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Matches 301 - 350 out of 50,923

Document Document Title
WO/2020/146902A3
The present application discloses an antibody, or fragment thereof, for the diagnosis, treatment or prevention of cancers wherein the antibody specifically binds to the PSMGFR peptide (SEQ ID NO:2) or a fragment thereof of the peptide.  
WO/2020/171055A1
This invention provides an alcoholate of (S)-N-[(S)-1-hydroxypropan-2-yl]-4-methyl-1-[2-methyl-4-(3-m ethyl-1H-pyrazol-1-yl)benzoyl]-2,3,4,5-tetrahydro-1H-benzo[b ]azepine-4-carboxamide represented by formula (I), or a crystal thereof, w...  
WO/2020/171206A1
This invention provides technology for identifying the marker protein of myofibroblasts and preventing or treating fibrotic disease. This invention relates to a preventive or therapeutic drug for fibrotic disease, which contains a GPR176...  
WO/2020/168148A1
Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein Q is C2-6 alkenyl or C2-6 alkynyl, each substituted with zero to 2 R1; and the other variables are as defined herein. These comp...  
WO/2020/168149A1
Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is: (i) halo, cyano, hydroxyl, NRxRx, C(O)OH, C(O)NH2, C1-6 alkyl substituted with zero to 6 R1a, ...  
WO/2020/168143A1
Disclosed are compounds of Formula (I) or a stereoisomer, a tautomer, or a salt or solvate thereof, wherein all the variables are as defined herein. These compounds modulate the activity of farnesoid X receptor (FXR), for example, as ago...  
WO/2019/218995A9
Provided is a method for the biomimetic culture of urothelial cells from mammalian bladders, including murine, porcine, bovine and human sources to isolate and expand urothelial cells for use in various applications, such as intravesical...  
WO/2020/166710A1
The present invention provides: a compound represented by formula (I), or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing the same.  
WO/2020/166557A1
The purpose of the present invention is to provide: a method for treating pregnancy-induced hypertension nephrosis, the method being characterized by administering antithrombin; and a novel composition for treating pregnancy-induced hype...  
WO/2020/165906A1
Compositions comprising electrospun fibers and active (e.g. pharmaceutical) agents encapsulated thereto are provided. Further, articles and methods of use of the fibers, including, but not limited to coating of medical tubing, are provided.  
WO/2020/167748A1
Methods of treatment include administering effective amounts of a nitrogen oxide (NO) donor (such as nicorandil) and a hydrogen sulfide (H2S) releasing agent (such as zofenopril) to a subject in need thereof. In various embodiments, the ...  
WO/2020/165925A1
The present invention provides cnidimoside A for use in the treatment of urinary conditions such as overactive bladder and related syndromes. The invention also relates to methods of treatment of overactive bladder using cnidimoside A. T...  
WO/2020/160707A1
Provided are alkylboronic acids as arginase inhibitors represented by formula (I), or a pharmaceutically acceptable salt, stereoisomer, tautomer, or prodrug thereof and a pharmaceutical composition comprising said compounds.  
WO/2020/160620A1
As animals, including humans, age, epigenetic changes to the DNA lead to methylation of the cytosines in the CpG islands, but also methylation of other nucleotides. Epigenetic changes are associated with the development of ageing-related...  
WO/2020/162612A1
The present invention provides a compound represented by formula (I'), which has an inhibitory effect on an enzyme that produces 20-HETE, or a pharmaceutically acceptable salt of the compound. (In formula (I'), ring D represents one of t...  
WO/2020/157362A1
The present invention relates to inositol phosphates, analogs, derivatives and pharmaceutically acceptable salts thereof, for use in increasing tissular perfusion and/or oxygenation in a subject in need thereof, in particular peripheral ...  
WO/2020/160151A1
A compound having one of formula (1), formula (2), formula (3) and formula (4) or a pharmacologically acceptable salt thereof.  
WO/2020/151633A1
Provided are pharmaceutical compositions which comprise a mixture of a lipophilic active pharmaceutical ingredient, at least one long chain fatty acid or at least one fatty acid glyceride, a surfactant, and optionally an antioxidant. Als...  
WO/2020/152869A1
Disclosed is an antisense nucleic acid that suppresses the expression of an NEK6 gene.  
WO/2020/151686A1
Provided in the present invention are an N-heteroaryl sulfonamide derivative, the preparation and use thereof. The N-heteroaryl sulfonamide derivative is an N-heteroaryl sulfonamide compound shown in general formula (I) or general formul...  
WO/2020/154581A1
The present disclosure relates to co-crystals of Fedovapagon, processes for preparation thereof as well as a pharmaceutical composition including the same.  
WO/2020/153503A1
Through the present invention, it was discovered that in cancer cells having high snhg12 expression, a reagent, which inhibits the expression of snhg12, significantly inhibited the engraftment or proliferation of the cancer cells. As a r...  
WO/2020/100089A3
The present disclosure provides compositions and methods to treat diseases and conditions related to smooth muscle dysfunction, or to ameliorate symptoms thereof comprising gene therapy, wherein one or more polynucleotides encoding one o...  
WO/2020/149645A1
The present invention provides a novel use of Sida rhombifolia. The present invention provides the benefit of effectively treating, ameliorating, inhibiting and/or preventing benign prostatic hyperplasia.  
WO/2020/149694A2
The present invention relates to a pharmaceutical composition for preventing or treating prostatic hyperplasia, comprising mixed extracts of Curcumae Radix and Syzygii Flos as an effective component. The mixed extracts were found to inhi...  
