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JP2002101882A |
To provide a DNA encoding the phospholipase A2 of Asterina pectinifera, to provide a vector into which the DNA is inserted, to provide a transformant holding the vector, and to provide a method for producing the phospholipase A2 by the u...
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JP2002509736A |
Signaling pathways dependent on members of the corticotropin releasing factor (CRF) gene family exert pleiotropic effects within both the brain and peripheral tissues. Two biochemically and pharmacologically distinct corticotropin releas...
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JP2002510051A |
The invention provides methods for identifying agents that are ligands for nuclear receptors. The methods include conducting multiplexed assays utilizing positive hybrid systems, reverse hybrid systems, direct interaction assays and othe...
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JP2002085062A |
To develop a conjugate comprising chemically-defined, non-polymeric valency platform molecule usable for treating diseases such as autoimmune disease systemic lupus erythematosus(SLE) or the like.The chemically-defined, non-polymeric val...
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JP2002080320A |
To provide a cosmetic which needs viscosity, has an imparted thickening action, improves hair combability, prevents the branching of hair, imparts gloss and moisture to skins, and smoothens the skins, or a cosmetic which does not need th...
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JP2002508130A |
(57) [Summary] Representing a monomer in a biological sequence using the entire byte is not the most efficient means of permanent storage. The present invention relates to the compression of biological sequence data for electronic storag...
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JP3262868B2 |
PURPOSE: To prepare new 8-hydroxy-2H-dibenz[b,f]azepin-2-one based dyes useful as acid/base indicators and acting as the chromogenic matrix of hydrolase. CONSTITUTION: A compd. of formula I (X is CH2CH2 or CH=CH; Y is H or a group cuttab...
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JP2002505845A |
Disclosed is a method of producing random polynucleotides by introducing two or more related polynucleotides into a suitable host cell such that a hybrid polynucleotide is generated by recombination and reductive reassortment. Also provi...
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JP3261383B2 |
DNA encoding a novel human beta 2 integrin alpha subunit polypeptide, designated alpha d, is disclosed along with methods and materials for production of the same by recombinant procedures. Fusion proteins are also disclosed which includ...
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JP2002047264A |
To provide an intermediate for synthesis of serine protease inhibitor and a method for producing the same.In order to produce a compound represented by general formula (I) [W1 is a protecting group for N-terminus; A2 represents structura...
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JP2002503813A |
The present invention provides methods and compositions for screening, diagnosis and prognosis of hepatoma, for monitoring the effectiveness of hepatoma treatment, and for drug development. Hepatoma-Diagnostic Features (HFs), detectable ...
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JP3250220B2 |
There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly...
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JP3233779B2 |
PURPOSE: To produce a peptide-containing composition having low allergic action, containing decreased amount of bitter taste and odor component and useful for the preparation of modified milk for baby by decomposing casein with a proteas...
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JP2001322974A |
To provide the subject compound as starting material in synthesizing a serine protease inhibitor, and to provide the corresponding new structural fragment in the above inhibitor.This compound itself shown by the formula or the correspond...
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JP2001517196A |
Disclosed are methods of therapy applicable to pathologies that involve loss of integrity of tissue and organ membranes that lead to abnormal permeation of proteinic and other agents and their elimination or penetration of other anatomic...
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JP2001514192A |
The invention relates to a method for isolating anionic organic substances from aqueous systems using polymer nanoparticles with cationic pH-sensitive surface groups. Extraction can be carried out directly from diluted solutions, biologi...
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JP2001514232A |
The present invention provides for a method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase activity which comprises administering to the subject an amount of a zinc sphingomyelina...
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JP3205558B2 |
There is provided the combination of acetylsalicylic acid and a compound of the general formula I A<1> - A<2> - NH - (CH2)n - B wherein A<1>, A<2>, n and B have meanings given in the description, for use in therapy.
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JP2001220398A |
To provide a valuable application technology for the albumen of an egg of silky fowl.This hydrolyzed albumen is an oligopeptide or a low molecular weight peptide having 50-1,000 molecular weight and is produced by hydrolyzing the albumen...
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JP2001509672A |
The invention concerns gene banks and combinatorial derivatives thereof, prepared using phagemid- or phage-display in combination with type IIS restriction enzymes and cosmid packaging; their use for the isolation of ligands, including e...
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JP2001508864A |
A method for detecting the condition of an organism through the measurement of peptides from a sample of said organism containing high- and low-molecular weight peptides, as an indication of the condition of said organism, whereinlow-mol...
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JP3180161B2 |
PURPOSE: To separate in high purity mixture containing erythrocyte membrane substance and blood type substance from a hemoglobin solution using a hemolysate as raw material. CONSTITUTION: In a method for separating a hemolysate into a mi...
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JP3173794B2 |
The present invention provides a protein or polypeptide substance having at least one amino group bonded to a polyethyleneglycolosy group represented by the following general formula; R1 -(OCH2 CH2) n - O - (wherein R1 represents an opti...
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JP2001095496A |
To obtain a whey protein hydrolysate having a good flavor, excellent in heat stability in its acid zone and also having a low buffering activity, and its method for production. This whey protein hydrolysate is provided by having physical...
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JP2001503376A |
The invention relates to cobalt compounds in which divalent or trivalent cobalt is complexed with water soluble tetradentate Schiff's bases. The tetradentate Schiff's bases preferably contain two nitrogen atoms and two oxygen atoms as co...
