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JP4505335B2 |
In the following, citalopram diol means 4-(4-dimethylamino)-1-(4-fluorophenyl)-1-hydroxybutyl)-3-(hy
droxymethyl)-benzonitrile, as free base and/or acid addition salt. The invention relates to a process for the preparation of racemic cit...
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JP4509377B2 |
A process for producing a compound of the formula (II): wherein R<1>, R<2>, R<3> and R<4> are each independently e.g. hydrogen, alkyl or alkoxy, R<5> is alkyl or alkoxyalkyl, A is 0 or S, Ar is aryl, * represents the position of an asymm...
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JP4503596B2 |
[PROBLEMS] To provide a process for the synthesis of cyclopentenenitrile derivatives through conjugate addition of a nitrile derivative to an ±,²-unsaturated ketone whereby cyclopentenenitrile derivatives, particularly those capable of...
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JP4503715B2 |
The separation of enantiomeric pairs of compounds by capillary electrophoresis using highly sulfated alpha -, beta -, and gamma -Cyclodextrins as chiral selectors is described herein. These charged cyclodextrins have a higher degree of s...
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JP2010522696A |
The invention relates to the use of compounds as new chiral selectors for separating the optical or enantiomeric isomers of a compound, wherein the chiral selector comprises at least one compound of formula (I): and at least one metal io...
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JP4491135B2 |
A process for preparing d-threo methyl ±- piperid-2-ylarylacetates of formula III: wherein R 1 is aryl having 6 to 28 carbon atoms, comprising the steps of: reacting a pyridine having formula I: wherein R 1 is aryl having 6 to 28 carbon...
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JP4493834B2 |
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JP4485797B2 |
Process for modifying the relative ratios of the components of a liquid starting mixture of specific diastereoisomers, containing at least two asymmetric carbon atoms comprising contacting said liquid mixture with a Lewis acid compound c...
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JP4488127B2 |
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JP4485742B2 |
A template (a molecule preferably of molecular size >500 Da, or a larger entity such as a cell, virus or tissue sample) is dissolved or suspended in a fluid. The fluid is frozen, and the template is removed (e.g. by dissolution or electr...
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JP4488891B2 |
This invention discloses and claims a compound of general formula (I) in which R1 represents either a hydrogen atom, or an optionally substituted alkyl group, or a cycloalkylalkyl group, or an optionally substituted phenylalkyl group, or...
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JP2010132907A |
To provide a series of novel charged cyclodextrins used for dividing (analyzing) a wide variety of chiral compounds by capillary electrophoresis. The charged cyclodextrins is selected from the group consisting of (a) α-cyclodextrin, (b)...
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JP2010132646A |
To provide an optically active N-alkoxycarbonyl-tert-leucine having high optical purity. The method for producing the optically active N-alkoxycarbonyl-tert-leucine comprises (1) a step of precipitating a racemic mixture of the N-alkoxyc...
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JP4483165B2 |
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JP4481659B2 |
Method of increasing the purity of low optical purity 1-benzyl-3-aminopyrrolidine (I) comprises converting (I) into a 1:1 mole ratio salt with an optically inactive acid and separating the salt in crystalline form. Method of increasing t...
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JP2010520188A |
A process for preparing a compound of formula (III) comprising condensing an oxiranyl compound of formula (I) with an amine of formula (II) or a salt thereof wherein: R1 is a group selected from alkyl, aryl, allyl, alkoxy, cycloalkyl, he...
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JP4474745B2 |
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JP4469179B2 |
Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by R...
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JP4461048B2 |
A short practical commercial process for the efficient enantioselective synthesis of the non-steroidal antiestrogen of formula (I) or (XIV) or a pharmaceutically acceptable salt thereof.
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JP2010513531A |
The present invention discloses processes for the preparation and isolation of the individual stereoisomers of 1-amino, 3-substituted phenylcyclopentane-carboxylates.