WO/2020/149393A1
The present invention addresses the problem of providing a method for selecting a fecal odor-improving substance and a method for producing a fecal odor-improving composition, and of providing a renal function-improving agent and a food/...  
WO/2020/148224A1
The invention relates to a composition for use in the treatment and/or prevention of lower urinary tract symptoms (LUTS). The invention is characterized in that it comprises a pollen extract containing an aqueous pollen extract obtained ...  
WO/2020/150170A1
New deuterated analogs of elagolix are provided. The novel deuterated elagolix analogs differ from the only previously disclosed deuterated elagolix analogs in structure based on the exclusion of deuterium at certain sites in the compoun...  
WO/2020/148760A1
The invention generally concerns a novel class of CB 1 receptor binding molecules and uses thereof.  
WO/2020/145416A1
The present invention pertains to a pharmaceutical composition for preventing or treating glomerular diseases, the composition containing ginsenoside Rg3 or a pharmaceutically acceptable salt thereof as an active ingredient. It was found...  
WO/2020/145250A1
[Problem] To provide a compound having a 15-PGDH inhibitory effect. [Solution] A compound represented by general formula (1) or a pharmacologically acceptable salt thereof.  
WO/2020/146615A1
Some embodiments of the invention provide compounds having the general formula (I) wherein R1, R2, R3a and R3b are as described herein, pharmaceutical compositions including the compounds, and the compounds for use in methods of treating...  
WO/2020/141226A1
A pharmaceutical composition and a method of administering the pharmaceutical composition to a patient suffering from edema, heart failure, kidney or liver disease or having symptoms thereofaredisclosed. The pharmaceutical composition in...  
WO/2020/142687A1
A method of treating chronic kidney disease including administering to a subject in need thereof a combination of a vitamin K and a phosphate binder.  
WO/2020/141552A1
The present invention herein discloses potent synergistic compositions of vasoactive mediators enhancers for improving vascular endothelial function. Particularly, the invention relates to synergistic nutritional composition comprising e...  
WO/2020/141224A1
A pharmaceutical composition and a method of administering the pharmaceutical composition to a patient suffering from edema, heart failure, kidney or liver disease or having symptoms thereof are disclosed. The pharmaceutical composition ...  
WO/2020/135474A1
A traditional Chinese medicine composition for treating chronic prostatitis and chronic nephritis, comprising the following raw material medicines in parts by weight: 5-20 parts of eucommia, 2-10 parts of radix astragali, 2-10 parts of d...  
WO/2020/138481A1
The present invention provides a crystal of 1-{2-[(3S,4R)-1-[(3R,4R)-1-cyclopentyl-3-fluoro-4-(4-methoxy phenyl)pyrrolidin-3-carbonyl]-4-(methoxymethyl)pyrrolidin-3- yl]-5-(trifluoromethyl)phenyl}piperidine-4-carboxylic acid, having a ce...  
WO/2020/138499A1
The purpose of the present invention is to provide a novel compound that has an excellent β-lactamase inhibitory activity. The present invention provides: a compound that has an excellent β-lactamase inhibitory activity and is represen...  
WO/2020/134921A1
Provided by the present invention are an amino quinazolinone and amino isoquinolone derivatives. It is verified by numerous experiments that the compounds provided by the present invention have good inhibiting effects on PI3Kα and PI3K...  
WO/2020/135058A1
Provided is a new crystal form of roxadustat and a preparation method thereof. The crystal form ARZ-A provided by the present invention has better stability and better solubility than the original crystal form. The preparation process of...  
WO/2020/125091A1
The present invention relates to the technical field of medicine, and specifically relates to a sterol composition in pumpkin seed oil, an application thereof, and a drug for treating benign prostatic hyperplasia. Disclosed is a sterol c...  
WO/2020/131807A1
The disclosure provides at least one entity chosen from compounds of formula (I), solid state forms of the same, compositions comprising the same, and methods of using the same, including use in treating focal segmental glomerulosclerosi...  
WO/2020/132594A1
An amorphous form of a compound having structure (I), or a pharmaceutically acceptable salt thereof, is provided. Such compounds may be used for the treatment of kidney diseases or disorders.  
WO/2020/131680A1
Described herein are methods for treating PKD in a subject suffering from PKD, the method comprising administering a therapeutically effective amount of at least one compound of the general formula (I), (I) or a pharmaceutically acceptab...  
WO/2020/125627A1
The present invention provides a compound. The compound is a compound as represented by formula (A) or a tautomer, a stereisomer, a hydrate, a solvate, a salt or a prodrug of the compound as represented by formula (A). R is R1 and R2 tha...  
WO/2020/132411A1
Methods and compositions for preventing or treating incontinence, overactive bladder, or menstrual cramping in a subject are described. A method can include providing a composition. The composition can include a modification agent. The m...  
WO/2020/122670A1
The present invention relates to a pharmaceutical composition, comprising tolvaptan, for preparation of a solid dispersion, and a preparation method therefor. Specifically, the present invention relates to a pharmaceutical composition fo...  
WO/2020/119192A1
A method for the dual-target construction of PROTAC and a specific construction method and use of dual-target PROTAC constructed using the method. The concept of dual-target design of PROTAC is proposed for the first time. That is, speci...  
WO/2020/120474A1
The present invention provides certain tetrapyrrolic compounds having a structure of Formula (1), (2), or (3) wherein B is (I), (II) (III) or (IV), O-R1 is a substituent in the meta or para position of the phenyl ring, R1 is a glyco-subs...  

Matches 301 - 350 out of 50,923