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WO/2024/015527A1 |
In alternative embodiments, provided are drugs and companion diagnostics, or therapeutic drug combinations and a companion diagnostic comprising a dried blood spot or a volumetric dried blood spot, or an at-home high-volume liquid blood,...
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WO/2023/062413A9 |
Gas storage ledger system 1, comprising a gas smart meter 10, capable to measure on- site 40 a quantity Q of gas to be stored in an underground reservoir too and to provide gas quantity data 12 corresponding to the quantity of gas measur...
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WO/2024/013330A1 |
The invention relates to a method of obtaining a variant of a T cell epitope peptide expressed in the tumour of cancer patient, wherein the variant is characterised by targeted amino acid substitutions conferring an improved capacity to ...
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WO/2024/014489A1 |
In the present invention, a cell image acquisition unit acquires a first image of a cell in which a first component is labeled and a second image of the cell in which a second component differing from the first component is labeled. A fe...
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WO/2024/015418A1 |
The inventions provide immunoassays for reducing the effects of inteference in the detection and quantification of analytes, including but not limited to cytokines, enzymes, antibodies, and others by acidifying samples and allowing for b...
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WO/2024/015522A1 |
Compositions and methods are provided for characterizing microbes and extracellular vesicles derived therefrom. The characterization of compositions of microbes and extracellular vesicles derived therefrom are also provided.
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WO/2024/013534A1 |
The invention relates to a method and a system (1) for analyzing one or more compounds in a hydrocarbon-containing sample. The method comprises steps of: a) injecting the sample and a first solvent into a chamber (3; 300) so that the one...
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WO/2024/014536A1 |
The present invention relates to a compound represented by a general formula (1) or a salt or a solvate thereof. [In the formula, R1, R2, and R3 are as defined in the description.]
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WO/2024/013487A1 |
Provided herein are methods and compositions for the on-device detection of protein synthesis using fluorescent proteins. The methods are applicable to monitoring on a microfluidic device.
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WO/2024/015310A2 |
The invention features a composition including (i) pro-parathyroid hormone (pro-PTH); and (ii) an antibody that specifically binds to pro-PTH.
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WO/2024/015927A2 |
Provided herein is technology relating to detecting analytes and particularly, but not exclusively, to methods, compositions, systems, and kits for detecting analytes using aptamer technologies.
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WO/2024/014426A1 |
The present invention addresses the problem of clarifying the true cause of interstitial pneumonia that is associated with myositis/dermatomyositis to thereby enable a more accurate diagnosis of the onset risk of interstitial pneumonia a...
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WO/2024/014764A1 |
The present invention relates to an electrode for an electrochemical sensor and an electrochemical sensor employing the electrode as a working electrode, wherein the electrode comprises: a working electrode layer; an enzyme reaction laye...
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WO/2024/013713A1 |
The present invention relates to the field of the point-of-care devices and, in particular, it relates to a new lateral flow device and a reading device of a chromatographic strip, to detect and/or quantify one or more thyroid function r...
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WO/2024/013301A1 |
An assay plate system (1100) for assaying a cell culture model such as an organoid is described. The assay plate system comprises an assay plate (200) comprising an upper surface (201) and comprising a grid array of wells comprising at l...
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WO/2024/015904A2 |
An indicator system comprising permanganate, an organic reducing agent, an acid, and an inorganic perchlorate salt is provided herein. Methods for using the indicator system to monitor the integrity of a biospecimen are also provided. Th...
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WO/2024/013521A1 |
The invention provided herein relates to methods for protein synthesis, purification and characterisation.
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WO/2024/015702A1 |
Disclosed herein is a method, comprising administering to a subject in need thereof an initial immunogenic composition comprising a plurality of tumor-specific neoantigens, each corresponding to a member of a first set of tumor-associate...
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WO/2024/014498A1 |
The purpose of the present invention is to provide a method for evaluating the occurrence of lymph node metastasis of endometrial cancer or the lymph node metastasis capability of endometrial cancer with high accuracy. Provided is a meth...
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WO/2024/011307A1 |
Compounds of Formula I: Formula I and pharmaceutically acceptable salts thereof are provided for as inhibitors of SGK-1 for example for the treatment of conditions such as Long QT syndrome, heart failure, arrhythmia, ischemic injury, isc...
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WO/2024/013229A1 |
Provided herein is a method of diagnosing or prognosing advanced liver fibrosis or liver cirrhosis in a patient. The method is accomplished by determining a score based on the circulating levels in serum of two markers.
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WO/2024/012494A1 |
The present invention belongs to the technical field of urine examination devices. Disclosed are a health monitoring apparatus and a health monitoring toilet. The key points of the technical solution involve the health monitoring apparat...
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WO/2024/013228A1 |
Provided herein is a method of diagnosing or prognosing advanced liver fibrosis or liver cirrhosis in a patient. The method is accomplished by determining a score based on the circulating levels in serum of three markers.
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WO/2024/013731A1 |
The present application provides a system for determining a dosage of a diuretic required by a subject suffering from or at risk of heart failure, which facilitates a "closed loop" of measuring urinary parameters and treating. The system...
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WO/2024/012487A1 |
Provided is a protein including a polypeptide having at least 95%sequence homology with an amino acid sequence selected from a group consisting of SEQ ID NOs: 1 to 5, where the amino acid at position 70 of SEQ ID NOs: 1-5 must be cystein...
