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JPH0362717B2 |
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JPH03169890A |
NEW MATERIAL: Compounds of formula I (ring D has a double bond shown by the broken line with proviso that ring D is 16-17C containing no double bond when R2 represents two substituents or a divalent substituent; X is keto, H or OH; R1 is...
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JPH0342080B2 |
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JPH0336808B2 |
Roentgenologically amorphous escin and processes for its preparation are provided. The amorphous escin is much more soluble in water than crystalline escin, and this facilitates its employment in pharmaceutical compositions in place of c...
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JPH0316926B2 |
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JPH0331296A |
PURPOSE: To obtain a therapeutic agent for hepatopathy which markedly reduces GOT, GPT and LDH activity and has marked repressing effect against hepatic disorders by using a specific saponin as an active ingredient. CONSTITUTION: The sub...
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JPH034056B2 |
Compounds of the formula (I)or monomethyl or monoethyl ethers thereof, the compounds of formula (I) including their ethers containing no more than 30 carbon atoms in total, or esters or salts thereof; wherein Aris perylene,fluoranthene, ...
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JPH033680B2 |
DELTA <1><6> and DELTA <1><7>-21-chloro-20-keto steroids of the formula wherein n is 1 or 2, C1@C2 and C9@C11 represents a CC-single or CC-double bond, R1 is H or OH, R2 is H or CH3, R3 is H or F wherein, when R3 = F, C9@C11 is a CC-sing...
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JPH0260319B2 |
A process for preparing a 3-oxo- DELTA 1,4-steroid comprises fermenting the corresponding 3-oxo- DELTA 4-steroid, saturated in the 1,2-position, witih a living culture of Arthrobacter simplex in the presence of 0.04 g to 0.12 g of cobalt...
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JPH02240098A |
NEW MATERIAL: A compd. represented by formula I [wherein R1-R3 and each H, an alkyl, an aralkyl or an acyl, R4 is H, hydroxy, an alkoxy or an aralkoxy, (b) is a additional bond capable of existing in a case between C5 and C6, R4 is an ox...
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JPH02215796A |
NEW MATERIAL: The compound (salt) of the formula I [R is H, a 1-4C alkyl; Z is the formula (CH2)n (n is 0-2); X is H, CL, F, Br, I, CF3, C1-6 alkyl; Y is H, CF3, F, Cl, CH3; R1 is α-H or absent; R2 is H, CH3 or absent; R3 is α-H, α-OH...
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JPH02215795A |
NEW MATERIAL: The compound of the formula I (ring A contains two or less double bonds; no adjacent double bonds exist in rings A-C; no double bond exists between 16C and 17C atoms in ring D when R has two substituents or a divalent subst...
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JPH0234958B2 |
Novel 19-nor steroids and 19-nor-D-homo-steroids of the formula I' wherein R1 is an organic radical of 1 to 18 carbon atoms containing at least one atom selected from the group consisting of nitrogen, phosphorous and silicon with the ato...
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JPH02111787A |
NEW MATERIAL: A compd. represented by formula 1 [wherein R1 is H or methyl; R2 is H, cyanide, heteroaryl, (substd.) 1-20C alkyl, OR3 (wherein R3 is H or 1-8C alkyl), SR2, etc.; A is α-hydroxyl and B is H provided they may combine with e...
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JPH0213678B2 |
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JPH0212479B2 |
Steroid compounds of the 20-spiroxane series and their analogues having an open ring E of the formula, (I) in which -A-A- represents the group -CH2-CH2- or -CH=CH-, R1 represents hydrogen, and R2 represents an alpha -oriented lower alkox...
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JPH0212237B2 |
D-Homo-4,17-androstadien-3-one is a pharmacologically effective compound having antiandrogenic activity upon topical application. The compound can be prepared from D-homo-5,17-androstadien-3 beta -ol by oxidation with simultaneous isomer...
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JPH0155277B2 |
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JPH0150240B2 |
1. D-homocorticoids of general formula I see diagramm : EP0049783,P5,F2 wherein the bond _._._. is a single or double bond, Q is oxygen or sulphur, X is hydrogen, fluorine or chlorine, R1 is hydrogen or a lower alkyl group, and Y is fluo...
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JPH0150206B2 |
Aromatase-inhibitors are used in a method of prophylaxis and/or treatment by therapy of prostatic hyperplasia. Pharmaceutical preparations suitable for such a use comprise an aromatase-inhibitor. A particularly preferred aromatase-inhibi...
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JPH0150207B2 |
A combination of an aromatase-inhibitor and an antiandrogen in a weight ratio of aromatase-inhibitor to antiandrogen of 20:1 to 1:1 is useful in a method of prophylaxis and/or of treatment by therapy of prostatic hyperplasia. The aromata...
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JPH01252298A |
NEW MATERIAL:A compound expressed by formula I [R1 is H or acyl; R2 is H or expressed by formula II (R4WR7 is R1); R3 is (protected) carboxy]. EXAMPLE: A compound expressed by formula III. USE: Antibacterial agent. Preventive and remedy ...
