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WO/2018/207694A1 |
A 1–amino cyclopropane carboxylic acid nonhydrate can be produced as a result of: using a tertiary amine to treat a 1–amino cyclopropane carboxylic acid hydrochloride in the presence of a C3–C4 alcohol and water; maintaining the re...
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WO/2018/208754A1 |
This invention relates to compositions and methods for treating or ameliorating symptoms of a neuropsychiatric disease in a subject in need thereof comprising: (a) a therapeutically effective amount of propofol; and (b) a therapeutically...
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WO/2018/208677A1 |
Embodiments of the present disclosure are related to improved processes for making L-ornithine phenylacetate without using any silver salts or forming any L-ornithine intermediate salts, such as a benzoate salt. The present processes may...
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WO/2018/204434A1 |
The present disclosure is related to the field of agrochemicals, including compound I and its use to control fungal diseases in agriculturally useful row crops.
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WO/2018/204438A1 |
The present disclosure is related to the field of agrochemicals, including compound I and its use to control fungal diseases on turfgrasses.
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WO/2018/204435A1 |
A fungicidal composition containing a fungicidally effective amount of the compound of Formula I, (S)-l,l-bis(4-fluorophenyl)propan-2-yl (3-acetoxy-4-methoxypicolinoyl)-L- alaninate, and at least one fungicide selected from the group con...
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WO/2018/204437A1 |
A fungicidal composition containing a fungicidally effective amount of the compound of Formula I, (S)-1,1-bis(4-fluorophenyl)propan-2-y1 (3-acetoxy-4-methoxypicolinoy1)-L-alaninate, and at least one fungicide selected from the group cons...
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WO/2018/204869A1 |
The present invention relates to conjugates including a chelating moiety of a metal complex thereof and a therapeutic or targeting moiety, methods for their production, and uses thereof.
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WO/2018/204431A1 |
The present disclosure relates to the use of the compound of Formula I, (S)-1,1-bis(4- fluorophenyl)propan-2-yl (3-acetoxy-4-methoxypicolinoyl)-L-alaninate, as a seed treatment to prevent or control plant diseases.
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WO/2018/204436A1 |
A fungicidal composition containing a fungicidally effective amount of the compound of Formula I, (S) -1,1-bis (4-fluorophenyl)propan-2-yl (3-acetoxy-4-methoxypicolinoyl)-L-alaninate, and at least one fungicide selected from the group co...
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WO/2018/204433A1 |
The present disclosure is related to the field of agrochemicals, including compound I and its use to control fungal diseases in agriculturally useful orchard, vineyard and plantation crops.
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WO/2018/204432A1 |
The present disclosure is related to the field of agrochemicals, including compound (I) and its use to control fungal diseases in agriculturally useful vegetable crops.
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WO/2018/197475A1 |
The present invention provides processes for preparing a compound of formula (I) and pharmaceutically acceptable salts thereof, comprising deprotecting a compound of formula (II), wherein each R3 independently represents a tertiary alkyl...
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WO/2018/176150A1 |
Novel methods for isolating fish roe/egg extracts, notably a coagulum and a sediment extract, enriched in phospholipids and omega-3 fatty acids are described. Novel compositions comprising omega-3 polyunsaturated fatty acids and micronut...
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WO/2018/174826A1 |
This invention relates to a method for producing an alkenyl 1 -aminocyclopropane-1 -carboxylic acid of Formula I wherein R1 is a protecting group, n is an integer between 1 and 10, and A and B are chiral centres such that when A is S, B ...
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WO/2018/170322A1 |
Provided herein are novel solid forms of each of four compounds: (1) heptadecan-9-yl 8-((2-hydroxyethyl)amino)octanoate ("Compound 1"), (2) heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoat
e ("Compound 2"),(3)...
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WO/2018/170306A1 |
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions fu...
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WO/2018/165120A1 |
Methods of treating obesity symptoms, metabolic disorders or lipodystropy by administering carboxyalkylethers, in particular 6,6'-oxybis-(2,2'-dimethylhexanoic acid) or an ester, hydrate or salt thereof.
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WO/2018/164662A1 |
A resveratrol ester has the following structure: (I). R1, R2 and R3 are H or (II). Each R4 is independently a carbon chain of 2 to 4 carbon atoms comprising a terminal carboxylic acid moiety, a carbon chain of 1 to 5 carbon atoms compris...
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WO/2018/157842A1 |
The present invention provides a use of 2-(substituted phenylamino)benzoic acid FTO inhibitor in treating leukemia.
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WO/2018/157843A1 |
The preparation method provides 2-(substituted benzene matrix) aromatic formate FTO inhibitor, a preparation method therefor, and applications thereof. Specifically, disclosed in the present invention are a 2-(substituted benzene matrix)...
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WO/2018/153876A1 |
Process for making solid methylglycine diacetate (MGDA) alkali metal salt (a), said process comprising the steps of (A) providing a 35 to 60% by weight aqueous solution of said MGDA salt having a temperature in the range of from 50 to 90...
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WO/2018/150906A1 |
This liquid crystal display device 10 is provided with: a pair of substrates which have conductive films 14, 15, respectively; a liquid crystal layer 12 which is arranged between the pair of substrates and contains liquid crystals; and a...
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WO/2018/145553A1 |
The present disclosure provides co-crystals of a substituted glycine compound and a co-former compound of Formula (I), compositions comprising such, and uses thereof in treating and/or reducing the risk for a neuropsychiatricdisorder (e....
