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JPS57136529A |
There is described an immunoglobulin conjugate comprising an immunoglobulin or immunoglobulin fragment modified by one or more groups of the following formula which are covalently linked to it: The conjugates are useful in the treatment ...
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JPS5735883B2 |
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JPS5734825B2 |
Process for the anilidization of carboxylic acid esters of the general formula R1COOR2, wherein R1 is a cycloaliphatic or substituted cycloaliphatic radical with 3-8 C-atoms, preferably 5-6 C-atoms, an aromatic or substituted aromatic ra...
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JPS5730091B2 |
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JPS5727884B2 |
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JPS5727883B2 |
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JPS5793982A |
beta -Lactam antibiotics of the formula in which A is a hydrogen atom, an optionally substituted alkyl, alkenyl, alkinyl or cycloalkyl group, a substituted or unsubstituted phenyl ring, a polycyclic aromatic ring or an optionally substit...
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JPS5764620A |
PURPOSE: To obtain an acid ester, etc. having one more carbon atoms safely without forming side chains, by reacting a trialkylsilyldiazomethane with a carboxylic acid chloride, and reacting the resultant intermediate with an amino or phe...
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JPS5716092B2 |
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JPS5715734B2 |
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JPS5710865B2 |
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JPS574610B2 |
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JPS5654304B1 |
1395347 Nitration of anthraquinone SANDOZ Ltd 5 June 1972 [10 June 1971 5 Oct 1971 20 Oct 1971] 26122/72 Heading C2C The nitration of anthraquinone using concentrated nitric acid is characterized in that, after commencement of and during...
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JPS56166162A |
A novel process for the preparation of acyl cyanides of the general formula R-CO-CN (I) wherein R represents an optionally substituted alkyl radical with 1 to 8 carbon atoms, an optionally substituted cycloalkyl radical with 3 to 12 carb...
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JPS56128744A |
The present invention describes the transhalogenation of amido compounds to obtain the corresponding N-haloamide through the use of an N-haloimide.
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JPS5635177B2 |
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JPS561290B1 |
1385368 Nitration process SANDOZ Ltd 27 April 1972 [30 April 1971] 19620/72 Heading C2C A nitration process using concentrated HNO 3 is characterized by adding dilute HNO 3 to reduce the rate of reaction, the amounts of concentrated and ...
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JPS55162746A |
PURPOSE: To prepare an amine derivative easily, in high yield, by reducing an amide compound with a specific combined reagent as a reducing agent. CONSTITUTION: An amine derivative (e.g. N-benzyl-1,2,3,4,5,6-hexahydroazepin) is prepared ...
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JPS55141418A |
PURPOSE: In the production of title compounds by the N-methylation of amines, silicon oxide or aluminum oxide is used as a catalyst to effect the reaction under neutral conditions to produce even polyfunctional and complicated compounds ...
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JPS5540569B2 |
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JPS55122727A |
PURPOSE: To effect the acylation of an alcohol or an amine extremely easily and safely in short time, by using a mixture of a low-priced cyanuric chloride relatively stable in air and an organic carboxylic acid salt. CONSTITUTION: An alc...
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JPS5533706B2 |
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JPS5516573B2 |
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JPS5516412B2 |
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JPS5553253A |
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JPS559013A |
PURPOSE: To obtain a coupling component directly usable for dye preparation, by alkylating an aromatic amine with an aromatic sulfonate in a hydrophilic alcohol as a solvent. CONSTITUTION: An aromatic amine of formula I: (A1 is benzene, ...
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JPS559045A |
PURPOSE: To prepare a mixture which can be used as a raw material of the succeeding coupling process in the manufacture of dyes without separation or purification, by reacting an aromatic amine with a specific amount of an aromatic sulfo...
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JPS554316A |
PURPOSE: To obtain a carbamate useful as a raw material for isocyanates, with a high selectivity, by reacting a carbonate with a primary or secondary amine in the presence of a catalytic amount of an organotin compound. CONSTITUTION: A c...
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JPS5452008A |
Process for preparing urea derivatives of the general formula in which R1, R2 and R3 denote identical or different lower alkyl groups which can optionally be substituted by other radicals such as ether or aryl groups, a heterocyclic radi...
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JPS5448712A |
: A process for the N-acetylisation of amino acids by reaction with ketenes in aqueous solutions. The process of the invention comprises dissolving the amino acid in an approximately equimolar quantity of aqueous alkali liquor to provide...
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JPS5441802A |
A process for the preparation of a nitrile of the formula R-(CN)n' wherein R represents an optionally substituted alkyl, cycloalkyl or aryl radical or an optionally substituted 5- or 6-membered heterocyclic radical which may additionally...
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JPS5419903A |
PURPOSE: To prepare an amino compound easily in high yield, reducing an oxime with a reaction product of sodium borohydride with an organic carboxylic acid.
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JPS53124237A |
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JPS5324935B2 |
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JPS5324041B2 |
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JPS5363331A |
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JPS5310563B2 |
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JPS5340724A |
PURPOSE: N-Alkylaniline derivatives are prepared in good yields by reacting aniline derivatives eith an alkylating agent in the presence of an acid bonding agent by use of aliphatic or alicyclic ketones as reaction media.
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JPS5248970B2 |
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JPS5245695B2 |
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JPS52128302A |
PURPOSE: To prepare amide compounds useful as intermediates for the medicines and pesticides, etc., while suppressing the formation of by-products, in high yields by the rearrangement of aldoxime compounds in the presence of a catalyst c...
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JPS5220961B2 |
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JPS5215561B2 |
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JPS5239601A |
PURPOSE: Nitration or oxidation products are obtained in high yield by nitrating or oxidizing aromatic hydrocarbons etc. with liquid N2 O4 and the treatment of the waste acid and the waste water is facilitated thereby.
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JPS5210201A |
This invention relates to a new method for the preparation of amines containing alkylene groups by using cyclic alkylene sulphuric esters, and novel intermediates for use in the method. The new method is useful for preparation of i.a. ph...
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JPS523001A |
PURPOSE: Aminoester is prepared in high yield by neutralizing its acid salt reaction solution with ammonia and by neutralizing the residual ammonium salt in the filtrate with an alkali metal alcoholate.
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JPS523B2 |
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JPS51138601A |
A method for preparing N(1)-alkylated-5-phenyl-7-substituted deoxy-1,4-benzodiazepines utilizing a polyphosphoric acid alkyl ester of the formula: wherein R3 is an alkyl radical with up to 4 carbon atoms as the alkylating agent, is descr...
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JPS5140042B2 |
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JPS5140043B2 |
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