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WO/2004/064784A2 |
The present invention provides multiple antigenic agents compositions and the use thereof to prevent or treat viral infections.
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WO/2004/065928A2 |
The present invention involves a method of coupling disulfide bridge containing proteins to a carrier by inducing the formation of thiol groups on a protein with irradiation, and coupling the protein to the carrier. The formation of thio...
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WO/2004/063719A2 |
The present invention relates to automated methods, systems, and apparatuses protein separation and analysis. In particular, the present invention provides an automated system for the separation, identification, and characterization of p...
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WO/2004/060041A2 |
The use of KIM-1 antagonists to inhibit signaling between a T cell and a second cell, e.g., an antigen-presenting cell, is disclosed. Such inhibition is useful for treatment of diseases including various autoimmune diseases and graft-ver...
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WO/2004/060304A2 |
The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present inv...
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WO/2004/058946A2 |
The invention provides proteins attached to solid supports, and methods of preparing such solid support-bound proteins are provided. The proteins are attached to solid supports by means of an unnatural amino acid incorporated into the pr...
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WO/2004/058188A2 |
Methods of enhancing antigenic presentation or increasing immunogenicity of a polypeptide by modifying the three dimensional structure of a polypeptide.
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WO/2004/058953A1 |
This invention provides a method for identifying a compound capable of inhibiting the binding of HCV to a cell expressing a surface receptor selected from the group consisting of DC-SIGN or DC-SIGNR comprising: (a) contacting the cell ex...
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WO/2004/056970A2 |
The invention provides a method for mapping the location of the post-translational modifications of a post-translationally modified peptide. Also provided is a solid-phase support that includes a reagent for modifying a post-translationa...
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WO/2004/056309A2 |
Activated protein C (APC), prodrug, and/or a variant thereof may be used as an inhibitor of apoptosis or cell death and/or a cell survival factor, especially for stressed or injured cells or tissues of the nervous system including subjec...
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WO/2004/052273A2 |
The present invention is characterized by the process of preparation of pharmaceutical compositions for the development of applications of the Evasins and their structural and/or conformational analogues in chronic-degenerative diseases....
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WO/2004/047762A2 |
The present invention relates generally to cancer treatment, prophylaxis, and detection, and more specifically, to Porimin binding partners and methods for using Porimin as a target for the treatment, prophylaxis and/or detection of canc...
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WO/2004/047746A2 |
The invention relates to the regulation of stearoyl-CoA desaturase to treat obesity, methods for assessing stearoyl-CoA desaturase activity, and methods of identifying compounds for the treatment of obesity and obesity-related disorders....
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WO/2004/048512A2 |
The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, ...
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WO/2004/046365A2 |
The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells contai...
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WO/2004/044006A1 |
Conjugate comprising an interleukin-10 (IL-10) polypeptide and a polymer. The IL-10 has at least one cyteine residue introduced (by substitution) in a position selected form 89 positions. The polymer (e.g. PEG) is attached to cysteine re...
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WO/2004/043141A2 |
The present invention provides novel compositions of matter comprising MAP compositions comprising at least 2 inhibin-related peptides linked to a backbone. These compositions are immunogenic and enhance production performance when admin...
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WO/2004/044573A1 |
A device and method are presented for detecting analyte molecules in a medium. At least one FET (Field Effect Transistor) is provided being formed by at least one pair of source-drain electrodes and at least one gate electrode. The gate ...
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WO/2004/043386A2 |
The present invention is based, at least in part, on the discovery of certain genes which are absent from T regulatory cells and present on effector T cells (Th1 and Th2), e.g., Protein Kinase C Theta (PKC theta). Furthermore, a pathway ...
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WO/2004/042060A1 |
The present invention relates to a polypeptide tag and a method using said polypeptide tag sequence for immobilising a protein on a microporous material, said microporous material is selected from the group consisting of zeolite or simil...
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WO/2004/037847A2 |
Env-CD4 complexes and hybrids are disclosed that expose cryptic epitopes that are important in virus neutralization. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.
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WO/2004/038402A1 |
The present invention provides a method of depositing an analyte of interest on a hydrophobic surface, e.g., DIOS-MS substrates, by desolvating organic solvents from the aqueous analyte solution prior to deposition.
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WO2002092788A9 |
In accordance with the present invention, it has been discovered that the beta -amyloid precursor protein (APP), and two APP-like proteins (APLP1 and APLP2) are proteolytically cleaved by caspases in the C terminus to generate an approxi...
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WO/2004/036011A2 |
This invention relates to actuators having biologically-based components, and methods of making and using the same. The actuator of the invention has a movable member that moves substantially linearly as a result of a biomolecular intera...
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WO/2004/032839A2 |
Novel compounds, pharmaceutical compositions, and methods are provided for modulating processes mediated by nuclear hormone receptors. A partial or complete agonist or antagonist modulates, directly or indirectly, an activity of one or m...
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WO/2004/031381A1 |
It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohorns or carbon nanotubes, an art...