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WO/2018/148380A1 |
Methods of treating a seizure disorder with (1S,3S)-3-amino-4-(difluoromethylidene)cyclopentane-1-carbox
ylic acid, or (S)-3-amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxyl
ic acid (KT-II-115), or a pharmaceutically acceptable sal...
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WO/2018/139311A1 |
[Problem] To provide a novel diamine compound with which it is possible to synthesize a polyimide compound having high solubility in organic solvents and high melt moldability. [Solution] This diamine compound is characterized by being r...
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WO/2018/132066A1 |
Disclosed are compounds having the following formula: (I) wherein R is an alkane chain having between 8 and 20 carbon atoms, and A is one or more anions having a total charge of -2; or R is a quaternary amine having the following formula...
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WO/2018/116203A1 |
The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, ...
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WO/2018/115434A1 |
The invention relates to a method for the production of acetylsalicylic acid lysinate, optionally lysine acetylsalicylate · glycine, comprising the following steps: a) providing a solution of acetylsalicylic acid in ethanol; b) providin...
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WO/2018/118838A1 |
Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with the en...
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WO/2018/107158A1 |
This present disclosure is directed to compounds of formula (I): where r, q, R1a, R1b, R1c, R1d, R1e, R2, R3, R4a, R5a, R5b, R6a, R6b, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceu...
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WO/2018/101329A1 |
The purpose of the present invention is to develop a therapeutic agent for inflammatory diseases such as inflammatory bowel disease and NASH, said therapeutic agent having few adverse effects and high efficacy. The present invention prov...
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WO/2018/096504A1 |
Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R1 and R2 a...
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WO/2018/097431A1 |
The present invention provides a composition for protecting the skin from heavy metals and formaldehyde, comprising at least one selected from the group consisting of trientine or trientine derivative of Formula (1), cyclen or cyclen der...
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WO/2018/090963A1 |
The invention provides a method for preparing a lisinopril intermediate, comprising: treating (R)-hydroxy-4-phenylbutyrate with sulfonyl chloride in an organic solvent in the presence of a base to obtain a solution of sulfonate; reacting...
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WO/2018/090670A1 |
The present invention relates to a method for preparing a droxidopa intermediate (2S,3R)-3-(3,4-dibenzyloxyphenyl)-2-dibenzylamino-3-hydroxyp
ropionate, comprising carrying out asymmetric hydrogenation to 3-(3,4-dibenzyloxyphenyl)-2-dibe...
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WO/2018/087753A1 |
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their int...
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WO/2018/087064A1 |
The invention relates to a method for producing triarylorganoborates from organoboronic acid esters in the presence of an n-valent cation 1/n Kn+, comprising the anhydrous treatment of the reaction mixture, and to the use of the obtained...
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WO/2018/086053A1 |
The present invention discloses a γ-aminobutyric acid semihydrate crystal. The formula of the crystal is C4H9NO2·0.5H2O. The present invention further discloses a preparation method for the γ-aminobutyric acid semihydrate crystal, whe...
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WO/2018/082096A1 |
Provided are a new γ-propalanine crystal form and a preparation method therefor. The method comprises steps of: S1: adding a crude γ-propalanine into water to prepare a γ-propalanine solution having an initial concentration of 0.5 to ...
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WO/2018/085578A1 |
The present disclosure provides combinations of a VLA-4 inhibitor and an agent which interacts with a chemokine receptor, and methods of use thereof. In some embodiments, the disclosed combinations may be used in a method of mobilizing h...
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WO/2018/078053A1 |
The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formu...
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WO/2018/081372A1 |
Embodiments of the present disclosure provide for methods of treating cancer (e.g., leukemia), pharmaceutical compositions for treating cancer, methods of modulating cancer progression and development, and the like.
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WO/2018/080869A1 |
Methods of making polyamides from renewable materials, such as natural oils, are generally disclosed herein. In some embodiments, the polyamides are nylon-10. In some such embodiments, nylon-10 is made by polymerizing 10-aminodecanoic ac...
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WO/2018/068757A1 |
New anticancer and anti-obesity agents based on the cyclic peptide compounds are disclosed, and its preparation and application method for treating cancer and obesity diseases are also disclosed.
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WO/2018/067401A1 |
Eflornithine is an agent that can be used to treat glioma, especially glioma of WHO Grade II or Grade III such as anaplastic glioma. Eflornithine can suppress or prevent mutations in glioma which can cause the glioma to progress to a hig...
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WO/2018/064755A1 |
A transfection reagent composition comprising: 30-60MOL% of an cationic lipid, or pharmaceutical acceptable salt thereof; 10-60 MOL% structural lipid; a sterol and 0.1 to about 10MOL% of a stabilizing agent is provided. The reagent is pa...
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WO/2018/059279A1 |
Disclosed is a method for synthesizing a novel chiral ligand, a metal chelate, a variety of non-natural amino acids, Maraviroc and a key intermediate thereof. In the invention, (R)-2-methyl proline is selected and used as a starting raw ...
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WO/2018/059427A1 |
Disclosed is a method for preparing 2-(2-(4-fluorobenzoyl)phenylamino)-3-(4-(2-(9H-carbazol-9-yl
)ethoxy)phenyl)propanoic acid. In the method 9-carbazole ethanol mesylate and methyl 2-[2-(4-fluorobenzoyl)phenyl)amino]-3-(4-hydroxyphenyl)...
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WO/2018/057290A1 |
The invention relates to a method for synthesizing amino acids or amino acid derivatives involving cross metathesis of functionalized olefins and a tandem amination-reduction process. Amino acids and amino acid derivatives present many i...
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