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Title:
GENE EXPRESSION LEVEL STANDARDIZATION METHOD, PROGRAM, AND SYSTEM
Document Type and Number:
WIPO Patent Application WO/2006/051670
Kind Code:
A1
Abstract:
A method for acquiring a high-reliability high-accuracy index for standardizing a gene expression level measured separately so as to compare and examine the gene expression level is presented to enhance the reliability and accuracy of gene expression level standardization. A method for standardizing a gene expression level measured for gene expression analysis by using gene expression levels measured for index acquisition wherein the correlation among the gene expression levels measured for index acquisition is determined using a correction function, and the acquired correlation is used as an index for standardizing a gene expression level measured for gene expression analysis. The correlation function can be determined by sampling cells (31) and two or more experiment conditions, acquiring gene expression levels gn for each experiment condition from the cells (31), using the correlation among the gene expression levels for each experiment condition (numeral 34 to 38) as function values, and selecting a combination of function values each approximate to a certain value.

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Inventors:
OHTO YASUNORI
ABE TOMOTERU
Application Number:
PCT/JP2005/019033
Publication Date:
May 18, 2006
Filing Date:
October 17, 2005
Export Citation:
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Assignee:
SONY CORP (JP)
OHTO YASUNORI
ABE TOMOTERU
International Classes:
G01N33/53; G16B25/10; C12N15/09; C12Q1/68; G01N37/00; G06F17/30; G06F19/00; G16B40/10
Foreign References:
JP2003194812A2003-07-09
JP2003028862A2003-01-29
JP2005080588A2005-03-31
JP2004294080A2004-10-21
Other References:
BENES V. ET AL: "Standardization of protocols in cDNA microarray analysis", TRENDS BIOCHEM SCI, vol. 28, no. 5, 2003, pages 244 - 249, XP004425563
See also references of EP 1821101A4
Attorney, Agent or Firm:
Nakamura, Tomoyuki c/o Miyoshi International Patent Office (Toranomon Kotohira Tower 2-, Toranomon 1-chome Minato-ku Tokyo 01, JP)
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