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WO/2004/028473A2 |
A method for preventing infection of helper T and other target cells by human immunodeficiency virus type 1 ('HIV-1') and for preventing or treating acquired immunodeficiency syndrome ('AIDS') by exposing target cells to a synergistic co...
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WO/2004/024761A1 |
The present invention relates to hydroxyalkylstarch (HAS)-polypeptide-conjugate (HAS-polypeptide) comprising one or more HAS molecules, wherein each HAS is conjugated to the polypeptide via a carbohydrate moiety or a thioether as well as...
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WO/2004/024777A1 |
The present invention relates to a method of producing a hydroxyalkyl starch derivative comprising reacting hydroxyalkyl starch of formula (I) at its reducing end which is not oxidized prior to said reaction, with a compound of formula (...
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WO/2004/024776A1 |
The present invention relates to a method of producing a hydroxyalkyl starch derivative, said hydroxyalkyl starch having a structure according to formula (I) comprising reacting - hydroxyalkyl starch o formula (I) at its optionally oxidi...
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WO/2004/022630A2 |
The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanal...
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WO/2004/019967A1 |
The invention provides a method for isolating and identifying proteins participating in protein-protein interactions in a complex mixture. The method uses a chemically reactive supporting matrix to isolate proteins that in turn non-coval...
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WO/2004/018997A2 |
Provided herein are methods and compositions for detecting, assessing and modulating β-amyloid peptide (Aβ) levels and/or processing of amyloid precursor protein. Methods for screening and/or identifying agents that modulate processing...
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WO/2004/016769A2 |
Embodiments of the invention described herein relate to antibodies directed to the antigen monocyte chemo-attractant protein-1 (MCP-1) and uses of such antibodies. In particular, in accordance with some embodiments, there are provided fu...
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WO/2004/013160A2 |
Disclosed are compositions for chimeric proteins comprising a protein transduction domain and a deaminase domain, mimetics or analog thereof, and uses of same.
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WO/2004/010939A2 |
The invention provides methods and compositions for treating disorders using non-human animal Apolipoprotein A-I (ApoA-I) protein. The invention provides methods and compositions for treating disorders in animals, including humans, assoc...
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WO/2004/006756A2 |
The present invention provides methods for the treatment, and pharmaceuticals for the use in the treatment, of mammalian subjects having, or at risk of developing, glomerulonephritis or chronic renal failure. The methods involve the admi...
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WO/2004/007661A2 |
The present invention provides methods of assembling oligopeptides or polypeptides in a native chemical ligation reaction that eliminates the formation of unwanted side products resulting from the presence of an unprotecte acidic C-termi...
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WO/2004/007679A2 |
A molecule capable of potentiating immune responses is described, as well as methods for using the molecule to enhance immune responses and enhance dendritic cell function. Also described are compositions containing the molecule and meth...
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WO/2004/006951A1 |
Platforms comprising at least one lymphocyte affecting molecule and at least one molecular complex that, when bound to an antigen, engages a unique clonotype lymphocyte receptor can be used to induce and expand therapeutically useful num...
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WO/2004/005319A2 |
Provided are peptidomimetic protein-binding arrays, their manufacture, use, and application. The protein-binding array elements of the invention include a peptidomimetic segment linked to a solid support via a stable anchor. The inventio...
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WO/2004/004768A1 |
The invention relates to microparticles with a support structure and CD28-specific superagonistic monclonal antibodies (rAb) bonded to the support structure or a compound mimicking the above.
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WO/2004/004455A2 |
The invention relates to general biotechnology and, in particular to compositions and methods for stabilising or preserving biological molecules and to devices which produce the thus stabilised molecules.
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WO/2004/005477A2 |
Provided are protein microarrays, their manufacture, use, and application. Protein microarrays in accordance with the present invention are useful in a variety preoteomic analyses. Various protein arrays in accordance with the present in...
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WO/2004/002431A2 |
This invention concerns humanized antibodies specific for the lymphotoxin beta receptor (LT-β-R), cell lines that produce these antibodies, immunochemicals made from the antibodies, and diagnostic methods that use the antibodies. The in...
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WO/2003/106487A1 |
The invention relates to an immunogenic conjugate comprising at least one vascular endothelial growth factor (VEGF) peptide moiety coupled to a carrier.
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WO2003037172A9 |
The present invention relates to peptides and their derivatives which bind to endothelial cells and inhibit their proliferation in in vitro assays, e.g., also referred to herein as endothelial cell binding peptide (ECBP) or ECBP sequence...
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WO/2003/099465A1 |
Methods for forming repeat protein polymers and utilizing the repeat protein polymers to form inorganic structures are provided. The inorganic structures may have features on the nanoscale, and the structures generally do not have the re...
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WO/2003/099855A1 |
The invention relates to a device for the presentation of polypeptides, a method for the preparation and the use thereof, as diagnostic tool (polypeptide chip) for miniaturized and highly parallel detection of structurally or functionall...
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WO/2003/097672A1 |
A method for controlling an embeded protein (including peptide) by photic stimulation, characterized in that it comprises a step of modifying nano particles comprising a hydrophilic polymer with a light-respondent compound (a compound un...
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