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WO/2003/004517A2 |
Purified synthetic polypeptide ligands for targeting pharmaceutical agents and carriers comprising such agents to intestinal epithetial tissue, especially Peyer's patch and/or M-Cell tissue. Also methods of using the ligands.
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WO/2003/000733A2 |
Glycopeptides capable of identifying multiple sclerosis antibodies, and therefore useful as diagnostic tools or for the treatment of said pathology are described.
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WO/2003/000234A1 |
An open porous matrix of particulate material for in vivo use in or on a target tissue in medicine, the matrix comprising particles cross-linked with one another so as to define pores there between and uses therefor are described.
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WO2001079300A9 |
The instant invention provides compositions for downmodulation or upmodulation of the immune response. For example, constructs comprising an exposed surface having attached to it i) an antigen-binding portion of an antibody that binds to...
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WO/2002/099099A2 |
The present invention relates to a polymorphic CYP2C8-polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide o...
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WO/2002/097051A2 |
Methods of rapidly generating and analyzing a plurality of polypeptides are disclosed. More specifically, libraries and arrays of polypeptides are assayed in order to determine their individual immunogenic effect. Based on the immunogeni...
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WO/2002/097118A1 |
A layer of cell surface layer proteins (S layer proteins) (SU, SM, SL) as carrier of functional molecules is produced on a carrier surface (CP) by bringing into contact an S layer protein in the form of a solution containing monomers (SU...
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WO2002062957A9 |
The present invention provides materials and methods for the utilization of the specific interaction of replication termination sequences with their binding proteins in molecular biology applications.
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WO/2002/095075A1 |
A menu of mutations was developed that is useful in fine-tuning the attenuation and growth characteristics of dengue virus vaccines.
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WO/2002/094029A1 |
The present invention provides a method of inhibiting fungal growth on a growing plant of agricultural or horticultural origin. In a preferred embodiment, an effective amount of a fungal growth inhibiting composition comprising a peptide...
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WO/2002/092615A2 |
The invention provides biological molecules modified by reaction with a compound having the formula (I): R¿1?-X-R¿2?, wherein R¿1? is a cyclic ether group or an amino group, R¿2? is an alkoxysilane group and X is a moiety chemically ...
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WO/2002/085926A2 |
The invention relates to a method for producing stable, regeneratable antibody arrays, using immobilised antibody binding proteins which are able to specifically identify the Fc part of antibodies.
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WO/2002/086503A1 |
It is intended to provide novel lipopolysaccharide adsorbents (bacteriotoxin adsorbents) which can be easily synthesized and modified into various analogous structures and are usable in adsorbing various lipopolysaccharides and a method ...
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WO/2002/085519A2 |
Compositions are provided herein comprising a base material having engrafted polymer brusches. The polymer brushes further comprise one or more functional groups immobilized along the surface of the brushes in a plurality of layers, whic...
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WO/2002/083916A2 |
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WO/2002/083928A2 |
A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein l58P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Cons...
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WO/2002/083872A2 |
Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and ...
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WO/2002/083917A2 |
A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Cons...
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WO/2002/083933A2 |
The invention relates to a method for determining the substrate specificity of an enzymatic activity comprising the following steps: preparation of an assembly comprising a plurality of amino acid sequences on a planar surface of a suppo...
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WO/2002/081683A2 |
A method of forming an array of proteins selected from antigens or antibodies; said method comprising the steps of (i) expressing in a recombinant cell, a fusion protein which ocmprises either (a) an antigen or (b) an antibody binding pr...
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WO/2002/081637A2 |
Molecules having potential biological activity, particularly peptoids, that are conjugated to solid phase supports, spacer groups, and/or ligation moieties, and methods of their preparation, are described. In some instances, the molecule...
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WO/2002/081753A1 |
Methods are provided that facilitate the identification and characterization of individual nucleic acid molecules.
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WO/2002/079232A2 |
Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to ...
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WO/2002/079397A2 |
The invention is directed to peptides having antimicrobial activity (antimicrobial peptides). The antimicrobial peptides of the present invention are analogs of the Lentivirus Lytic Peptide 1 (LLP1) amino acid sequence. The invention is ...
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WO/2002/079415A2 |
Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to ...
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WO/2002/076485A2 |
The present invention provides liposomal vaccines containing immunogenic lipopeptides that are capable of modulating the humoral and cellular immune responses in in vivo.
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WO/2002/076489A1 |
Compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum albumin molecules in a solution, for blood circulation imaging, an...
