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JP4834333B2 |
A benzylamine derivative has a structure represented by the following formula (1): In a method for optical resolution of the benzylamine derivative, optically active mandelic acid is used as an optical resolving agent. In an optical reso...
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JP4836897B2 |
PCT No. PCT/EP96/00773 Sec. 371 Date Sep. 2, 1997 Sec. 102(e) Date Sep. 2, 1997 PCT Filed Feb. 24, 1996 PCT Pub. No. WO96/27615 PCT Pub. Date Sep. 12, 1996The present invention relates to photochemically cross-linked derivatives of gener...
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JP2011241191A |
To provide a method for producing an optically active alcohol in high yield with high enantio-selectivity from a ketone compound.The method for producing an optically active alcohol includes a step of allowing a ketone compound to react ...
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JP4825825B2 |
The invention provides a novel, crystalline polymorphic form of (-)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phe
nyl]hydrazono]propanedinitrile and a method for making the polymorph. The compound is useful as a cardiotonic ag...
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JP4816454B2 |
The present invention is a method for separately collecting an optically active amino acid amide and an optically active amino acid from an aqueous solution containing the optically active amino acid amide and the optically active amino ...
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JP4812434B2 |
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JP2011219419A |
To provide a triazole compound exhibiting remarkably excellent noxious organism-controlling activity and to provide (+)-1-[2,4-dimethyl-5-(2,2,2-trifluoroethylsulfinyl)phenyl]-
3-(trifluoromethyl)-1H-1,2,4-triazole.The optically active (...
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JP4800213B2 |
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JP4797251B2 |
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JP2011526614A |
There is described a process for the manufacture of a racemic 2-aryl propionic acid compound, or a pharmaceutically acceptable salt thereof, which comprises reacting the S- or R-enantiomer of the corresponding 2-aryl propionic acid compo...
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JP4790128B2 |
A novel (−)-enantiomer of 2-[2-(1-chloro-cyclopropyl)-3-(2-chloro-phenyl)-2-hydroxypro
pyl]-2,4-dihydro-[1,2,4]-triazole-3-thione of the formula a process for preparing this novel active compound and its use as microbicide in crop prot...
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JP4787795B2 |
Preparation of an amino-hydroxy-propionamide compound (I) comprises reacting an epoxy carboxylic acid amide compound (II) with an ammonia or an amine compound (III). JP2007332309AJP2007332309APreparation of an amino-hydroxy-propionamide ...
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JP4783496B2 |
Provided is a separating method for an optical isomer mixture comprising the steps of mixing an amino acid derivative such as N-(tert-butoxycarbonyl)-DL-alanine in which optical isomers of a D type and an L type are present in a mixture ...
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JP4780536B2 |
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JP2011183361A |
To provide a new separator usable as a separator for chromatography and carrying a cyclic oligosaccharide.The separator is prepared by carrying on a carrier the cyclic oligosaccharide comprised of a repeating unit of a D-glucopyranoside ...
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JP4776846B2 |
A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are des...
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JP4778178B2 |
A methods of preparing a substantially pure enantiomer of an acylanilide such as Casodex(R) (bicalutamide) and/or its derivatives includes resolving an intermediate compound having the structure of Formula I:whereinR1 is alkyl or haloalk...
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JP2011524909A |
The present invention is directed to practical high-yielding synthetic processes to prepare compounds of general Formula III, IV, V, VII, VIII, IX, X, XII, XIV, and XV. Such compounds are useful as final products or can be used as interm...
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JP2011524907A |
Disclosed is crystalline R(+)-N-propargyl-1-aminoindan containing water at an amount of less than 0.5% by weight and a pharmaceutical composition comprising the same, and the process for the manufacture and the validation thereof. Also d...
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JP4768145B2 |
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JP4769562B2 |
It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula (I) containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an o...
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JP4768638B2 |
The present invention relates a process for stereoselective or regioselective chemical synthesis which generally comprises reacting a nucleophile and a chiral or prochiral cyclic substrate in the presence of a non-racemic chiral catalyst...
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JP4768953B2 |
Bis(cis-3,3,5-trimethylcyclohexyl) phthalate includes stereoisomers represented by following Formulae (1), (2) and (3) and satisfies the following conditions:wherein a, b and c are mole percentages of the stereoisomers represented by For...
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JP4761769B2 |
A process for easily producing an optically active beta -amino alcohol useful as a pharmaceutical intermediate from an inexpensive, readily available starting material is provided. A readily available alpha -substituted ketone is reacted...
