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WO/2003/097699A1 |
Methods and compositions for the immobilization of glycoproteins are presented herein. In addition, the present invention provides arrays of immobilized glycoproteins. The methods of immobilizing glycoproteins include oxidation of the gl...
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WO/2003/098214A1 |
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vac...
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WO/2003/094961A1 |
The present invention concerns a purification process for polysaccharide antigens involving the removal of contaminating endotoxin by affinity-binding of the lipid A moiety of LPS with synthetic anti-endotoxin peptides (SAEP), which resu...
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WO/2003/094959A1 |
The present invention concerns a conjugation process for coupling a endotoxin (LPS) free polyfunctional polysaccharide with a polyfunctional carrier protein with quantitative yields. The invention also provides for vaccine formulations c...
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WO/2003/095494A1 |
The present invention relates to a surface discovery system comprising chemical compositions and high-throughput combinatorial synthesis methods for generating large numbers of diverse surface coatings on solid substrates. This surface d...
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WO/2003/089900A2 |
The present inventionprovides methods and compositions for orientation and covalent immobilization of protein on a surface, e,g., using light-mediated and/or oxidative reaction chemistry between functional groups on the surface and parti...
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WO2002044336B1 |
A polymer is prepared by self-assembly of a plurality of monomeric polypeptide units. The polymer tends to form a nanotube and is capable of encapsulating a particular drug molecule. Once encapsulated in the polymer of the present invent...
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WO/2003/086444A1 |
The present invention provides a means for increasing the serum half-life of a selected biologically active agent by utilizing transthyretin (TTR) as a fusion partner with a biologically active agent. Specifically, the present invention ...
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WO/2003/085375A2 |
The present invention relates to a cell-based HTS assay for evaluation of antiviral activity of compounds against HCV using HCV replicon.
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WO/2003/084982A2 |
The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel ...
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WO/2003/080653A1 |
Novel peptide having a sequence according to SEQ. ID. No.1, SEQ. ID. No. 2 and/or SEQ. ID. No. 3 are disclosed and also polypeptide scaffold consisting of a four helix bundle formed of two dimerized helix-loop-helix motifs, said helix-lo...
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WO/2003/078454A2 |
There is provided a method for the purification of bio-molecules after chemical modification using one or more insoluble polymer supported reagents. More particularly, the present invention provides a method for the fast purification of ...
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WO2002020769A9 |
The present invention concerns methods and compositions for in vivo and in vitro targeting. A large number of targeting peptides directed towards human organs, tissues or cell types are disclosed. The peptides are of use for targeted del...
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WO/2003/072709A2 |
Variants of the HIV-1 Tat protein exhibiting higher transcriptional activation and stronger P-TEFb binding than wild-type Tat are provided. In addition variants that can inhibit transcription activation by wild-type Tat are provided. Nuc...
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WO2002032943A9 |
Modified HIV Env, Gag, Pol, or Nef DNA with improved ability to elicit antibody and CTL responses to HIV antigens have been identified as prototype immunogens for the treatment and prevention of HIV infections.
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WO2002044327A9 |
A method and apparatus for extracting, identifying, and manipulating proteins or peptides from a solution uses paramagnetic beads having a coating with an affinity for the target component. In one embodiment, paramagnetic beads coated wi...
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WO/2003/068806A1 |
A method for peptide synthesis is described, comprising steps of forming an organofunctional silica by reaction of an alkyl silicate, an organofunctional silane and water, optionally in the presence of a template compound; removing the t...
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WO/2003/066090A1 |
A process is disclosed for preparation of a immunogenic peptide mixture in a single synthesis. The peptide mixture collectively represents the in vivo variability seen in immunogenic epitopes from a pathogen. The mixture is termed a hype...
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WO/2003/066892A1 |
The present invention relates to a polymorphic TPMT polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or ...
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WO/2003/067219A2 |
The present invention relates to structure-based methods for identifying molecules which will bind to the &agr A-lacking integrin &agr Vβ3 receptor extracellular domain and modulate function, e.g., by acting as receptor agonists, such a...
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WO/2003/066660A2 |
Compositions and methods using antiparallel heterogeneous &agr -helical coiled-coil (AHEC) regions for the linkage and stabilization of antibody Fv domains are provided. The AHEC peptides may be derived from repeat domains of the spectri...
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WO/2003/064604A2 |
Surface-bound, translationally competent ribosome complexes are used to generate a translation profile for mRNA, which mRNA may be a single molecular species, or a combination of species, including complex mixtures such as those found in...
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WO/2003/065040A1 |
A nucleic acid is fixed to a carrier made of a synthetic resin (for example, polycarbonate, polymethyl methacrylate, acrylonitrile-butadiene-styrene copolymer, polyethylene, polyethylene terephthalate, polyphenol, polystyrene, polyacrylo...
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WO/2003/059385A2 |
This invention is directed to pharmaceutical compositions comprising an HIV antigen and a mucosal adjuvant and methods for raising an immune response in a subject by administering these compositions. Preferably, the pharmaceutical compos...
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WO/2003/060473A2 |
An in vitro high−throughput screening method that models the absorption of drugs across the epithelial mucosa is provided. The invention discloses an in vitro mucin immobilized chromatography model to estimate drug permeability coeffic...
