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JP4361641B2 |
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JP4361094B2 |
The present invention is concerned with the resolution of a mixture of enantiomers of N-protected amino acids by crystallization with enantiomerically pure N-unprotected β-amino acid derivatives.
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JP2009538277A |
The present invention provides 2-azetidinone derivatives, or pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof, comprising formula (I): wherein the substituents are as herein defined. The compounds ...
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JP2009538343A |
A 5(S)-(2'-hydroxyethoxy)-20(S)-camptothecin diastereoisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2'-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2'-hydroxyethoxy...
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JP2009256298A |
To provide a method for obtaining 3-aminopiperidine of high optical purity.In an optical resolution method for a piperidin-3-ylcarbamate compound, an RS mixture of a piperidin-3-ylcarbamate compound represented by formula (1) (in the for...
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JP4359796B2 |
An optical resolver comprising an optically active substance made of tris-(2,3-epoxypropyl)isocyanurate, is presented. The optical resolver comprises an optically active tris-(epoxyalkyl)isocyanurate or its derivative, or an optically ac...
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JP4356060B2 |
To provide an industrial method for efficiently producing an optically active 1-protected indoline-2-carboxylic acid derivative. A racemic 1-protected indoline-2-carboxylic acid derivative is optically resolved with an optically active d...
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JP2009227684A |
To provide a new method for producing a racemic form or an optically active form of an amino alcohol expressed by formula I, starting from 2-azabicyclo[2.2.1]hept-5-ene-3-one, a method for converting the above to a corresponding acyl der...
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JP2009227685A |
To provide a new method for producing a racemic form or an optically active form of an amino alcohol expressed by formula I, a method for converting it to a corresponding acyl derivative and a method for further converting the above to (...
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JP4339074B2 |
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JP4338979B2 |
The invention relates to a method for producing biperiden which is characterized in that an exo/endo mixture of 1-(bicyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is reacted with an isomer ratio of the exo form to the endo form of...
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JP2009221215A |
To provide a new method for producing a racemic body or an optically active body of an aminoalcohol of formula I, starting from 2-azabicyclo[2.2.1]hept-5-en-3-one, a method for further converting it to the corresponding acyl derivative t...
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JP4335314B2 |
Microorganisms (A), or their enzymatic extracts, able to utilise cyclopentene derivatives (VII) as sole carbon (or carbon and nitrogen) source are new. R1 = 1-4C alkyl or alkoxy, or aryl or aryloxy. Also new are (1) N-acetylamino-alcohol...
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JP4334654B2 |
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JP2009532354A |
This invention relates to relates to methods for producing gossypol acetic acid co-crystals and (-)-gossypol acetic acid co-crystals. The invention also relates to pharmaceutical compositions comprising gossypol acetic acid co-crystals a...
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JP4326614B2 |
A process for the manufacture of bisphosphine oxide compounds and bisphosphonates as intermediates for the production of bisphosphine ligands, in which in a single step process a) a phosphine oxide compound is reacted in an organic solve...
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JP2009531315A |
This invention relates to a process for preparing a compound of Formula 1 wherein: the carbon atoms alpha and beta to the carboxy group are stereocenters; R 1 is independently H, optionally substituted aliphatic, optionally substituted c...
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JP4324593B2 |
Disclosed herein are novel binaphthol derivatives and methods for the optical resolution of amino acids or amino alcohols and for the optical transformation of D, L-forms of amino adds using the same.
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JP4320068B2 |
The invention provides separating agents for optical isomers which have a high optical resolving power inherent in polysaccharide derivatives and high solvent resistance, and which can be produced through short process steps; a process f...
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JP4319847B2 |
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JP4320065B2 |
The present invention provides a method for separating optical isomers, which enables the optical resolution of compounds which could not sufficiently be resolved optically by the reversed-phase chromatographic methods of the prior art. ...
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JP4320870B2 |
PURPOSE: To provide a method for manufacturing (+)-trans chrysanthemic acid I that can produce the chrysanthemic acid with more industrial advantage. CONSTITUTION: This production process for (+)-trans chrysanthemic acid I is characteriz...
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JP4314740B2 |
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JP2009529024A |
The present invention relates to a process for the enantiomeric enrichment of salbutamol and salbutamol precursors and the acid-addition salts thereof: where R is hydrogen or benzyl, R' is hydrogen or benzyl and X is CH 2 OH or COO-C 1 -...