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JP4763771B2 |
The present invention relates to a method for preparing optically active 3-phenylpropionic acid derivatives, to optically active 1-chloro-3-phenylpropane derivatives obtainable therefrom and to optically active intermediates obtained the...
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JP4754753B2 |
Ferrocene anchored chiral ligands and metal complexes based on such chiral ligands useful in asymmetric catalysis are disclosed. The metal complexes according to the present invention are useful as catalysts in asymmetric reactions, such...
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JP4752285B2 |
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JP4750265B2 |
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JP4747320B2 |
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JP4745655B2 |
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JP2011144162A |
To provide a new crystal of an optically active 4-amino-3-(4-chlorophenyl)butanoic acid, and a method for producing the same.This method for producing the following crystal A, comprising a process of heating the following crystal B in wa...
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JP4735263B2 |
There is provided a process for producing an optically active 2-alkylcysteine or a salt thereof, characterized by allowing cells of microorganism or treated products thereof having an activity of stereoselective hydrolysis of the amide b...
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JP4728548B2 |
An industrially advantageous process for producing optically active 4-amino-2-methylbutane-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic 4-amino-2-methylbutane-1-ol is treated ...
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JP4728636B2 |
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JP4723245B2 |
Process for the preparation of primary amines of formula (I): where R3 represents an alkyl, cycloalkyl or aralkyl group, by reaction of a triazolium salt of formula (II): where R1 and R2 represent hydrogen or an alkyl, aralkyl or aryl gr...
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JP4719471B2 |
Production of crystalline forms (specifically polymorphic forms or solvates) of enantiomers of modafinil (A) involves dissolving an enantiomer of (A) (preferably the levorotatory isomer, (-)-(A)) in a solvent other than ethanol, crystall...
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JP2011126825A |
To provide an industrially practicable method for producing optically active L- or D-tert-leucinamide important as a raw material for a medicine or an agrochemical in excellent operability.The optical purity of the tert-leucinamide in a ...
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JP4694837B2 |
The present invention relates to a novel method for the preparation of diol intermediates useful for the preparation of escitalopram involving selective enzymatic acylation or deacylation.
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JP2011102295A |
To provide a method for efficiently synthesizing (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-
phenol isobutyrate (Fesoterodine) and its (S)-enantiomer fesoterodine, by which the synthesis of the Fesoterodine and its (S)-e...
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JP2011093924A |
To provide a pharmaceutical composition containing a venlafaxine derivative free of the harmful effects such as hypertension and a headache, which racemic venlafaxine [chemical name: (±)-1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyc...
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JP2011513469A |
A stereoselective and enrichment process for the preparation of ciclesonide is described.
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JPWO2009075359A1 |
The chiral substance C is irradiated with light such as circularly polarized light to form an isomer (C).1, C2In order to realize a method for separating isomers of a chiral substance that does not use a chemical reaction in a non-contac...
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JP4675938B2 |
N-[3-Hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide (I), its enantiomers and base addition salts, are new. N-[3-Hydroxy-2-(7-methoxy-1-naphthyl)propyl] propanamide of formula (I), its enantiomers and base addition salts, are new. An...
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JP4676064B2 |
The invention relates to a novel process for the preparation of certain pharmaceutically active pyridyl compounds.
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JP2011079782A |
To provide a method for producing a new diastereomer salt containing optically active 1-amino-2-propanol, and a method for efficiently isolating the optically active 1-amino-2-propanol from the synthesized new diastereomer salt, and also...
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JP2011074084A |
To provide a method of industrial-scale purification of lactic acid, and to provide chirally extremely pure products obtained via this method and the use thereof.The method includes the steps of: (a) reduced-pressure distillation of a co...
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JP2011509933A |
A novel scalable synthesis for the preparation of 7-(3-pyridinyI)-1,7-diazaspiro[4.4)nonane has been developed, and 7-(3-pyridinyl)-1,7-diazaspiro[4.4]nonane salts have been formed with succinic acid and oxalic acid. Additionally, 7-(3-p...
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JP4661272B2 |
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JP4662950B2 |
The present invention relates to the field of perfumery and concerns a diether or a 1,3-dioxolane derivative of 1,8a-methano-2,4a,8,8-tetramethyldecahydro-2,3-naphthalenedi
ol and its use as perfuming ingredient. The present invention co...
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JP2011057612A |
To provide a practical method for producing optically active adamantyloxypropionic acid.The method for producing optically active adamantyloxypropionic acid comprises: a step of reacting 2-(1-adamantyloxy)propionic acid with an amine sel...
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