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WO/2024/025989A1 |
The invention provides pharmaceutical compositions of anti-PD-1 antibodies or antigen-binding fragments thereof with less than or equal to about 3.0 % oxidation of Met105 in the CDRH3 heavy chain region, and rHuPH20 or variants or fragme...
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WO/2023/114915A9 |
The invention provides compositions and methods comprising biomarker genes for identifying subjects that will respond to human MAP kinase kinase (MEK) inhibitor therapies, compositions and methods comprising biomarker genes for identifyi...
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WO/2024/023313A1 |
The invention relates to genetically engineered mouse models for multiple myeloma (MM) and their uses thereof for the development of multiple myeloma models as well as for the screening of compounds suitable for the treatment of multiple...
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WO/2024/026467A1 |
Described herein are 1,2-dioxetanes that are useful as chemiluminescent probes, diagnostic agents, and imaging agents. Also described herein are compositions containing such compounds and methods of using the same.
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WO/2024/023139A1 |
In the present invention, inventors used highly sensitive, immunoassay platform, to analyze combined cytokine profiles in serum of patients with Pulmonary Arterial Hypertension (PAH) ((EFFORT cohort). Thereafter, this approach allows to ...
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WO/2024/026465A1 |
Described in several example embodiments herein are engineered programmable pattern recognition compositions and uses thereof. In certain example embodiments, the engineered protein contains an NTPase of a Signal Transduction ATPases wit...
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WO/2024/025720A1 |
An apparatus for locating and venting pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light ...
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WO/2024/025712A1 |
A method for performing a screening includes illuminating a sample with light from a screen of a system at a first wavelength while the system is at a predetermined position with respect to the sample. The method also includes capturing ...
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WO/2024/025716A1 |
An operational unit for locating and neutralizing pathogen cells in blood includes a cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates the holding chambers...
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WO/2024/026114A1 |
Methods, systems, and apparatus, including computer programs encoded on computer storage media, for proteome mapping. One of the methods includes: identifying one or more target peptide sequences for a sample; estimating an elution order...
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WO/2024/025268A1 |
The present invention relates to a gas collection device, and aims to provide a gas collection device that is capable of providing gas concentration optimized for an analysis device by controlling the space where gas is diffused when col...
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WO/2024/023849A1 |
The present invention relates to IoT based breath analyser device. The device initially collects human breath through mouthpiece (100) into a silicon bag (104) enclosed with a hand compressor (103). The sampled breath is pushed into the ...
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WO/2024/025322A1 |
The present invention relates to an autonomous mobile system for detecting hazardous substances in the air, and comprises: a collection unit including a traveling part that autonomously travels under the control of an MCU, and a collecti...
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WO/2024/026384A1 |
The present disclosure is directed to antibodies binding to human endotrophin and methods for use of such antibodies to detect endotrophin in human samples.
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WO/2024/026109A1 |
The disclosed technology relates generally to compositions, methods, and system for utilizing paraxanthine alone and in combination for use in enhancing immune function and/or inhibiting inflammation through administration of a paraxanth...
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WO/2024/025963A1 |
Systems, methods, and compositions that incorporate, utilize, or are generated by an Al-based UniBind™ framework are described. The Al-based UniBind™ framework includes three major components: protein representation as a graph at the...
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WO/2024/023522A1 |
The present disclosure is based in part on studies that identify upregulation of markers in response to stimulation by an antigen (also referred to as activation induced markers) to detect antigen-specific immune cells, and uses thereof....
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WO/2024/021059A1 |
Provided is a non-human mammalian model expressing IL-8 and use thereof. Specifically, provided is a non-human mammalian model expressing IL-8. The non-human mammalian model expressing IL-8 can be better used to prepare a tumor-bearing n...
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WO/2024/025973A2 |
The disclosure provides devices, methods and systems for continuous dielectrophoresis cell sorting to isolate different populations of cells, and applications thereof.
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WO/2024/025939A1 |
A system for collecting and separating floating debris and water from a body of water on a waterborne vessel includes at least one collection chamber, water discharge pump and sensor. The at least one sensor is communicably coupled to th...
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WO/2024/026318A2 |
This disclosure relates to antibodies and derivatives that bind the full-length isoform of aspartate beta-hydroxylase (ASPH) and uses thereof. The antibodies and derivatives are useful in compositions and methods for detecting and/or tre...
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WO/2024/022595A1 |
The invention relates to a soil moisture apparatus for plants, having a housing for accommodating the plants and having a moisture measuring device containing a first capacitor electrode and a second capacitor electrode and an evaluation...
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WO/2024/023138A2 |
The present invention relates to the field of optical imaging. More particularly, it relates to fluorescent probes targeting carbonic anhydrase nine (CA-IX) comprising near-infrared (NIR) dyes of the cyanine. The invention also relates t...
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WO/2024/026315A2 |
The present disclosure provides photocleavable linkers capable of embedding proteins, of biological samples, within swellable materials, methods for extracting at least one protein from a biological sample, and methods for protein identi...
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WO/2024/024147A1 |
Disclosed are: a method for identifying, by using refractive index distribution data of an observation object containing liver cells, bile canaliculus regions included in the observation object; and a method for evaluating the bile canal...
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WO/2024/024993A1 |
The present invention relates to an apparatus for correcting temperature-specific performance deviation of a photosensor, comprising a sensing unit, which includes a plurality of photosensors, and a control unit, which: detects, by means...