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WO/2002/074950A1 |
It is intended to provide a method of quickly and quantitatively measuring an interaction between a protein, a nucleic acid, a sugar chain or a physiologically active molecule and a target molecule. Thus, a protein labeled at the C-end b...
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WO/2002/074797A2 |
The invention relates to a protein having multiple antigen&sol epitope sequences for antibodies, wherein the protein is immobilized at a solid phase by at least one binding site, and the antigen&sol epitope sequences are spaced by bridge...
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WO/2002/072865A2 |
This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions.
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WO2001036630A9 |
The invention relates to a novel compound termed NKp30 that is selectively expressed by all mature NK cells and that is involved in human natural cytotoxicity as an activatory receptor, to new antibodies that bind to the NKp30 structure,...
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WO/2002/072631A2 |
Novel compounds carrying ligands capable of ligating to counter receptors on relevant target cells are disclosed. The compounds possess a number of advantageous features, rendering them very suitable for a wide range of applications, inc...
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WO2001013937A9 |
The present invention relates to peptides capable of modulating the function (e.g., signaling or adhesive activities) of CD66 (CEACAM) family members and/or their ligands.
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WO/2002/066984A2 |
The invention relates to the detection of biomolecules or analogs thereof in micro-arrays and the supports used for said micro-arrays, in particular in methods for determining or testing binding of a first member molecule within an array...
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WO/2002/066056A2 |
The present invention provides for novel immungens that are comprised of an activated polyhydroxypolymer backbone to which is attached 2 separate antigenic determinants. The 1st antigenic determinant includes a B-cell or CTL epitope and ...
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WO/2002/066511A2 |
This invention relates to glucagon-like peptide 2(GLP-2) derivatives. In particular, this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders ...
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WO2000033865A9 |
The invention provides a method of inhibiting ectopic calcification in an individual. The method consists of administratering to the invidual a therapeutically effective amount of osteopontin or a functional fragment thereof. The inventi...
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WO/2002/062846A2 |
The field of the invention relates in general to at least one method and apparatus for the production of soluble MHC antigens and more particularly, but not by way of limitation, to at least one method and apparatus for the production of...
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WO/2002/060937A1 |
The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit ...
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WO2001034635A9 |
The present invention relates, first, to methods for the synthesis of peptides referred to as T-1249 and T-1249-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific ...
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WO/2002/055561A1 |
The present invention relates to methods for preparing a protein of interest surface-displayed on genetic carrier, for improving a protein of interest, for isolating a substance of interest, bioconversion and producing antibody. More par...
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WO/2002/051856A2 |
The invention concerns a solid support comprising sites designed to immobilise oligonucleotide probes or proteins or biological cells provided with ligands, the sites being provided with species bound to the support by a chemical binding...
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WO/2002/051917A1 |
The invention relates to a novel surface-functionalised carrier material comprising a polymer surface and at least one linker compound according to general formula (I), which is bonded to said surface in a covalent manner. In formula (I)...
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WO/2002/051872A1 |
The invention relates to a method for immobilising biomolecules on a polymer surface of a carrier material, and a carrier material which is functionalised by a biomolecule, according to general formulae (IV) and (V), and which can be pro...
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WO/2002/050171A1 |
The present invention relates generally to a grafting process comprising the formation of a grafted polymeric structure having a substrate polymer in hybrid formation with one or more of the same or other polymers or monomeric subunits t...
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WO2000056774A9 |
Bioelastomers are disclosed for use in methods of binding compounds including immunoassay methods, in biosensors and methods or regenerating biosensors, and in methods for targeting the delivery of a compound to a particular location wit...
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WO/2002/048193A2 |
Protein arrays are provided comprising single domain antibodies obtainable from Camelidae which are capable of detecting even minor changes in the expression of proteins in cell and tissue extracts and having an optimal signal to noise r...
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WO/2002/042321A2 |
Fibrils of two or more different peptides are disclosed; these peptides can be related or unrelated. They have a variety of uses as biomaterials and nanomaterials.
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WO/2002/034915A2 |
The invention is directed to preferred repeat sequences of Neural Thread Protein (NTP), peptides, mimetics, antibodies, and nucleic acids of the preferred sequences, and diagnostic and therapeutic methods of using such preferred NTP sequ...
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WO/2002/032963A1 |
This invention relates to compounds of general formula I, in which S is a carbohydrate core matrix; a is a pharmaceutically active moiety; L is a linker a covalent bond; n is an integer of 2 to 19; and R' is hydrogen, thioalkyl or X-Z in...
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