatment of disorders or diseases which a...  
WO/1996/023509A1
The combination of the HIV protease inhibitor Compound J, 3TC, and, optionally AZT, ddI, or ddC, is useful in the inhibition of HIV protease, the inhibition of HIV reverse transcriptase, the prevention or treatment of infection by HIV an...  
WO/1996/023479A2
The invention concerns the use of a compound or a number of compounds from the group of the carbohydrates or carbohydrate derivatives as anti-adhesive active principles directed against micro-organisms, parasites and protozoa.  
WO/1996/020717A1
Disclosed herein are antifungal compositions having an oligosaccharide that includes an N-acetylhexosamine residue linked 'beta'(1}4) to a hexose and a biologically acceptable carrier. The isolation of the fungal enzyme chitin glucan 'be...  
WO/1996/013258A1
The present invention provides breast cancer chemopreventive arylamide analogues of retinoic acid, more particularly C-glycoside analogues of N-(4-hydroxyphenyl)retinamide-O-glucuronide and N-glycoside analogue of retinoyl 'beta'-glucuro...  
WO/1996/005211A1
A ganglioside GM3 analog having the sialic acid residue fluorinated at the 9-position, represented by general formula (I), and an intermediate therefor, wherein R represents lower aliphatic acyl; R1 represents hydrogen or lower alkyl; R2...  
WO/1996/003357A1
A process for the preparation of a selectively fluorinated organic compound, which process includes reaction of a precursor of said organic compound, the precursor containing at least one Group VI element selected from sulfur, selenium a...  
WO/1995/034571A2
It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide poly-O-sulphonic acid salts of antibiotics s...  
WO/1995/023807A1
Novel pseudoceramides of formulae (Ia) and (Ib) are proposed, (Ia) (Ib) in which R1 stands for a linear or branched alkyl and/or alkenyl residue having 6 to 30 carbon atoms, Y stands for oxygen or an NR5 group, R2 stands for hydrogen or ...  
WO/1995/021850A1
Methods are provided for generating highly diverse mixtures of compounds which may be screened for biological activities. Once the activity is found, the component of the mixture which is responsible for the activity can be isolated by f...  
WO/1995/017903A1
The design and synthesis of novel oxazolone-derived molecular modules and the use of the modules in the construction of new molecules and fabricated materials is disclosed. The new molecules and fabricated materials are molecular recogni...  
WO/1995/015309A1
Compounds selected from those of general formula [A-B (Groups I and II)] and (group III), (1, 2 and 3) where B is (4) and A is selected from specified aminoacyl compounds are inhibitors of DP-IV mediated processes.  
WO/1995/014028A2
Novel methods for the treatment and/or prophylaxis of diseases caused by tissue-adhering bacteria are disclosed. By interacting with periplasmic molecular chaperones it is achieved that the assembly of pili is prevented or inhibited and ...  
WO/1995/014026A1
The invention relates to 'beta'(1}6) glucosamine disaccharides having general formula (I) to a method for preparing these disaccharides, comprising the steps of: i) providing a starting material comprising lipid A moiety of lipopolysacch...  
WO/1995/007700A1
A method for protecting against mutational damage in mammalian cells induced by irradiation comprising administering a phosphorothioate or phosphorothioate metabolite to the mammal before or up to 3 hours after irradiation.  
WO/1995/007914A1
The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid having the general formula (I): ([sucrose-octa-O-sulfonic acid8-]-[R-(NH3+)x]y-Mzn+), wherein (x . y) + (z . n) = 8, x . y N|[4 x . y 8], N is t...  
WO/1994/026756A1
Fluoro-compounds are made by reaction of an activated oxy-acid ester or cyclic ether starting material with hydrogen fluoride in the presence of an organometallic compound.  
WO/1994/022837A1
The application concerns a biologically active compound obtained by chemical synthesis and belonging to the class of heterocyclic compounds (specifically, the secondary acridones), namely: N-methyl-N-/alpha,DELTA-glucopyranozil/ammonia-2...  
WO/1994/021653A1
A method is provided for preparing [18F]2-fluoro-2-deoxyglucose with an anion exchange resin by effecting an exchange reaction between an aqueous solution of [18F]fluoride containing an alkali metal carbonate or bicarbonate, such as sodi...  
WO/1994/015623A1
This invention includes a pharmaceutical composition including a pharmaceutically acceptable carrier, urea, and hyaluronic acid or a pharmaceutically salt thereof. The invention also includes a method of treating disease of the cutis whi...  
WO/1994/011006A1
Substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, including compositions containing same and methods of using same, are disclosed for the regulation of cytokine activity in a host. For in...  
WO/1994/011381A1
Compounds of this invention are derivatives of pentose monosaccharides which exhibit anti-proliferative and anti-inflammatory activity as well as intermediates for the synthesis of these compounds. Methods of preparation, pharmaceutical ...  
WO/1994/002624A1
An enzymatic process is disclosed for the preparation of galactosylbeta1,3glycal disaccharides such as Galbeta1,3Glucal, an intermediate useful in Lea preparation and an inhibitor of beta-galactosidase. The process utilizes beta-galactos...  
WO/1993/024505A1
Disclosed are methods for reducing the degree of antigen induced inflammation in a sensitized mammal. The disclosed methods employ oligosaccharide glycosides related to blood group determinants having a type I or type Ii core structure w...  
WO/1993/024506A1
Disclosed are novel Lewis?C¿ and LacNAc analogues, pharmaceutical compositions containing such analogues, methods for their preparation and methods for their use.  
