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JPH10509715A |
18,19-dinor-vitamin D3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring and the exocyclic methylene group attached to carbon 10 of the A-ring have been removed and replaced by a hydrogen atom. The 18,19-dino...
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JPH10509716A |
18-nor-vitamin D3 analogs in which the angular methyl group attached to carbon 13 of the CD-ring has been removed and replaced by a hydrogen atom. The 18-nor vitamin D compounds are characterized by relatively high cell differentiation a...
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JP2801587B2 |
The invention relates to a compound of the formula wherein R is hydroxy and R<1> is H2 or CH2, or R is hydrogen or fluoro and R<1> is CH2. Compounds of formula I are useful as agents for the treatment of hyperproliferative skin diseases,...
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JP2793428B2 |
PURPOSE: To obtain a compd. useful for the treatment of leukemia and the like by a new and improved method by which a specified tosylate is reduced by a reducing agent such as LiAlH4 and deblocking the produced hydroxy protected pregnaho...
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JP2782244B2 |
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JPH10182597A |
To obtain an isomerized vitamin D derivative capable of separating a main effect and a side effect and enlarging a safety zone as a medicine by reversing configuration of hydroxide at 1-position or 3-position, or allowing the 3-position ...
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JPH10506374A |
A method for 1 alpha -hydroxylation of vitamin D compounds using the appropriate vitamin D as the starting material. The method requires no separatory procedures prior to the actual hydroxylation step.
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JP2760514B2 |
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JPH10139711A |
To obtain the subject compound useful as an intermediate for producing a therapeutic agent for dermatosis, by irradiating a specific provitamin D3 derivative with ultraviolet rays, separating an unreacted substance and thermally isomeriz...
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JP2752509B2 |
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JP2752506B2 |
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JP2752508B2 |
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JP2752507B2 |
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JPH10101694A |
To obtain a novel subject compound which comprises a steroidal compound of a specific structure and is useful as a synthetic intermediate for activated type vitamin D derivative having excellent bode mass improvement, differentiation ind...
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JP2741497B2 |
The invention relates to ring A-diol units suitable for synthesizing 1 alpha -hydroxyvitamin D compounds by subsequent condensation with appropriate C/D-ring fragments and to methods for preparing such ring A-diol units.
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JPH1087495A |
To obtain a medicinal agent containing a specific vitamin D(s) as active ingredient, and useful for preventing/treating diseases due to RANTES production such as acidocytosis, bronchial asthma and nasal allergy. This medicinal agent cont...
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JP2731839B2 |
This invention relates to hydroxylated derivatives of vitamin D2 and a process for preparing such compounds. In particular, a process for preparing the 24-epimer of vitamin D2 and the corresponding 1 alpha -hydroxylated derivative thereo...
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JP2710789B2 |
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JP2711161B2 |
PCT No. PCT/DK89/00079 Sec. 371 Date Oct. 10, 1990 Sec. 102(e) Date Oct. 10, 1990 PCT Filed Apr. 7, 1989 PCT Pub. No. WO89/10351 PCT Pub. Date Nov. 2, 1989. (I) The present invention relates to compounds of formula (I), in which formula,...
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JP2708126B2 |
Anti-ulcer agents containing isoprenoid derivatives are provided. The isoprenoid derivatives are represented by the formula: Wherein: R represents a group of formula In the above formula, R1, R2 and R3 may be the same or different each o...
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JP2699766B2 |
PURPOSE: To provide a new fluoride analog of vitamin D3 having excellent pharmacologic action, especially antitumor activity caused by the action to induce the cell differentiation from tumor cell to normal cell. CONSTITUTION: The compou...
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JP2699765B2 |
PURPOSE: To provide the subject new fluorine-containing vitamin D3 analogs showing a high selectivity in their actions, low in side effects and especially exhibiting an antineoplastic effect equal or higher than in vitamin D3 related com...
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JP2695473B2 |
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JP2677520B2 |
The invention relates to the compounds 1,25-dihydroxy-16-ene-24-oxo-cholecalciferol and 1,24,25-trihydroxy-16-ene-cholecalciferol which stimulate differentiation of HL-60 cells, rendering them useful as an agent for the treatment of neop...
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JP2670005B2 |
PURPOSE: To provide a new compd. which is useful as pharmaceutics for the treatment of hyperproliferactive disorders of skin, cancer, leukemia and diseases in sebaceous glands. CONSTITUTION: This compd. is expressed by formula I (R is H,...
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JP2670545B2 |
This invention relates to the novel processes for the preparation of a 16-methoxy-16-methyl prostaglandin E1 derivative and to the novel intermediates useful therefor.