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WO/2024/015577A1 |
Systems and methods for the treatment of infectious diseases and cancers is provided. Aspects of the invention include a method comprising collecting a small stool sample from a human patient using noninvasive means, isolating the gut ce...
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WO/2024/014470A1 |
To develop a new tumor preventative/therapeutic. Provided are: an agent for preventing and/or treating a tumor, the agent containing, inter alia, an IKZF1ΔE5 protein, which is a deletion variant of IKZF1 in which part or all of exon 5...
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WO/2024/013743A1 |
An in vitro culture model for inflammation is provided. The method comprises tissue cells and immune cells, wherein the tissue cells and immune cells are of different species and are in direct contact. Also provided is an in vitro method...
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WO/2024/015722A2 |
FRET-based fusion protein biosensors and methods for their use in measuring an NAD+/NADH ratio change in live cells are provided.
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WO/2024/014930A1 |
Provided are: a novel anti-ROR1 antibody; a bispecific antibody comprising the anti-ROR1 antibody; and uses thereof.
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WO/2024/012839A1 |
The invention relates to a method for quantifying a first solution, containing at least one nucleic acid, comprising: thinning (32) the first solution with a second solution containing at least one intercalating fluorescent dye; carrying...
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WO/2024/015349A1 |
A method for providing treated water comprises introducing water to be treated into a water treatment system, treating the water to be treated in the water treatment system to produce a treated water, measuring a quality parameter of the...
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WO/2024/013381A1 |
The invention relates to a method of detecting an interaction or proximity between a fusion protein and a target protein. The method may comprise a) providing a fusion protein and/or a recombinant nucleic acid molecule encoding said fusi...
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WO/2024/015378A1 |
The present disclosure relates generally to methods and systems for the characterization of antigen-binding molecules, e.g., B cell receptors, antibodies, and antigen-binding fragments thereof, using single-cell immune profiling methodol...
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WO/2024/014472A1 |
Provided is a vehicle interior member equipped with a personal authentication device capable of performing personal authentication of an occupant even when the outward physical features of the occupant have changed. A vehicle interior ...
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WO/2024/013293A1 |
A method for retrieving at least one alternating current (AC) signal (SAC) from at least one measurement signal (Smeas) of at least one detector (124) is proposed. The measurement signal (Smeas) comprises the AC signal (SAC) and at least...
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WO/2024/015856A1 |
The present disclosure relates generally to compositions, methods, and systems for the characterization of binding charactersitics of antigen binding molecules, e.g., antibodies, using single-cell immune profiling methodologies. The comp...
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WO/2024/014619A1 |
The present invention relates to a neutralizing antibody or an antigen-binding fragment thereof for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2) or variant viruses thereof. The neutralizing antibody of the present inventio...
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WO/2024/013234A1 |
The multisystem inflammatory syndrome accounts for a large proportion of COVID-19- related myocarditis in adults (MIS-A). The inventors compared the characteristics of fulminant COVID-19-related myocarditis (n=38) between patients fulfil...
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WO/2024/015486A1 |
Biomarkers, methods, devices, reagents, systems, and kits used to assess the quality of a sample collected from a subject are provided. Such biomarkers, methods, devices, reagents, systems, and kits may be useful in evaluating acceptabil...
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WO/2024/014336A1 |
This freshness maintaining system (1) comprises: a freshness detection unit (2) which detects ethylene gas and detects the freshness of a crop; and a maturation suppression unit (3) which emits light having a sterilizing function. A proc...
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WO/2024/015743A1 |
This disclosure provides for engineered T cell Receptors (TCRs), cells comprising the TCRs, and methods of making and using the TCRs. The current disclosure relates to TCRs that specifically recognize epitope(s) from tumor antigen VCY CT...
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WO/2024/013379A1 |
The invention is directed to a method for producing a roll (1) or sheet of membrane units (2) for a membrane product (3) such as a lateral flow test from a roll (6) or sheet of membrane material (7), by means of a primary production arra...
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WO/2024/012695A1 |
An electrolyte composition for use in an electrochemical sensor, said electrolyte composition comprising at least one hygroscopic compound comprising at least two moieties (HB) with hydrogen bonding capability and at least one hydrophili...
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WO/2024/015485A1 |
The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the evaluation of risk of dementia in a middle-aged individual within a specified timeframe, for example 5, 10, 15 and/or 20 years. In one aspe...
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WO/2024/013024A1 |
The present disclosure relates an electrochemical biosensor system for measuring concentrations of an analyte (thyroid-stimulating hormone, TSH) in a fluid, the system comprising an electrochemical sensor having a working electrode havin...
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WO/2024/012513A1 |
Provided are antibodies and antigen-binding fragments thereof, and in particular to such antibodies and antigen-binding fragments that have affinity and activity of stimulating T cell activation. Uses of such antibodies and antigen-bindi...
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WO/2024/015733A1 |
The present disclosure relates generally to the field of immunology, and particularly relates to improved methods and systems useful for identification and characterization of antigen-binding molecules (ABMs) obtained from biological sam...
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WO/2024/013120A2 |
The present invention relates to Lichen planus (LP), and more specifically to no erosive form of LP (NELP). The invention provides an immune signature for LP, which is not found in other cutaneomucosal chronic inflammatory diseases. The ...
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WO/2024/015973A1 |
Methods and systems for determining a tumor DNA fraction for a sample from a subject are described. In some instances, the methods comprise receiving sequence read data for a plurality of sequence reads derived from the sample from the s...
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