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JPH0134205B2 |
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JPH0122278B2 |
17 alpha -hyroxy- and 17a alpha -hydroxy-D-homoetiocarboxylic acids of the formula wherein n is 1 or 2, A is and R1 is H or CH3 are prepared by hydrating the corresponding 17-nitriles with a mixture of a lower carboxylic acid and its anh...
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JPS6475500A |
PURPOSE: To obtain the titled compound useful as a plant growth promoting substance, by reacting specific steroids with a peracid in an inert solvent containing an acid. CONSTITUTION: Steroids [e.g. (22R,23R,24R)-22,23-dihydroxy-2α,3α-...
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JPS646752B2 |
New alpha -glycosyl glycyrrhizins bearing two or more alpha -glucose residues are prepared. Such alpha -glycosylation is carried out by subjecting an aqueous solution of glycyrrhizin (or a salt thereof) and an amylaceous substance (e.g. ...
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JPS6356235B2 |
A process for preparing a 6-methylene- DELTA 4-3-keto steroid of the formula wherein R is hydrogen, alkoxy of up to 6 carbon atoms or acyloxy of up to 6 carbon atoms wherein the acyl group is that of a carboxylic acid, and R' is the CD-r...
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JPS63502878A |
(57) [Abstract] Since this gazette is application data in front of an electronic application, the data of an abstract is not recorded.
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JPS6352640B2 |
A process for preparing an 11-keto steroid consists essentially of heating the corresponding 9 alpha -halo-11 beta -hydroxy steroid, to 180 DEG -350 DEG C. in an inert, aprotic, high-boiling solvent.
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JPS63201197A |
11 beta -substituted steroids of the formula wherein A and B together represent a second bond between the 6-position and 7-position carbon atoms, or, respectively, are each H; X is O, two H atoms or hydroximino; Z is the residue of a pen...
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JPS6328885B2 |
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JPS6259099B2 |
3 beta -Hydroxy-18 beta -olean-9-en-30-oic acids having anti-ulcer activity of the formula (I) compositions containing the same and process for their preparation.
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JPS6251278B2 |
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JPS6247200B2 |
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JPS6234040B2 |
Corticoid-21-sulphopropionate derivs. of formula (I) and their salts with pharmaceutically-acceptable bases are new: (St = steroid residue of an antiinflammatory corticoid; esp. it has formula (X = H, Cl, F or CH3; Y = H, F or Cl; Z = ox...
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JPS6227076B2 |
1. A process for the preparation of a 17 alpha-(3-iodobenzoyloxy)-9 alpha-chloro-4-pregnene-3,20-dione or a D-homo homolog thereof of the formula I see diagramm : EP0001737,P9,F2 wherein n is 0 or 1 ; C1 ~-~-~- C2 represents a C-C single...
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JPS6221765B2 |
Roentgenologically amorphous escin and processes for its preparation are provided. The amorphous escin is much more soluble in water than crystalline escin, and this facilitates its employment in pharmaceutical compositions in place of c...
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JPS6217598B2 |
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JPS6213927B2 |
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JPS6212765B2 |
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JPS6226296A |
NEW MATERIAL:The compound of formula [R1 is formyl or H; R2 is formyl or carboxyl; X is -C(OR3)- (R3 is lower alkylacyl or H) or carbonyl]. EXAMPLE: 12-Acetyl-20-methyl-20-oxoscala-16-ene-19,23-dial. USE: An easily administrable remedy f...
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JPS6160839B2 |
D-Homopregnanes of the formula wherein X is hydrogen, Y is hydroxy or X and Y taken together denote an oxygen to carbon bond; R6 is hydrogen, R7 is hydrogen, lower alkanoylthio or aroylthio, or R6 and R7 taken together denote a carbon to...
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JPS6157320B2 |
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JPS61502186A |
Novel compounds having the general formula (I), wherein: R<1> is hydrogen or an acyl substitutent of formula -(C=O)-R<2>, wherein: R<2> is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkylene, haloalkyl, aryl, haloaryl or arylalkyl...
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JPS6118536B2 |
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JPS6185344A |
NEW MATERIAL:A compound shown by the formula I [R1 is OH, or group shown by the formula II (R6 is H, or alkanoyl; R7 is H, or alkayl), alkoxy, etc.; R2 is hydroxymethyl, alkanoyloxymethyl, etc.; R3 is H, OH, or oxo; R4 and R5 are formyl,...
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JPS611440B2 |
The present disclosure relates to novel D-homo-pregnene steroids useful as progestational agents.
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JPS615092A |
The 6 alpha -methyl-D-homo-corticoids have the general formula (I) in which the bond .... represents a single bond or a double bond and X is a hydrogen atom, a fluorine atom, a chlorine atom or a bromine atom, Z is a hydrogen atom or, to...
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JPS6052160B2 |
1365469 D-homosteroids F HOFFMANNLA ROCHE & CO AG 29 March 1973 [29 March 1972] 15112/73 Headings C2U and C2C The invention comprises compounds of formula (wherein R6 is H, F, Cl or Me; R9 is H, F, Cl or Br; and R17 and R21 are each hydr...
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JPS6050800B2 |
The present disclosure relates to steroid carboxylic acids and derivatives thereof. More particularly, the disclosure is concerned with D-homosteroid carboxylic acids and their derivatives, a process for the preparation thereof and pharm...
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