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JP2003533189A |
The present invention relates to the fields of biology and computer sciences. The present invention provides proteinaceous molecules to encode solutions to computational problems. In one aspect the invention provides the use of a protein...
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JP2003310259A |
To provide a method for cyclopaedically and efficiently cloning a nuclear protein group and a nuclear protein cDNA group each having a transcription function.In the method for cyclopaedically cloning the cDNA of the nuclear protein havin...
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JP2003299489A |
To provide a technique useful in refining in vitro virus virion on the mRNA side through tagging an in vitro virus genome without making any troublesome manipulation and also useful in preparing protein chips by immobilizing an mRNA onto...
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JP2003529609A |
Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having a...
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JP2003267991A |
To provide a material and a method enabling an organic compound to be analyzed in high accuracy.The organic compound contains the main stable isotope of at least one element among the constituent elements in a ratio higher than its natur...
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JP2003527819A |
A novel procathepsin K crystalline structure is identified. Also disclosed are methods of identifying inhibitors of cathepsin K and methods of designing inhibitors of cathepsin K using structural and physical data based on the crystallog...
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JP3446979B2 |
PURPOSE: To obtain a water-soluble hair-dressing agent containing a silylated peptide, capable of preventing the hair, imparting luster, moisture and tension to the hair, preventing the branching of the hair, improving the combing proper...
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JP2003245073A |
To provide a method of producing random polynucleotides.Disclosed is a method of producing random polynucleotides by introducing two or more related polynucleotides into a suitable host cell such that a hybrid polynucleotide is generated...
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JP2003246800A |
To provide a method for easily producing a lactone in a high yield from a sialic acid compound contained in a processed milk product, etc.This method for producing a lactone of a sialic acid compound comprises separating a fraction havin...
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JP2003522621A |
The invention refers to a new process for preparing coated particles and hollow shells by coating colloidal particles with alternating layers of oppositely charged nanoparticles and polyelectrolytes and optionally removing the colloidal ...
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JP2003522182A |
The invention relates to a method of stabilizing a hydrophobin-containing solution. According to the present invention, the hydrophobin is subjected to a treatment with a disulphide bridge-cleaving agent to yield unfolded hydrophobin, sa...
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JP2003521448A |
The present invention is directed to polypeptides and peptides containing at least three amino acids randomly joined in a linear array; wherein at least one of the three amino acids is an aromatic amino acid, at least one of the three am...
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JP3424752B2 |
PCT No. PCT/EP92/01072 Sec. 371 Date May 9, 1994 Sec. 102(e) Date May 9, 1994 PCT Filed Apr. 15, 1992 PCT Pub. No. WO92/21033 PCT Pub. Date Nov. 26, 1992The present invention concerns a method for the determination of allele-specific pep...
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JP2003176300A |
To solve a problem that a T-cell epitope is the center of a specific immune system on the basis of the central position of a three molecule complex comprising a T-cell receptor, a peptide and a MHC molecules, whereby there are many neces...
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JP3408271B2 |
PURPOSE: To obtain an aminated saccharide derivative useful for synthesizing a reduced end labeled saccharide and an artificial complex glucide by reducing a 2-aminopyridine derivative saccharide and decomposing the resultant compound un...
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JP2003515538A |
Novel C-132-COXR1, C-172-COXR2 and C-132-COXR1, C-172-COXR1 derivatives of chlorophyll and bacteriochlorophyll compounds are provided wherein X is O, S or N and R1 and R2, the same or different, may be an optionally substituted hydrocarb...
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JP3386210B2 |
PURPOSE: To efficiently prepare various peptides by expressing a peptide on the surface of a microorganism transformed with a vector containing a DNA capable of encoding the peptide, then screening the peptide with a peptide receptor and...
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JP3385572B2 |
PURPOSE: To safely and inexpensively isolate a CA 195-like substance useful for immunochemical assays or the like from a human amniotic fluid sample. CONSTITUTION: A suitable human amniotic fluid sample is selected by using an immunometr...
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JP2003504062A |
WO99/36544 discloses a large number of proteins from Neisseria meningitidis. The present invention relates to fragments of those proteins which comprise at least one antigenic determinant. Homologous sequences and proteins comprising the...
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JP2003501393A |
Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 ami...