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WO/2024/021040A1 |
Provided is a cell identification method for identifying a target cell in combination with results of fluorescence intensity analysis, fluorescence image analysis and white-light image analysis.
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WO/2024/023283A1 |
The present study of the regulatory T phenotype of Sézary cells led to the discovery of the expression of LRRC33 by Sézary cells. LRRC33 therefore appears as a diagnostic marker, for monitoring Sézary syndrome, and as a therapeutic ta...
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WO/2024/026400A2 |
This disclosure relates to therapeutic combinations of TITR effectors such as CCR8 targeting agents, radiation therapy and checkpoint inhibitors and methods of using the same for the treatment of cancer. The disclosure also relates to me...
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WO/2024/023546A1 |
A self-deployable apparatus for facilitating collecting data from multiple depths of water bodies. Further, the self deployable apparatus comprises a main body, substances, a sensor, a storage device, and a power source. Further, the sub...
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WO/2024/020629A1 |
Provided is a soil carbon sensor (10) comprising a probe body (12) configured for operative placement into soil (8), as well as a first detector (14) supported by the probe body (12) and configured to transmit a frequency-modulated signa...
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WO/2024/025722A1 |
A method and apparatus for locating and venting pathogen cells in blood. A cassette has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and pas...
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WO/2024/026268A1 |
A gas sensor array system includes a gas sensing chamber, a sensor array provided within the gas sensing chamber and including a plurality of gas sensing components each gas comprising a gas adsorbing material (such as an MOF material), ...
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WO/2024/020122A1 |
The methods, compositions and kits described herein provide signal amplification approaches for the detection of target biomolecules that significantly increase the sensitivity of detection using target-binding ligand molecules. The meth...
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WO/2024/017361A1 |
Provided are an isolated monoclonal antibody or an antigen-binding fragment thereof against Trop2, and use of the antibody or fragment in tumor treatment and diagnosis.
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WO/2024/017984A1 |
The present invention relates to a method for diagnosing Polycystic Ovarian Syndrome (PCOS) in a subject, said method comprising the steps of a) determining the amount or concentration of total LTA4H in sample from the subject, b) determ...
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WO/2024/018046A1 |
The present study of the regulatory T phenotype of Sézary cells led to the discovery of the expression of GARP (LRRC32) by Sézary cells. GARP has also been shown to be overexpressed in samples from patients with acute lymphoblastic leu...
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WO/2024/017667A1 |
A system (12) for estimating total dissolved solids (TDS) concentration in boiler water is described which comprises: a sensor (14) having a transmitter configured to transmit an RF or microwave signal into the boiler water and a receive...
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WO/2024/019245A1 |
The present invention relates to an intraocular lens using a Moiré interference hydrogel. The Moiré intraocular lens according to the present invention makes it possible to easily detect the presence of and quantitatively detect a targ...
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WO/2024/016048A1 |
A kit comprising a protein containing substance for dispersion in a liquid, a sample collection device for collecting a sample from the liquid, the sample containing matter derived from faecal material, and a test device configured to de...
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WO/2024/017983A1 |
The present invention relates to a method for assessing whether a subject has Polycystic Ovarian Syndrome (PCOS) or is at risk of developing PCOS, to a method of selecting a patient for therapy of PCOS, to a method for monitoring PCOS pr...
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WO/2024/017632A1 |
An assay device (1) for electrochemical sensing of a sample fluid comprises, at least one substrate (2), at least one electrode (3), and at least one channel (5). The channel (5) extends at least partially in the substrate (2) and is con...
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WO/2024/018470A1 |
A method of diagnosing an infectious disease, including determining the severity of the disease, in a subject comprising measuring an expression level of at least one protein selected from the group consisting of TSG-14, AGER, ANG-2 and ...
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WO/2024/020130A1 |
In some embodiments, a spectral tensor technique includes the steps of generating a power spectrogram and a phase spectrogram for the breath triplet; removing high frequency bins from each spectrogram; generating a spectral image by sizi...
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WO/2024/017982A1 |
The present invention relates to a method for assessing whether a subject has Polycystic Ovarian Syndrome (PCOS) or is at risk of developing PCOS, to a method of selecting a patient for therapy of PCOS, to a method for monitoring PCOS pr...
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WO/2024/020527A1 |
The present invention provides methods for using waste effluent biofluids in cell culture assays as all or part of the cell culture microenvironment. Methods of the invention contemplate that biofluids typically regarded as waste may be ...
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WO/2024/020596A1 |
Fusion proteins, comprising at least one single chain antibody fragment (scFV), and a cancer antigen or marker, or a fragment thereof are provided. The scFV is capable of selectively binding to a cytokine released by chimeric antigen rec...
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WO/2024/019963A1 |
The systems and methods of the invention provide several improvements directed at fertility treatment. These improvements include an expert/AI system configured to guide a caregiver, e.g., a physician, through the process of providing fe...
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WO/2024/018227A1 |
This specification relates to systems (100), methods and apparatus for intelligently controlling the drum rotation of a concrete mixer (104). According to a first aspect of this specification, there is described a method for controlling ...
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WO/2024/019504A1 |
The present invention relates to a gas collection device and aims to provide a gas collection device which can capture gas at an appropriate concentration level for batteries with cases made of various standards of rigid materials, parti...
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