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JP4450399B2 |
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JP4437648B2 |
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JP4437012B2 |
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JP4434614B2 |
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JP2010507574A |
The invention relates to an insect- and mite-repelling agent, characterized by a content of at least one substituted, enantiomer-enriched α-,ω-amino alcohol derivative of formula (1) wherein X represents hydrogen, COR11 or R13, R13 rep...
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JP2010053149A |
To provide a purification method for a latanoprost and a high-purity latanoprost.The method for purifying the latanoprost is conducted by HPLC characterized by use of a mixture containing one ore more hydrocarbons, one or more alcohols, ...
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JP4425632B2 |
In one embodiment, the present invention describes the synthesis of 4-(piperidyl) (2-pyridyl)methanone-(E)-O-methyloxime dihydrochloride, monohydrochloride and free base, and similar compounds, in high stereochemical purity.
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JP2010504978A |
3-phosphoindole compounds substantially in the form of a single enantiomer useful for the treatment of Flaviviridae virus infections, and particularly for HIV infections are provided. Also provided are pharmaceutical compositions compris...
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JP4415543B2 |
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JP4405675B2 |
A method for crystallizing the maleic acid salt of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl-L-proline (Enalapril) from an aqueous liquid with ease in good yield, which comprises mixing an aqueous liquid containing N-(1(S)-ethoxyca...
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JP4406483B2 |
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JP4406482B2 |
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JP4399769B2 |
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JP4397987B2 |
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JP4392661B2 |
When a salt of an amine and an optically active diacyltartaric acid, or a diastereomer salt of an optically active amine and an optically active diacyltartaric acid, obtained by optically resolving a racemic amine using the optically act...
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JP4389683B2 |
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JP2009544656A |
The present invention relates to a process for the preparation of levetiracetam and, more particularly, to an improved process for the preparation of levetiracetam characterized by a crystallization-induced dynamic resolution of a diaste...
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JP2009543759A |
The present invention relates to a novel process for the preparation of polymorphic forms of clopidogrel hydrogen sulfate, namely methyl(+)-(S)-alpha-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c
]pyridine-5(4H)-acetate hydrogen sulfate of fo...
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JP4380325B2 |
The invention provides a process for producing optically active 2, 2-dimethylcyclopropanecarboxylic acid by reacting an optical isomer mixture of 2,2-dimethylcyclopropanecarboxylic acid with an optically inactive amine to form (precipita...
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JP4381137B2 |
The compound 3-{(3R,4R)-4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-
yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile or a pharmaceutically acceptable salt thereof; compositions containing the compound; and uses of the compound in the...
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JP2009542590A |
The present application relates to novel substituted benzoxepinoisoxazole derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment...
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JP2009542728A |
The invention provides compounds of formula (I) having (-) or (+) configuration, or pharmaceutically acceptable salts thereof, wherein R 1 is H or halo; R 2 is CF 3 , CN, or halo; R 3 is linear or branched alkyl having 1 to 6 carbon atom...
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JP4377219B2 |
The invention relates to a process for the preparation of racemic citalopram free base or an acid addition salt thereof and/or R- or S-citalopram as the free base or an acid addition salt thereof by separation of a mixture of R- and S-ci...
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JP2009541282A |
The present invention relates to a 1,5-diphenylpyrazole compound and its use in the treatment of obesity, psychiatric and neurological disorders, to methods for the its therapeutic use and to pharmaceutical compositions containing them.
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JP4373933B2 |
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JP4372873B2 |
Production of optionally (1S,4R)- or (1R,4S)-1-amino-4-(hydroxymethyl)-2-cyclopentene (VII) or (VIII) (or their salts) involves biotechnological optical resolution of racemic 1-amino-4-(hydroxymethyl)-2-cyclopentene (I) using a hydrolase...
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JP2009539771A |
The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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JP4365602B2 |
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JP2009538831A |
The present invention relates to intermediates of rosuvastatin and processes for the production thereof.
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JP4362517B2 |
The present invention relates to the isomerization of the Z-isomer I-Z of semicarbazone compounds of the general formula (I) into its E-isomer I-E, where the variables in formula (I) have meanings given in claim 1
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