WO/1993/023163A1
Acid catalysts are prepared by reacting short-chain triglycerides having the formula (I), in which R?1¿, R?2¿ and R?3¿ represent independently from each other alkyl rests with 1 to 4 carbon atoms, with sulphur trioxide. These catalyst...  
WO/1993/017689A1
A method and pharmaceutical for protecting against genotoxic damage in irradiated cells. Reduction of mutations at the hypoxanthine-guanine phosphoribosyl transferase locus is accomplished by administering an effective dose of a compound...  
WO/1993/016087A2
Novel Amadori reaction compounds have the formula R¿1?-NH-R¿2?, wherein R¿1? comprises the D-form of a 1-amino-1-deoxy-2-ketose radical derived from a sugar radical selected from the group of glucose, xylose, galactose, rhamnose, fruc...  
WO/1993/011776A1
O-glycosylation and O-glycosylation extension inhibitors influence selectin-dependent interactions between cells and between cells and platelets.  
WO/1993/010796A1
Simple lactose or lactosamine related compounds which behave as ligands for the ELAM-1 and related receptors are described. These compounds are of formula (1) wherein each R1 is independently H or lower alkyl (1-4C); R2 is H, lower alkyl...  
WO/1993/010137A1
2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin have now been synthesized by a multistage reaction via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-alpha- and -beta-D-ribofuranosyl bromide. Also 2'-deoxy-2'-epi-2'-fluorocoformyc...  
WO/1993/008205A1
This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. ...  
WO/1993/003004A1
Amines such as methyl amine are reacted with materials such as reducing sugars in aqueous/hydroxy solvents such as water and/or methanol to prepare N-alkyl polyhydroxy amines. Accordingly, glucose is reacted with methyl amine and the res...  
WO/1993/002091A1
Broad spectrum glycosidase inhibitors are produced from monosaccharide lactams by conversion to amidines, amidrazones, or amidoximes. The inhibitors have general formula (I), wherein the N and C are joined as part of a monosaccharide aza...  
WO/1992/022662A1
Disclosed are methods for the preparation of monofucosylated and sialylated derivatives of the compound $g(b)Gal(1-4)$g(b)GlcNAc(1-3)$g(b)Gal(1-4)$g(b)GlcNAc-R. In particular, the methods of this invention provide for a multi-step synthe...  
WO/1992/022301A1
Disclosed are methods of and pharmaceutical compositions for suppressing cell-mediated immune responses including cell-mediated inflammatory responses. The disclosed methods and compositions employ oligosaccharide glycosides.  
WO/1992/019632A1
The present invention discloses trifluorofucoses and methods of making the same. Also disclosed are trifluorofucose analogs of fucose-containing oligosaccharides, and conjugates of trifluorofucose. The compounds of the present invention ...  
WO/1992/014743A2
A method and composition for the treatment of HIV and HBV infections in humans is disclosed that includes administering an effective amount of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane, a pharmaceutically acceptable deriva...  
WO/1992/008790A1
Polymer protein compounds, which include a polymer, such as a polyvinyl polymer, acrylic polymer, polyester polymer or polyamide polymer having a main chain, a linker which separates the polymer from the protein by at least two carbons, ...  
WO/1992/003472A1
The present invention provides novel peptides. These peptides have a novel non-cleavable transition state insert corresponding to the 10,11-position of the renin substrate (angiotensinogen) of formula (XL8). These peptides are useful as ...  
WO/1992/002527A1
Ligands that bind to endothelial leukocyte adhesion molecule-1 (ELAM-1) are disclosed. These ligands have the formula (I) wherein each of the saccharide rings shown is connected at its 1-position to the next saccharide at its 3-position ...  
WO/1992/000308A1
Process for producing acylated glycosyl fluorides by the fluoridation of saccharides which are at least partly O-acylated in non-aqueous hydrogen fluoride in which the corresponding carboxylic acid anhydride is added to the hydrogen fluo...  
WO/1991/015496A1
An essentially pure substance has a structure of a Nod factor or one of its analogues. The Nod factor is characterized by the fact that its biosynthesis is controlled by at least one nodulation gene (nodA,B,C) common to the Rhizobiaceae,...  
WO/1991/015497A1
In a process for producing a concentrated, stable solution of a lactose derivative from an aqueous solution containing lactose monohydrate, a chemical compound such as an alcohol capable of reacting with one of the two OH functions of th...  
WO/1991/012824A2
19F labelled compounds are disclosed which are useful in methods of NMR imaging and spectroscopy. The compounds comprise a 19F-containing sensor moiety, and a transport polymer or substrate, and can optionally also comprise a spacer moie...  
WO/1991/010672A1
The invention provides compounds of formula (I) wherein R?1� represents alkyl, R?2� represents an acid-labile protecting group and X?1� represents a halogen atom, which are useful in the synthesis of mevalonic acid derivatives.  
WO/1991/002530A1
An accelerator for periodontal tissue regeneration comprising as the active ingredient an N-acetylated amino sugar selected from the group consisting of N-acetyl-D-glucosamine, N-acetly-D-galactosamine, N-acetyl-D-mannosamine, and oligos...  
WO/1991/001326A1
Pyrimidine 4'-thionucleosides of formula (I), wherein Y is hydroxy or amino, and X is chloro, bromo, iodo, trifluoromethyl, C2-6 alkyl, C2-6 alkenyl, C2-6 haloalkenyl or C2-6 alkynyl and physiologically functional derivatives thereof. Th...  
WO/1990/014350A1
A process for producing 1-fluoro-glycuronic acids which may contain protected amino groups and their salts, in which glycopyranosylfluorides of mono or oligo-saccharides with at least one primary OH function are oxidised in aqueous solut...  

Matches 551 - 600 out of 1,583