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JP3366341B2 |
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JP2003000153A |
To provide a material effective in medicinal fields, healthy food fields, etc., by using Undaria pinnatifida as a raw material.This enzymic hydrolyzate of the Undaria pinnatifida is composed of a peptide mixture obtained by hydrolyzing t...
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JP2002542145A |
A method of facilitating vascular growth in a subject in need of such treatment comprises inhibiting EMAP II activity in the subject by an amount effective to stimulate vascular growth in the subject (e.g., in the lungs or heart of the s...
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JP2002540279A |
Compounds having the structure: W = Sq - A where A has the formula: -NR<1>R<2>, where R<1> and R<2> are the same or different and each is H or C1-C20 hydrocarbon or a group -L-G, or one of R<1> and R<2> is -OR<5> or -NR<6>R<7> or -COR<7>...
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JP2002536295A |
Method of making metallopeptides is provided, for use in biological, pharmaceutical and related applications. The metallopeptides are made of peptides, peptidomimetics and peptide-like constructs, and include a metal ion-binding region t...
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JP3339235B2 |
PURPOSE: To provide an antibiotic WAP-8294 A or its salts which has specific physical and chemical properties and is useful in treating MRSA (methicillin- resistant Staphylococcus aureus) infections. CONSTITUTION: This antibiotic, WAP-82...
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JP2002534082A |
The invention provides a microinsertion-based, trans-complementation method of in vitro oocyte activation useful to identify properties of sperm-borne oocyte-activating factor(s) (SOAF) and ooplasmic interactions with sperm components at...
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JP3334904B2 |
The invention relates to monoclonal antibodies (MAb) and the fragments thereof which have a specific affinity for the plasmin-antiplasmin complex and no, or only a very low, affinity for the individual components of these complexes, and ...
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JP3328277B2 |
By use of the Köhler/Milstein procedure involving immunization of mice with a number of different rough strains of heat-killed Gram-negative bacteria followed by fusion and suitable screening of the resulting hybridomas, murine monoclon...
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JP2002273218A |
To provide a capturing body which can be used suitably in various fields starting with a medical field, an industrial field and the like, has excellent biodegradability and safety and uniquely works on the subject to be captured to captu...
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JP3324611B2 |
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JP3306434B2 |
To obtain a monoclonal antibody capable of specifically detecting a stress-inducible type enzyme human hemoxygenase (human HO)-1 and suppressing the human HO-I activity without exhibiting cross-reactivity with a stress-noninducible type ...
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JP3306826B2 |
A method of inhibiting thrombin is disclosed, as well as a method of treating or preventing thrombosis and hypercoaguability. The methods employ compounds of the formula stereoisomers thereof and physiologically acceptable salts thereof.
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JP2002519430A |
The invention relates to peptide derivatives that can be used as selective inhibitors of the N-terminal site of human angiotensin-converting enzyme.The derivatives comprise the amino acid sequence with the following formula:wherein:Ψ(PO...
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JP2002517459A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002517442A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002517458A |
(57) [Summary] Methods for synthesizing large collections of diverse multimeric compounds and iterative processes for assessing key molecular constraints that confer multibinding properties on multimeric compounds are disclosed. A librar...
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JP2002517461A |
Disclosed are multibinding compounds which are bradykinin antagonists. The multibinding compounds of this invention contain from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a b...
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JP2002517422A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002517460A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002517421A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002517462A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002517457A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002517464A |
Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of eac...
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JP2002517437A |
Novel multi-binding compounds (agents) are disclosed which bind cell membrane transporters including ion channels, molecular transporters and ion pumps. The compounds of this invention comprise from 2 to 10 ligands each of which can bind...
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JP2002517463A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002517465A |
This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligan...
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JP2002517420A |
Disclosed are novel multi-binding compounds (agents) which bind cellular receptors. The compounds of this invention comprise a plurality of ligands each of which can bind to such cellular receptors thereby modulating the biological proce...
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JP2002128797A |
To provide a method for producing an antiviral peptide from a food material whose safety is confirmed.This peptide is obtained by treating butter milk with cysteine protease. The peptide thus obtained has a molecular weight of 1-100 kDa,...
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JP2002512809A |
The invention provides gcp polypeptides and polynucleotides encoding gcp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gcp polypeptides to screen for antibacte...
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