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WO/2003/057734A1 |
The invention is directed to entrapped binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrices, and their use as analyte bio...
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WO/2003/055916A2 |
The invention relates to a conjugate comprising an adiponectin polypeptide, and a first non-polypeptide moiety covalently attached to the adiponectin polypeptide, wherein the adiponectin polypeptide comprises an amino acid residue having...
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WO/2003/055980A2 |
Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vestors, hot cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for th...
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WO/2003/051910A2 |
The present invention features HCV protease inhibitors, which act by affecting the activity of the HCV protease NS3, or by preventing its activation by NS4A. The invention also features methods of use of the inhibitors of the invention i...
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WO/2003/049760A1 |
The present invention provides compositions and methods of treating hepatitis virus infection, particularly hepatitis C virus infection. The invention provides methods of treating a hepatitis virus infection, involving administering a fi...
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WO/2003/050544A2 |
The invention relates to a method allowing identification and/or quantifying and/or characterizing proteins in a protein mixture, wherein the proteins are stratified on feature(s) on an array, and a procedure, preferably mass spectrometr...
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WO/2003/045980A2 |
This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the glycopeptides have a homogeneous glycosylatio...
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WO/2003/045975A2 |
Disclosed herein are methods for immobilizing a peptide or protein on a solid support. The method generally includes the following steps: (a) providing one or more templates attached to a solid support, wherein the one or more templates ...
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WO/2003/044056A2 |
The present invention provides a chemically modified human Growth Hormone (hGH) prepared by binding a water soluble polymer to the protein. The chemically-modified protein according to the present invention may have a much longer lasting...
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WO/2003/040726A2 |
The present invention features methods of screening for compounds that inhibit HCV binding to a cell, methods of inhibiting HCV entry into a cell, and methods of actively or prophylactically treating against an HCV infection. The differe...
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WO/2003/038033A2 |
Ultrahigh resolution patterning, preferably carried out by dip-pen nanolithographic printing, can be used to construct peptide and protein nanoarrays with nanometer-level dimensions. The peptide and protein nanoarrays, for example, exhib...
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WO/2003/033672A2 |
The invention relates to the identification of a new mouse gene and its trancript that encode a new NR3B subunit of NMDA receptors.
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WO/2003/033539A1 |
The invention relates to molecular biology and bioorganic chemistry, more specifically to a composition for mobilising, in polymeric carriers, oligonucleotides, proteins, nucleonic acids and other molecules which contain active groups in...
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WO/2003/031466A2 |
The present invention provides conjugates of peptide derivatives of the mammalian peptide hormones angiotensinogen, angiotensin I and angiotensin II, presented in a repetitive scaffold by coupling the peptide derivatives to a carrier, pa...
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WO/2003/029436A2 |
ULBP4, a novel member of the ULBP family has been isolated and characterized. ULBP4 is a useful activator of immune effector cells, particularly of NK cells.
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WO/2003/025011A1 |
It is intended to provide an adsorbent, an adsorption unit and an adsorption method whereby immunoglobulin and&sol or an immune complex contained in a body fluid (blood, plasma, etc.) can be efficiently and selectively adsorbed without a...
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WO/2003/020298A1 |
The present invention relates to optimal compositions useful in treating HCV infections in humans. These compositions comprise alpha-interferon or a derivative thereof and an IMPDH inhibitor, wherein the IMPDH inhibitor is present in an ...
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WO/2003/020320A2 |
The invention relates to nanoparticles comprising tumour necrosis factor (TNF) or cytokine, immobilised thereon, the TNF or cytokine preferably being oriented in the form of a trimer and being immobilised on the carrier while maintaining...
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WO/2003/018636A2 |
The invention relates generally to chimeric peptides and compositions that facilitate the transport of insulin across biological membranes, methods for preparing the chimeric peptides, and a method for treating a subject suffering from d...
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WO/2003/018854A2 |
The present invention provides an article for immobilizing functional organic biomolecules through a covalent bond to a thiolate monolayer on a coinage metal surface. Also provided are methods for making the article and methods for the i...
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WO/2003/012127A2 |
A method for measuring heterodimerization of HIV RT, which comprises the steps of:a) providing a first solution comprising p66 subunit homodimers in the presence of a dissociation agent; b) contacting the first solution with p51 RT subun...
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WO/2003/011118A2 |
Reagents, methods, and kits are described that are useful for fertility testing and that in many cases provides much faster, convenient and rapid determination of male infertility. The reagents described include properly glycosylated hum...
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WO2002032925A9 |
Disclosed herein are proteins that include an immunoglobulin fold and that can be used as scaffolds. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evo...
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WO/2003/010203A1 |
The invention relates to molecular biology and bioorrganic chemistry and concerns compositions for immobilising modified oligonucleotides, proteins, nucleic acids and any other molecules carrying unsaturated groups in a hydrogel for prod...
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WO/2003/008453A1 |
The present invention relates to immobilization of fusion proteins to surfaces. According to this invention a fusion polypeptide comprises an adhesion polypeptide fused to a preselected polypeptide. Specifically the method takes advantag...
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