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JP3138513B2 |
PURPOSE: To provide the subject separation agent composed of a stationary phase consisting of a lysozyme bonded to a carrier, producible at a low cost and resistant to the denaturation by organic solvent. CONSTITUTION: The objective sepa...
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JP2001502183A |
The present invention relates generally to therapeutic and diagnostic agents. More particularly, the present invention provides therapeutic molecules capable of modulating signal transduction such as but not limited to cytokine-mediated ...
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JP2001502293A |
The instant invention is directed to a single, selectively N-alkylated compound and libraries of such compounds as set forth in Formula (I). Furthermore, the instant invention is directed to methods of effecting analgesia, a decrease in ...
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JP2001500379A |
(57) [Summary] Purified protein TPC2 and recombinant protein TPC2 and purified protein TPC3 and recombinant protein TPC3, as well as recombinant oligonucleotides or synthetic oligonucleotides corresponding to those proteins or fragments ...
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JP3119680B2 |
Balhimycin, a compound of the molecular formula C66 H73 Cl2 N9 O24 , is a novel Glycopeptide antibiotic.
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JP3108059B2 |
To produce a composition containing a physiologically active peptide having angiotensin I converting enzyme inhibiting action and excellent safety and useful as a dermatologic preparation, cosmetic, or the like, by treating polished adla...
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JP2000514651A |
Disclosed is a process of performing Sexual PCR which includes generating random polynucleotides by interrupting or blocking synthesis or amplification process to slow or halt synthesis or amplification of at least one polynucleotides, o...
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JP3103582B2 |
The surfactant suspensions are used for replacement therapy in respiratory tract disorders. The suspensions contain calcium and/or magnesium ions bound to the surfactant and unbound in the suspending agent and have a defined content of s...
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JP2000264900A |
To obtain a pathologically active peptide having an inhibitory activity against cell adhesion composed of amino acids of specific residue number, having a specific amino acid sequence, an antagonistic action on a cell adhesion factor for...
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JP2000511880A |
The present invention provides calixpyrrole, calixpyridinopyrrole, and calixpyridine macrocycles, having 4, 5, 6, 7, or 8 heterocyclic rings, as well as syntheses, derivatives, conjugates, multimers, and solid supports thereof. Such macr...
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JP2000511629A |
The present invention provides an assay apparatus for that includes a temperature adjusting means for simultaneously heating a plurality of samples, and a receiving means for receiving spectral emission from the samples while the samples...
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JP3073997B2 |
Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine o...
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JP2000508899A |
Disclosed is a nucleic acid molecule encoding a chimeric synthase polypeptide including a first isoprenoid synthase joined to a second domain from a second, different isoprenoid synthase, whereby the chimeric isoprenoid synthase is capab...
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JP3054194B2 |
An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. ...
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JP2000139475A |
To obtain a new polynucleotide which has high homology to a nucleic acid coding for FabH polypeptide containing a specific amino acid sequence, and can be used for screening antibacterial compounds, treating and/or diagnosing the infecti...
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JP2000503856A |
The present invention relates to methods and materials for the recombinant microbial production of fusion proteins and peptides derived from or based on Domain I (amino acids 17-45), Domain II (amino acids 65-99) and Domain III (amino ac...
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JP2000063399A |
To industrially efficiently obtain a physiologically active peptide useful for treating hypertension in a high yield by adding a protease and a raw material protein to a specific aqueous two-phase partition system and carrying out a pept...
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JP2000500974A |
This invention provides a method for determining whether a compound is capable of suppressing ras functions comprising: (a) contacting an effective amount of the compound with Ha-ras transformed cloned rat embryo fibroblast cells under c...
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JP3000033B2 |
PURPOSE:To obtain the subject peptide useful for preventing infectious diseases caused by a bovine small piroplasmosis protozoa, i.e., Theileria sergenti. CONSTITUTION:This peptide comprises the one consisting of a partial amino acid seq...
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JP2986915B2 |
An invention is described that permits the regulation of recombination in cells, organism or appropriate cell-free systems. The invention involves creating fusion proteins between recombinase proteins, or components of recombinase system...
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JPH11512479A |
Disclosed are methods of therapy applicable to pathologies that involve loss of integrity of tissue and organ membranes that lead to abnormal permeation of proteinic and other agents and their elimination or penetration of other anatomic...
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JPH11262392A |
To obtain new polynucleotides, for example. for treatment and diagnosis of infectious diseases caused by bacteria belonging to the genus Streptococcus, such as tympanitis, conjunctivities, pneumonia, and bacteremia. The polynucleotides h...
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JPH11262393A |
To provide a method for identifying an agonist and an antagonist, concerning tumor necrosis-related receptors TR1, TR3 and TR5, by contacting a candidate compound with each of TR1, TR3, and TR5, in the presence of ligand TL3. followed by...
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JP2945995B2 |
PURPOSE:To obtain the title mixture useful as a nutrition feeding agent, having improved bitterness, smell and taste and excellent flavor and palatability by subjecting animal protein to enzymolysis with endoprotease and exoprotease in a...
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JPH11225777A |
To obtain a novel polynucleotide having high identity to a nucleic acid encoding for a polypeptide containing a specific amino acid sequence and used for the screening of antibiotic activities, the treatment and prevention, etc., of Stap...
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