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JP4309971B2 |
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JP4303785B2 |
The title compounds are obtained by racemate resolution of D,L-homoalanin-4-yl(methyl)phosphinic acid via precipitation of one of the diastereomeric salts using chiral bases such as quinine or cinchonine. It is possible to increase the y...
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JP4306296B2 |
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JP4301004B2 |
The present invention provides a method of kinetic optical resolution of carboxylic acid derivatives using specific optically active catalysts. A racemic or diastereomeric mixture of carboxylic acid derivatives of the formula (A) is reac...
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JP4297994B2 |
6-Hydroxy and 6-oxo-androstane derivatives having the general formula (I): wherein the symbol @ represents a single or a double bond and A, R<1> and R<2> have the meanings given in the description; a pharmaceutical composition comprising...
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JP2009525320A |
A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiome...
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JP4293792B2 |
The present invention provides a separating agent for enantiomeric isomers, which has an excellent ability to identify asymmetry. That is, the present invention relates to a separating agent for enantiomeric isomers which includes as an ...
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JP4282604B2 |
Preparation of optically active 5-hydroxy-3-ketoalkanoic acid ester derivatives (I) comprises subjecting the corresponding racemic mixture of compounds (II) to preparative high performance liquid chromatography (HPLC) on a chiral carrier...
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JP2009132621A |
To provide a method for efficiently producing 3-amino-2-hydroxyhexanoic acid cyclopropylamide, suitable for industrial production, to provide an intermediate compound useful for the production method, and to provide a method for producin...
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JP4275737B2 |
The invention essentially relates to thermally crosslinked polysaccharide derivatives which contained no polymerizable functional groups prior to crosslinking and which are used in particular as support materials for the chromatographic ...
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JP2009120611A |
To efficiently provide enantiomerically-pure azetidine-2-carboxylic acid.The enantiomerically-pure azetidine-2-carboxylic acid is produced by (a) selective crystallization of a diastereomerically-pure azetidine-2-carboxylic acid-tartrate...
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JP4273528B2 |
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JP2009520753A |
The present invention relates to a process for preparing a specific alpha-chiral chloromethyl compound in pure or enriched form by distillative removal of the compound mentioned from substance mixtures which comprise this compound and hi...
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JP2009114065A |
To provide a method for producing (2R,3R) and (2S,3S)-3-phenylisoserine derivatives useful as intermediates of medicines, simply and industrially advantageously.It is possible to remove regioisomers as byproducts efficiently by reacting ...
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JP2009519938A |
The present invention is directed to a process for the isolation of (R)-tofisopam with high enantiomeric purity and high overall yields from a mixture of tofisopam enantiomers by means of a non-steady state continuous chromatographic pro...
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JP2009519325A |
The present invention relates to more improved process for preparing 2'-deoxy-2',2'-difluoronucleoside and its intermediate. The present invention provide a process for preparing an erythro enantiomer in greater than 98% purity, comprisi...
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JP2009518416A |
A configurable multimedia SIP client and method are disclosed. As one example, a configurable multimedia SIP client is disclosed, which includes a client user interface, a call processing configuration manager, and a configuration adapto...
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JP4258031B2 |
The present invention provides a novel beta -diketone compound represented by formula (3): wherein X represents (CH2)n; n represents an integer of 2-20; and the CH2 of X may be replaced by an oxygen atom, a hetero ring, or an aromatic ri...
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JPWO2007055180A1 |
The present invention has the general formula (1). [Chemical 1](In the formula, R1Indicates a group selected from a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxyl group, and a nitro group. Also, * me...
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JP4258788B2 |
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JP2009516701A |
The present invention relates to a process for the synthesis of (S)-2'[2-1-(methyl-2-piperidyl) ethyl] cinnamanilide (I) or salts or pharmaceutically acceptable prodrugs thereof:
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JP4257573B2 |
Process for the synthesis of R(+)alpha-lipoic acid comprising the following stages: a) Salifying of racemic thioctic acid with R(+)alpha-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt of R(+)alp...
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JP4257574B2 |
Process for the synthesis of R(+)alpha-lipoic acid comprising the following stages: a) Salifying of racemic 6,8-halo-octanoic acid with S(-)alpha-methylbenzylamine; b) separation by filtration of the crystallized diastereoisomeric salt o...
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JP4249135B2 |
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JP2009513591A |
The invention relates to a process for preparing chiral octenoic acid derivatives, which constitute important intermediates in the preparation of medicament active ingredients, and also to novel intermediates which are used in the proces...
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JP4244364B2 |
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