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JP2668759B2 |
PURPOSE: To obtain a new intermediate compd. effective to introduce a side chain unit and usable effectively to synthesize a broad range of 1α-hydroxy-19- nor-vitamin D compds. CONSTITUTION: The intermediate compd. is a compd. of formul...
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JP2667875B2 |
This invention encompasses a process for preparing higher order cuprate complexes which contain a carbanion for the formation of carbon to carbon bonds in reactions such as 1,4-conjugate addition. The complex is formed by reacting a firs...
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JP2664667B2 |
A method of treating psoriasis in a patient which comprises administering to said patient an effective amount of a vitamin D compound which is capable of stimulating the differentiation of cultured tumor cells or normal rodent or human f...
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JP2659345B2 |
PURPOSE: To provide a fluorinated vitamin D3 derivative which inhibits the proliferation of human sebaceous gland cells useful as an agent for the treatment of acne. CONSTITUTION: A desired fluorinated vitamin D3 is 1α-fluoro-25-hydroxy...
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JP2658574B2 |
Fluorine-containing vitamin D3 analogues of the formula: [I] wherein R1, R2 and R3 are independently hydrogen atom, a hydroxy-protecting group, having excellent pharmacological activities, such as tumor cell differentiation-inducing acti...
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JPH09249641A |
To obtain a new subject compound having calcium regulating action in vivo and differentiation-inducing action of tumor cells, expected for improving action of bone amount and having no adverse effects. This fluorinated vitamin D derivati...
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JP2648845B2 |
PURPOSE: To easily obtain a compd. of the purpose useful as a therapeutic drug for malignant tumor by the reaction of Windaus Grundmann ketone and lithium anion of phosphine oxide. CONSTITUTION: A compd. expressed by formula I [X1, X2 ar...
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JPH09221450A |
To obtain an anti-inflammatory composition comprising a new compound having an antagonism against protein kinase C and useful as an anti- inflammatory agent, an anti-cancer agent, an anti-leukemia agent, an anti- asthmatic agent, an anti...
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JP2645130B2 |
(24S)- and (24R)-1 alpha ,25-Dihydroxyvitamin D4 compounds and processes for preparing same. Ergosta-5,7-diene compounds which are useful intermediates in the synthesis of the 1 alpha ,25-dihydroxyvitamin D4 compounds. The D4 compounds a...
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JP2642189B2 |
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JP2642190B2 |
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JP2640359B2 |
According to this process a stereospecific reduction of the two hydroxyl groups of an etherdiol is carried out using a mixture (titanium trichloride, lithium aluminium hydride) at a temperature of approximately between 5 DEG C and 40 DEG...
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JPH09507480A |
An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 wher...
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JP2620558B2 |
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JP2616351B2 |
PURPOSE: To provide the subject new compounds exhibiting a calciumregulation effect in the body and a differentiation-inducing effect on neoplastic cells. CONSTITUTION: Compounds of formula I (R1 is H and H2 is OH; or, R1 is OH and R2 is...
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JPH09143154A |
To simply produce a mass-producible vitamin D3 derivative in good yield by using a hydroxyvitamin D3 derivative available in a large amount as a starting raw material. A compound of formula I ]R1 is an alkyl or OR5 (R5 is H or a protecti...
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JP2608322B2 |
(22E)-5,7,22-Ergostatriene-1 alpha ,3 beta ,25-triol and the 24-epimer thereof which are new intermediates for the synthesis of 1 alpha ,25-dihydroxyvitamin D2 and the 24-epimer thereof. A new process for the preparation of 1 alpha ,25-d...
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JPH09504549A |
The invention is drawn to 17-formyl vitamin D compounds having the following formula The compounds are intermediates in the production of 5,6-trans-(E)-20(22)-Dehydrovitamin D compounds which are useful for the treatment of diseases wher...
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JP2605123B2 |
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JP2602633B2 |
PURPOSE: To provide the subject compound, a vitamin D3 analog, which has activities to stimulate differentiation and to inhibit proliferation of human keratinocytes and is useful for the treatment and so on of hyperproliferative skin dis...
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JP2595036B2 |
Quaternary ammonium retinoate, characterized in that it corresponds to the formula: in which: X- denotes either an all-trans-retinoate of formula (I): or a 13-cis= retinoate of formula: (i) R1, R2 and R3, which may be identical or differ...
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JP2592204B2 |
PURPOSE: To provide an intraocular tension depressant little in side effect, excellent in therapeutic effect, useful for curing the intraocular tension rise concomitant with glaucoma or hypertension, containing, as active ingredient, a d...
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JP2590254B2 |
The invention relates to mixtures of compounds of the formula in which R represents C1-4-alkyl, in a ratio of at least 1.1:1, in particular 2.2-3.0:1. The invention also relates to the use of such mixtures as odoriferous substances.
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JP2579193B2 |
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